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ChemicalBook >> CAS DataBase List >>N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Structure
N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine structure
CAS No.
179552-74-0
Chemical Name:
N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine
Synonyms
Afatinib Impurity 137;Dacomitinib Intermediate 2;N-(3-chloro-2-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinamine;N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinam...;N - (3-Chloro-4-fluorophenyl) -7-methoxy-6-nitroquinoline-4-amine;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-;(3-chloro-4-fluoro-phenyl)-(7-methoxy-6-nitro-quinazolin-4-yl)-amine
CBNumber:
CB52629972
Molecular Formula:
C15H10ClFN4O3
Molecular Weight:
348.72
MDL Number:
MFCD27975589
MOL File:
179552-74-0.mol
Last updated:2025-09-22 14:50:28
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N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Properties

Boiling point 515.5±50.0 °C(Predicted)
Density 1.529±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 5.07±0.70(Predicted)

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C367560 N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine 179552-74-0 1g $160 2021-12-16 Buy
TRC C367560 N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine 179552-74-0 10g $1260 2021-12-16 Buy
AK Scientific 8006CZ N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine 179552-74-0 5g $331 2021-12-16 Buy
AK Scientific 8006CZ N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine 179552-74-0 10g $474 2021-12-16 Buy
Chemenu CM142805 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine 97% 179552-74-0 25g $542 2021-12-16 Buy
Product number Packaging Price Buy
C367560 1g $160 Buy
C367560 10g $1260 Buy
8006CZ 5g $331 Buy
8006CZ 10g $474 Buy
CM142805 25g $542 Buy

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Chemical Properties,Uses,Production

Uses

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine is a useful synthetic intermediate in the synthesis of Afatinib (A355300); an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

Synthesis

Methanol

67-56-1

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

162012-67-1

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine

179552-74-0

General procedure: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine (15 g, 44.56 mmol) was dissolved in methanol (150 mL) and 50% aqueous potassium hydroxide solution (5 g, 89 mmol) was added. The reaction mixture was stirred at room temperature and then heated to 70 °C and stirred continuously for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate. The organic layers were combined, washed with water and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to afford N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine (20 g, 96.7% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 10.16 (s, 1H), 9.21 (s, 1H), 8.67 (s, 1H), 8.15 (dd, J = 2.4,6.8 Hz, 1H), 7.79-7.81 (m, 1H), 7.48 (t, J = 7.2 Hz, 2H), 4.07 (s, 3H ).

References

[1] Patent: CN103987700, 2016, B. Location in patent: Paragraph 0182-0184
[2] Patent: US2014/161801, 2014, A1. Location in patent: Page/Page column 0079-0080
[3] Patent: WO2018/119441, 2018, A1. Location in patent: Paragraph 00618; 0619
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 7, p. 1495 - 1503
[5] Patent: CN106008480, 2016, A. Location in patent: Paragraph 0086; 0087; 0088; 0089

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Preparation Products And Raw materials

Raw materials

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine hydrochloride Sodium Methoxide Methanol 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

Preparation Products

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Suppliers

Global( 119)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 10997 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82375818 +86-15064153060 sales01@jndxj.com China 301 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Xiamen Shindano Biotechnology Co.,ltd 		0592-6266840 15750707980 sales@chemsdano.com China 291 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8826 58
Hebei Mujin Biotechnology Co.,Ltd 		+8613288715578 sales@hbmojin.com China 12248 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Anhui Dexinjia Biopharm Co., Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Xiamen Shindano Biotechnology Co.,ltd 		58
Antai Fine Chemical Technology Co.,Limited 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
Hebei Mujin Biotechnology Co.,Ltd 		58

View Lastest Price from N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dacomitinib Intermediate 2 pictures 2025-09-22 Dacomitinib Intermediate 2
179552-74-0
 US $41.00-93.00 / mg 99.27% 10g TargetMol Chemicals Inc.
N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine pictures 2025-08-08 N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine
179552-74-0
 US $100.00 / kg 1kg 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine pictures 2025-06-20 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
179552-74-0
 US $50.00 / KG 1KG 0.99 100000 Hebei Yanxi Chemical Co., Ltd.

179552-74-0(N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine)Related Search:

Afatinib iMpurity 4-Hydroxy 4-Dedimethylamino Afatinib Afatinib-d6 Afatinib IMpurity H Afatinib Impurity 74
Afatinib impurity 40 Afatinib impurity 33 TRANS-4-AMINOCROTONIC ACID Afatinib Impurity L (Afatinib N-Oxide) Afatinib Impurity 22
Afatinib impurity 30 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Afatinib impurity 27 Afatinib impurity 34 Afatinib impurity 41
Afatinib Impurity I Afatinib-d4 Afatinib Impurity K

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N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinamine (3-chloro-4-fluoro-phenyl)-(7-methoxy-6-nitro-quinazolin-4-yl)-amine 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro- Afatinib Impurity 137 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinam... N-(3-chloro-2-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine N - (3-Chloro-4-fluorophenyl) -7-methoxy-6-nitroquinoline-4-amine Dacomitinib Intermediate 2 179552-74-0 C15H10ClFN4O3