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5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde structure

CAS No.: 881674-56-2

Chemical Name:: 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

Synonyms: 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde;Vonorazan;VONOPRAZAN IST-1;5-(2-FL;e-3-carbaL;)-1H-pyrroL;Vonoprazan-1;Vonoprazan-023

CBNumber:: CB52638918

Molecular Formula:: C11H8FNO

Molecular Weight:: 189.19

MDL Number:: MFCD11875867

MOL File:: 881674-56-2.mol

MSDS File:: SDS

Last updated:2025-09-20 20:09:13

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5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Properties

Melting point	133 °C
Boiling point	370.6±32.0 °C(Predicted)
Density	1.270±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	14.77±0.50(Predicted)
color	Light Brown to Brown
Stability	Hygroscopic
InChI	InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H
InChIKey	MQULPEUCGKEHEG-UHFFFAOYSA-N
SMILES	N1C(C2=CC=CC=C2F)=CC(C=O)=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H302+H312+H332-H315
Precautionary statements	P280-P301+P312-P362+P364
HS Code	2933998090

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	F1074	5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde >98.0%(GC)	881674-56-2	1g	$98	2025-07-31	Buy
TCI Chemical	F1074	5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde >98.0%(GC)	881674-56-2	5g	$295	2025-07-31	Buy
TRC	F489655	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde	881674-56-2	1g	$105	2021-12-16	Buy
TRC	F489655	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde	881674-56-2	250mg	$50	2021-12-16	Buy
ChemScene	CS-W004473	5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde 99.96%	881674-56-2	10g	$67	2021-12-16	Buy

Product number	Packaging	Price	Buy
F1074	1g	$98	Buy
F1074	5g	$295	Buy
F489655	1g	$105	Buy
F489655	250mg	$50	Buy
CS-W004473	10g	$67	Buy

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties,Uses,Production

Description

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is an ether. It can be used to prepare vonoprazan fumarate, which is a potent orally active potassium-competitive acid blocker (P-CAB) with antisecretory activity. It is used in the study of acid-related diseases.

Chemical Properties

Light orange to Yellow to Green powder to crystal.

Uses

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).

Application

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.

Preparation

Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.

Definition

The 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde is an important intermediate of Voranolan fumarate, a competitive potassium ion acid blocker. Voranolan fumarate treats gastric ulcers, duodenal ulcers, reflux esophagitis, etc. 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde can be synthesized in one pot using 2-(2-fluorobenzoyl)malononitrile as raw material.

Hazard

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde has acute toxin effects and is a skin and eye irritant.

Synthesis

5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

1240948-77-9

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

881674-56-2

5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile (5.0 g, 26.9 mmol) was added to a four-necked flask with THF (33 mL) and stirred at 15-25 °C until completely dissolved. Subsequently, acetic acid (55 mL) and water (11 mL) were added sequentially. Under nitrogen protection, Raney nickel catalyst (Kawaken Fine Chemicals Co., Ltd., NDHT-90, 2.5 mL, wet weight 4 g) was added. The reaction mixture was stirred vigorously at 15-25 °C for about 3 h under hydrogen atmosphere. Upon completion of the reaction, the hydrogen was replaced with nitrogen, the Raney nickel was removed by filtration, and the catalyst was washed with ethyl acetate (50 mL). The filtrate was adjusted to pH 7 with 5N aqueous sodium hydroxide (~180 mL) at 10-35 °C. The organic layer was washed sequentially with 5% aqueous sodium bicarbonate (25 mL) and 5% brine (25 mL). Water (25 mL) was added to the organic layer and washed again with water. Subsequently, the pH was adjusted to 3.0-3.5 with 6N hydrochloric acid at 15-25 °C. After stirring overnight, the organic layer was separated and washed with 5% brine (25 mL). The organic layer was concentrated under reduced pressure, warmed to 65-70 °C and then cooled to 45-55 °C with continued stirring for 1 hour. Further cooled to 15 °C, n-heptane (25 mL) was added dropwise and stirred at the same temperature for 1 hour. Finally, the mixture was stirred at 0-10 °C for 1 h. The precipitated crystals were collected by filtration, washed with ethyl acetate:n-heptane (1:2, 15 mL), and dried under reduced pressure at 50 °C to constant weight to afford the target product 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde (23.9 g, 78% yield). The product was confirmed by 1H-NMR (300 MHz, DMSO-d6) and elemental analysis with melting point 123.0-126.0 °C.

References

[1] Patent: US2018/186736, 2018, A1. Location in patent: Paragraph 0139; 0140; 0141
[2] Patent: US2011/306769, 2011, A1. Location in patent: Page/Page column 28
[3] Patent: CN106432191, 2017, A. Location in patent: Paragraph 0019; 0022; 0023
[4] Patent: CN108558831, 2018, A. Location in patent: Paragraph 0161-0164

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde synthesis

Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde from 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)-

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials

Raw materials

2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)- 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-Pyrrole-3-carboxaldehyde, 5-broMo- 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester

2-Fluorophenylboronic acid 2-Fluorobenzoic acid Sodium hydroxide Hydrogen Hydrochloric acid

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Preparation Products

4-fluoro-5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Suppliers

Global( 520)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
AstaTech(Chengdu) Biopharmaceutical Corp.	+86-02882666559 +86-15884417729	gjpu@astatech.com.cn	China	308	58
Zhuhai Hairuide Bioscience and Technology Co., Ltd	+8618928027945	sales3@zhhairuide.com	China	97	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	+86-576-88902229;+86-0576-88902229 +8613968687450	yuxin@yuxchem.com	China	167	58
JUYE XIANDAI fine chemistry Co.,Ltd	+86-18958038633; +8618958038633	tony@sdhypharma.com	China	64	58
Hebei Mujin Biotechnology Co.,Ltd	+8613288715578	sales@hbmojin.com	China	12248	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1014	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	10997	58
Shandong Huisheng Import & Export Co., Ltd.	+86-13176845580	da@zhongda-biotech.com	China	232	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	286	58
Anhui Zhongda Biotechnology Co., Ltd	+8615689548120	linda@zhongda-biotech.com	China	193	58

Supplier	Advantage
AstaTech(Chengdu) Biopharmaceutical Corp.	58
Zhuhai Hairuide Bioscience and Technology Co., Ltd	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	58
JUYE XIANDAI fine chemistry Co.,Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Hangzhou ICH Biofarm Co., Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shandong Huisheng Import & Export Co., Ltd.	58
Anhui Zhongda Biotechnology Co., Ltd	58
Anhui Zhongda Biotechnology Co., Ltd	58

View Lastest Price from 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-05	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2	US $0.00-0.00 / kg	1kg	0.99	800kg	Wuhan Biocar Pharmacy CO.,Ltd.
2025-09-30	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2	US $0.00 / kg	1kg	98%	1000	Hebei Junhua Import and Export Co., LTD
2025-09-29	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2	US $0.00 / Kg/Bag	10g	99%min	10kg	WUHAN FORTUNA CHEMICAL CO., LTD

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
881674-56-2
US $0.00-0.00 / kg
0.99
Wuhan Biocar Pharmacy CO.,Ltd.

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
881674-56-2
US $0.00 / kg
98%
Hebei Junhua Import and Export Co., LTD

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
881674-56-2
US $0.00 / Kg/Bag
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

881674-56-2(5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde)Related Search:

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1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)- 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde 5-(2-Fluorophenyl)-1H-pyrrole-3-carbal... 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole- TAK438 Impurity 54 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde TAK-438( Vonoprazan fumarate) intermediate 3 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde 1-[(2S) -2-pyrrolidinecarbonyl] -pyrrolidine TAK438 Intermediate Vonoprazan-1 5-(2-Fluorophenyl)pyrrole-3-carbaldehyde Vonoprazan-023 5-(2-FL e-3-carbaL )-1H-pyrroL VONOPRAZAN IST-1 5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehy 5 - (2-fluorophenyl) - 1h-pyrrole-3-formaldehyde Vonorazan 5-(2-Fluorophenyl)-1H-pyrrol-3-carbaldehyde Vonolazan impurity 1 5-(2-fluorophenyl)-1H- 5- (2-Fluorophenyl) -1H-pyrrol-3-carboxaldehyde Novorazan Impurity 01 TAK438 Impurity 54 CRS 5-(2-Fluoropheny I)-1H-pyr role-3-carbaldehyde 5-(2-Fluorophenyl-IH-pyrole3-formaldehyde Vonoprazan intermediates 881674-56-2 881647-56-2 81674-56-2 Vonoprazan Pharmaceutical Intermediates 881674-56-2