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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline structure

CAS No.: 190728-25-7

Chemical Name:: 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

Synonyms: 6,7-Dimethoxy-4-(4-aminophenoxy)quinoline;Benzenam;PDGFR-IN-2;4-(6,7-Dimethoxy-quinoL;Cabozantinib Amine Analog;Intermediate 1 of Cabozantinib;Cabozantinib Genotoxic Impurity I;4-[(6,7-dimethoxy-4-quinolinyl)oxy]-;4-(6,7-dimethoxy quinolinoxy) aniline;4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline

CBNumber:: CB52652846

Molecular Formula:: C17H16N2O3

Molecular Weight:: 296.32

MDL Number:: MFCD19685633

MOL File:: 190728-25-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:17:42

Product description	Number	Pack Size	Price
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline	D5070	200mg	$112
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline	D5070	1g	$331
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline ≥98%(HPLC)	43936	200MG	$192.19
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline ≥98%(HPLC)	43936	1G	$638.36
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline 97%	D58928	250mg	$55.8
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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Properties

Melting point	211.0 to 215.0 °C
Boiling point	481.8±45.0 °C(Predicted)
Density	1.246±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly, Sonicated), Methanol (Slightly)
form	powder to crystal
pka	6.79±0.30(Predicted)
color	Light yellow to Brown
InChI	InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3
InChIKey	VXEQRXJATQUJSN-UHFFFAOYSA-N
SMILES	C1(N)=CC=C(OC2C3C(N=CC=2)=CC(OC)=C(OC)C=3)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

HS Code

2933.49.7000

NFPA 704

	0
2		0

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D5070	4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline	190728-25-7	200mg	$112	2026-04-30	Buy
TCI Chemical	D5070	4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline	190728-25-7	1g	$331	2026-04-30	Buy
Chem-Impex	43936	4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline ≥98%(HPLC)	190728-25-7	200MG	$192.19	2026-05-19	Buy
Chem-Impex	43936	4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline ≥98%(HPLC)	190728-25-7	1G	$638.36	2026-05-19	Buy
Synthonix	D58928	4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline 97%	190728-25-7	250mg	$55.8	2026-05-06	Buy

Product number	Packaging	Price	Buy
D5070	200mg	$112	Buy
D5070	1g	$331	Buy
43936	200MG	$192.19	Buy
43936	1G	$638.36	Buy
D58928	250mg	$55.8	Buy

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Chemical Properties,Uses,Production

Uses

4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity.

Chemical Reactivity

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline is a primary alcohol that has been shown to catalyze the reaction of potassium carbonate with an alkali metal hydroxide to produce potassium. It has also been shown to be a base catalyst for the reaction of cyclopropanecarboxylic acid with an alcohol ester to produce high yield.

Synthesis

Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)-

190728-24-6

190728-25-7

Step 2: Synthesis of 4-[(6,7-dimethoxyquinolin-4-yl)oxy]aniline (99) To a 1:1 MeOH/THF (50 mL) mixed solvent of 6,7-dimethoxy-4-(4-nitrophenoxy)quinoline (98) (0.25 g, 0.77 mmol) was added a solution of zinc powder (0.55 g, 8.4 mmol) and ammonium chloride (0.085 g, 1.6 mmol) in water (5 mL). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the insoluble material was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure. The concentrated residue was dissolved in dichloromethane, washed sequentially with water and saturated saline, and the organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product 99 (0.25 g, >100% yield), which can be used directly in the next reaction without further purification. Mass spectrometry (MS) data: m/z 297.1 ([M+H]+).

References

[1] Patent: US2008/4273, 2008, A1. Location in patent: Page/Page column 86
[2] Patent: CN108264482, 2018, A. Location in patent: Paragraph 0022; 0027
[3] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 23, p. 5117 - 5133
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 2018, vol. 61, # 1, p. 11 - 17
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6277 - 6292

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline synthesis

Synthesis of 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline from 4-chloro-6,7-dimethoxyquinoline and 4-Aminophenol

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Preparation Products And Raw materials

Raw materials

4-chloro-6,7-dimethoxyquinoline Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- 4-Aminophenol Water ZINC

Ammonium chloride Methanol Tetrahydrofuran

1of2

Preparation Products

Cabozantinib

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Suppliers

Global( 230)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Huanfu Industrial Co.，（Shanghai）Ltd.	+86-18001856580	2415195517@qq.com	China	43	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shandonghaohong biotechnology Co.,ltd.	0635-6175299 13961496334	sale@inyelchem.com	CHINA	44	55
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58

Supplier	Advantage
Huanfu Industrial Co.，（Shanghai）Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Shandonghaohong biotechnology Co.,ltd.	55
Anqing Chico Pharmaceutical Co., Ltd.	58
Lianyungang happen teng technology co., LTD	58

View Lastest Price from 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline 190728-25-7	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2024-11-26	4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline 190728-25-7		1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2023-03-12	BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]- 190728-25-7		1kg	98.0%min	100kg	LY Global chemicals co.,ltd .

4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
190728-25-7
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
190728-25-7
98%
Nanjing Fred Technology Co., Ltd

BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]-
190728-25-7
$0.00
98.0%min
LY Global chemicals co.,ltd .

190728-25-7(4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline)Related Search:

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Cabozantinib Malate

BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]- [4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]amine 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline BenzeMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]- 4-[(6,7-diMethoxy-4-quinolinyl)oxy]-BenzenaMine 4-(2,3-dimethoxynaphthalen-5-yloxy)benzenamine 4-[(6,7-dimethoxy-4-quinolinyl)oxy]- Intermediate 1 of Cabozantinib 6,7-Dimethoxy-4-(4-aminophenyloxy)quinolone 4-(6,7-dimethoxy quinolinoxy) aniline 4-[(6,7-dimethoxyquinolin-4-yl)oxy]aniline 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Cabozantinib Genotoxic Impurity I 4-(6,7-Dimethoxy-quinoL 4-(4-Aminophenoxy)-6,7-dimethoxyquinoline CAS 190728-25-7 BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]- 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline Cabozantinib Amine Analog Benzenam 1-((6,7-dimethoxyquinolin-4-yl)oxy)aniline 4-(6,7-dimethoxy quinoline-4-yloxy)phenylamine 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline? (Cabozantinib Impurity) 4-(6,7-dimethoxyquinolin-4-yl)oxyaniline, 10 mM in DMSO 190728-25-74-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline PDGFR-IN-2 Cabozantinib Impurity: 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline 6,7-Dimethoxy-4-(4-aminophenoxy)quinoline 190728-25-7 190827-25-7