Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile Structure
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile structure
CAS No.
68119-31-3
Chemical Name:
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
Synonyms
2,2-Difluoro-1,3-benzodioxole-5-acetonitrile;2-(2,2-difL;Lummakato impurities2;Thiocoraline Impurity15;2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl);(2,2-Difluorobenzodioxol-5-yl)acetonitrile;5-(Cyanomethyl)-2,2-Difluoro-1,3-benzodioxole;1,3-Benzodioxole-5-acetonitrile, 2,2-difluoro-;(2,2-Difluoro-1,3-benzodioxol-5-yl)acetonitrile;2,2-Difluorobenzo[d][1,3]dioxole-5-acetonitrile
CBNumber:
CB52658237
Molecular Formula:
C9H5F2NO2
Molecular Weight:
197.14
MDL Number:
MFCD09923942
MOL File:
68119-31-3.mol
MSDS File:
SDS
Last updated:2026-07-25 07:39:42
Product description Number Pack Size Price
2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile TRC-D452093-50MG 50mg $65
2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile TRC-D452093-500MG 500mg $96
2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile TRC-D452093-100MG 100mg $78
2,2-Difluoro-1,3-benzodioxole-5-acetonitrile 122383 1.00g $1073
2,2-Difluoro-1,3-benzodioxole-5-acetonitrile 97.0% D11709 1g $18
More product size
Request For Quotation

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile Properties

Boiling point 249.4±40.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Oil
color Pale Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-D452093-50MG 2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 68119-31-3 50mg $65 2026-06-03 Buy
TRC TRC-D452093-500MG 2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 68119-31-3 500mg $96 2026-06-03 Buy
TRC TRC-D452093-100MG 2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 68119-31-3 100mg $78 2026-06-03 Buy
Matrix Scientific 122383 2,2-Difluoro-1,3-benzodioxole-5-acetonitrile 68119-31-3 1.00g $1073 2026-05-18 Buy
Synthonix D11709 2,2-Difluoro-1,3-benzodioxole-5-acetonitrile 97.0% 68119-31-3 1g $18 2026-05-06 Buy
Product number Packaging Price Buy
TRC-D452093-50MG 50mg $65 Buy
TRC-D452093-500MG 500mg $96 Buy
TRC-D452093-100MG 100mg $78 Buy
122383 1.00g $1073 Buy
D11709 1g $18 Buy

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile Chemical Properties,Uses,Production

Synthesis

5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

476473-97-9

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile

68119-31-3

General procedure for the synthesis of (2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile from 5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxol-5-yl: To a solution of 5-(chloromethyl)-2,2-difluoro-1,3-benzo[d][1,3]dioxol-5-yl (1 eq.) in DMSO (1 vol.), NaCN (1.4 eq.) in a suspension in DMSO (3 vol), keeping the reaction temperature between 30-40 °C. The reaction mixture was stirred for 1 h and then water (6 vol) and methyl tert-butyl ether (MTBE, 4 vol) were added. The organic and aqueous layers were separated and the aqueous layer was further extracted with MTBE (1.8 vol). All organic layers were combined, washed with water (1.8 v/v) and subsequently dried over anhydrous sodium sulfate, filtered and concentrated to afford the crude product (2,2-difluoro-1,3-benzodioxol-5-yl)-acetonitrile in 95% yield. The crude product did not require further purification and could be used directly in the subsequent reaction step. The subsequent steps were the same as those described above for the acid portion of the synthesis.

References

[1] Patent: US2012/15999, 2012, A1
[2] Patent: WO2016/109362, 2016, A1. Location in patent: Paragraph 00160
[3] Patent: US2011/98311, 2011, A1

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile Preparation Products And Raw materials

Raw materials

sodium:cyanide 5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole 1335233-51-6 tert-Butyl methyl ether Sodium cyanide
Dimethyl sulfoxide

1of2

Preparation Products

1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile Suppliers

Global( 138)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20120 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2994 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hubei Ipure Biology Co., Ltd 		+8618062405514 ada@ipurechemical.com China 10236 58
ANHUI WITOP BIOTECH CO., LTD 		+8618071025641 eric@witopchemical.com China 23541 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52704 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Hubei Ipure Biology Co., Ltd 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile pictures 2026-07-24 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
68119-31-3
 1KG 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile pictures 2026-07-09 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
68119-31-3
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile pictures 2026-06-30 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
68119-31-3
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile Spectrum

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile(68119-31-3)1HNMR

68119-31-3(2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile)Related Search:

1-ETHYL-3-METHYLIMIDAZOLIUM DICYANAMIDE 2,2-Difluoro-1,3-benzodioxole-5-acetic acid 2-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-ethylamine 5-Ethyl-2,2-difluoro-1,3-benzodioxole (2,2-Difluoro-benzo[1,3]dioxol-4-yl)acetonitrile
1,3-Benzodioxole, 5-(2-chloroethyl)-2,2-difluoro-

1of2

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 1,3-Benzodioxole-5-acetonitrile, 2,2-difluoro- (2,2-Difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonitrile 2-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)acetonitrile 2-(2,2-difluoro-1,3-benzodioxol-5-yl)acetonitrile 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile (Related Reference) 2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl) (2,2-Difluoro-1,3-benzodioxol-5-yl)acetonitrile (2,2-Difluorobenzodioxol-5-yl)acetonitrile (2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 2-(2,2-difL 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile (Benzodiaxol carbonitrile) Lummakato impurities2 5-(Cyanomethyl)-2,2-Difluoro-1,3-benzodioxole 2,2-Difluorobenzo[d][1,3]dioxole-5-acetonitrile Thiocoraline Impurity15 2,2-Difluoro-1,3-benzodioxole-5-acetonitrile 68119-31-3