ChemicalBook >> CAS DataBase List >>2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine structure

CAS No.: 1260088-72-9

Chemical Name:: 2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine

Synonyms: 2,4-dichloro-7,7-dimethyl-5H-furo[3,4-d]pyrimidine;2,4-dichloro-7,7-dimethyl-5H,7H-furo[3,4-d]pyrimidine;2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine;2,4-dichloro-5,7-dihydro-7,7-dimethylFuro[3,4-d]pyrimidine;Furo[3,4-d]pyrimidine, 2,4-dichloro-5,7-dihydro-7,7-dimethyl-

CBNumber:: CB52658752

Molecular Formula:: C8H8Cl2N2O

Molecular Weight:: 219.07

MDL Number:: MFCD19688042

MOL File:: 1260088-72-9.mol

MSDS File:: SDS

Last updated:2026-05-28 04:35:00

Product description	Number	Pack Size	Price
2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine	KAC08872	250mg	$332.5
2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine	KAC08872	2.5g	$1504.5
2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine 98%	OR302091	50mg	$49
2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine 98%	OR302091	100mg	$60
2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine 98%	OR302091	250mg	$105
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2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine Properties

Boiling point	317.6±42.0 °C(Predicted)
Density	1.383±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-3.37±0.40(Predicted)
Appearance	Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HS Code	2933599590

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	KAC08872	2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine	1260088-72-9	250mg	$332.5	2026-06-04	Buy
Biosynth	KAC08872	2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine	1260088-72-9	2.5g	$1504.5	2026-06-04	Buy
Apolloscientific	OR302091	2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine 98%	1260088-72-9	50mg	$49	2026-06-04	Buy
Apolloscientific	OR302091	2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine 98%	1260088-72-9	100mg	$60	2026-06-04	Buy
Apolloscientific	OR302091	2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine 98%	1260088-72-9	250mg	$105	2026-06-04	Buy

Product number	Packaging	Price	Buy
KAC08872	250mg	$332.5	Buy
KAC08872	2.5g	$1504.5	Buy
OR302091	50mg	$49	Buy
OR302091	100mg	$60	Buy
OR302091	250mg	$105	Buy

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine Chemical Properties,Uses,Production

Uses

2,4-Dichloro-5,7-dihydro-7,7-dimethylfuro[3,4-d]pyrimidine is used for preparation and study of pharmacokinetics, and antitumor activity of dihydrofuro[3,4-d]pyrimidines as inhibitors of mammalian target of rapamycin kinase.

Synthesis

7,7-DiMethyl-1H,2H,3H,4H,5H,7H-furo[3,4-d]pyriMidine-2,4-dione

1260088-71-8

1260088-72-9

Step 3 - Synthesis of 2,4-dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine (p): a mixture of 7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine-2,4(1H,3H)-dione (o) (2.55 g, 14.0 mmol), phosphinic acid chloride (15 mL, 160 mmol) and 1,2-dichloroethane ( The mixture of 80 mL) was heated at 80 °C for 20 hours. Upon completion of the reaction, the mixture was concentrated to a solid and partitioned between dichloromethane (250 mL) and saturated NaHCO3 solution (500 mL). The organic and aqueous phases were separated and the aqueous phase was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, dried over anhydrous Na2SO4, filtered and concentrated to afford 2.53 g (82% yield) of 2,4-dichloro-7,7-dimethyl-5,7-dihydrofurano[3,4-d]pyrimidine (p) as a colorless solid. Product characterization data: 1H NMR (400 MHz, CDCl3) δ 5.02 (s, 2H), 1.51 (s, 6H); LC-MS: m/z = 219(M+H)+.

References

[1] Patent: US2010/331305, 2010, A1. Location in patent: Page/Page column 32-33
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 9, p. 3426 - 3435

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine Preparation Products And Raw materials

Raw materials

7,7-DiMethyl-1H,2H,3H,4H,5H,7H-furo[3,4-d]pyriMidine-2,4-dione 1,2-Dichloroethane Sodium bicarbonate trichlorophosphate Dichloromethane

Preparation Products

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine Suppliers

Global( 52)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.	+86-029-86185165 +8618629664246	guoyuan@eastchinapharm.com	China	1615	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	sales@bicbiotech.com	China	5994	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hefei Hirisun Pharmatech Co., Ltd	58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Nanjing Bicbiotechnology Co., Ltd	58
Aladdin Scientific	58

View Lastest Price from 2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-10	2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine 1260088-72-9	$1.00	1g	97%	100kg	Career Henan Chemical Co

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine
1260088-72-9
$1.00
97%
Career Henan Chemical Co

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine Spectrum

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine(1260088-72-9)¹HNMR

2,4-dichloro-5,7-dihydro-7,7-dimethylFuro[3,4-d]pyrimidine 2,4-dichloro-7,7-dimethyl-5H-furo[3,4-d]pyrimidine 2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine 2,4-dichloro-7,7-dimethyl-5H,7H-furo[3,4-d]pyrimidine Furo[3,4-d]pyrimidine, 2,4-dichloro-5,7-dihydro-7,7-dimethyl- 1260088-72-9