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ChemicalBook >> CAS DataBase List >>4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester Structure
4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester structure
CAS No.
1053656-57-7
Chemical Name:
4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester
Synonyms
tert-Butyl 4-chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H);tert-Butyl 4-chloro-5H,6H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate;Tert-butyl 4-chloro-6,8-dihydro-5h-pyrido[3,4-d]pyrimidine-7-carboxylat;tert-butyl 4-chloro-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxylate;4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester;Pyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid, 4-chloro-5,8-dihydro-, 1,1-dimethylethyl ester
CBNumber:
CB52663866
Molecular Formula:
C12H16ClN3O2
Molecular Weight:
269.73
MDL Number:
MFCD11109465
MOL File:
1053656-57-7.mol
Last updated:2025-10-14 17:28:51
Product description Number Pack Size Price
tert-Butyl4-Chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8h)-carboxylate B811120 10mg $45
tert-Butyl 4-chloro-5H,6H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate 4H51-5-04 250mg $265
tert-Butyl 4-chloro-5,6-dihydropyrido-[3,4-d]pyrimidine-7(8H)-carboxylate 95+% 073178 250mg $370
tert-Butyl4-chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate X8758 1g $518
tert-Butyl 4-chloro-5H,6H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate 4H51-5-04 1g $825
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4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester Properties

Boiling point 395.8±42.0 °C(Predicted)
Density 1.266±0.06 g/cm3(Predicted)
storage temp. -20°C, sealed storage, away from moisture
pka -0.04±0.20(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C12H16ClN3O2/c1-12(2,3)18-11(17)16-5-4-8-9(6-16)14-7-15-10(8)13/h7H,4-6H2,1-3H3
InChIKey XYHXUYOSXZHUSZ-UHFFFAOYSA-N
SMILES C1=NC(Cl)=C2CCN(C(OC(C)(C)C)=O)CC2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B811120 tert-Butyl4-Chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8h)-carboxylate 1053656-57-7 10mg $45 2021-12-16 Buy
SynQuest Laboratories 4H51-5-04 tert-Butyl 4-chloro-5H,6H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate 1053656-57-7 250mg $265 2021-12-16 Buy
Matrix Scientific 073178 tert-Butyl 4-chloro-5,6-dihydropyrido-[3,4-d]pyrimidine-7(8H)-carboxylate 95+% 1053656-57-7 250mg $370 2021-12-16 Buy
AK Scientific X8758 tert-Butyl4-chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate 1053656-57-7 1g $518 2021-12-16 Buy
SynQuest Laboratories 4H51-5-04 tert-Butyl 4-chloro-5H,6H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate 1053656-57-7 1g $825 2021-12-16 Buy
Product number Packaging Price Buy
B811120 10mg $45 Buy
4H51-5-04 250mg $265 Buy
073178 250mg $370 Buy
X8758 1g $518 Buy
4H51-5-04 1g $825 Buy

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production

Synthesis

tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate

1142188-60-0

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester

1053656-57-7

General procedure for the synthesis of tert-butyl 4-chloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate from tert-butyl 4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate: to a solution of intermediate 1 (1.26 g, 5.02 mmol) in ethylene dichloride (DCE, 36 mL), sequentially added triphenylphosphine (PPh3, 2.69 g, 10.05 mmol) and carbon tetrachloride (CCl4, 1.46 mL, 15.07 mmol). The reaction mixture was heated to 70 °C and maintained for 2.5 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and purified by silica gel (SiO2) column chromatography with ethyl acetate/hexane as eluent to afford the target compound as a light yellow solid (1.20 g, 88% yield). The mass spectrometry (ESI) calculated value of C12H16ClN3O2 was 269.09, and the measured value m/z 270.1 [M + H]+.1H NMR (400 MHz, CDCl3) δ: 8.79 (s, 1H), 4.65 (br s, 2H), 3.80-3.68 (m, 2H), 2.93-2.82 (m, 2H), 1.49 ( s, 9H).

References

[1] Patent: US2014/275120, 2014, A1. Location in patent: Paragraph 0160; 0161
[2] Patent: WO2011/29842, 2011, A1. Location in patent: Page/Page column 40-41
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 2, p. 186 - 190
[4] Patent: US2016/75708, 2016, A1. Location in patent: Paragraph 0086; 0092
[5] Patent: KR2015/139962, 2015, A. Location in patent: Paragraph 0118-0119; 0131-0132

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

tert-butyl 4-oxo-3,4,5,6-tetrahydropyrido[3,4-d]pyriMidine-7(8H)-carboxylate 1,2-Dichloroethane Carbon tetrachloride Triphenylphosphine

Preparation Products

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester Suppliers

Global( 79)Suppliers
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Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
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Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29794 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Blocksynth Pharmaceutical Technology Co.,Ltd 		0086-19817745290; +8619817745290 bd@blocksynth.com China 5973 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9080 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43333 58
Nanjing Bicbiotechnology Co., Ltd 		+86-2552131256 +86-18251840740 sales@bicbiotech.com China 5994 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Blocksynth Pharmaceutical Technology Co.,Ltd 		58
Baoji Guokang Healthchem Co., Ltd. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Nanjing Bicbiotechnology Co., Ltd 		58
Aladdin Scientific 		58

View Lastest Price from 4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester pictures 2021-07-13 4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester
1053656-57-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester pictures 2021-07-10 4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester
1053656-57-7
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
tert-Butyl 4-chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate pictures 2020-02-09 tert-Butyl 4-chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
1053656-57-7
 US $1.00 / GK 1g Min98% HPLC g/kg/ton Career Henan Chemical Co

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester Spectrum

4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester(1053656-57-7)1HNMR

1053656-57-7(4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester)Related Search:

TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyriMidine-7-carboxylic acid tert-butyl ester tert-Butyl 4-chloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H) tert-butyl 4-chloro-6,8-dihydro-5H-pyrido[3,4-d]pyrimidine-7-carboxylate tert-Butyl 4-chloro-5H,6H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate Pyrido[3,4-d]pyrimidine-7(6H)-carboxylic acid, 4-chloro-5,8-dihydro-, 1,1-dimethylethyl ester Tert-butyl 4-chloro-6,8-dihydro-5h-pyrido[3,4-d]pyrimidine-7-carboxylat 1053656-57-7