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TAK-593

TAK-593 Structure
TAK-593 structure
CAS No.
1005780-62-0
Chemical Name:
TAK-593
Synonyms
TAK-593;TAK-593, 10 mM in DMSO;N-(5-((2-(Cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl)oxy)-2-methylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide;1H-Pyrazole-5-carboxamide, N-[5-[[2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl]oxy]-2-methylphenyl]-1,3-dimethyl-;Platelet-derived growth factor receptor,VEGFR,PDGFR,Inhibitor,TAK 593,inhibit,TAK593,TAK-593,Vascular endothelial growth factor receptor
CBNumber:
CB52667086
Molecular Formula:
C23H23N7O3
Molecular Weight:
445.47
MDL Number:
MFCD23160045
MOL File:
1005780-62-0.mol
Last updated:2025-11-11 10:47:11
Product description Number Pack Size Price
TAK-593 99.62% CS-2403 5mg $180
TAK-593 99.62% CS-2403 10mg $300
TAK-593 99.62% CS-2403 50mg $936
TAK-593 99.62% CS-2403 100mg $1440
TAK-593 98+% CD31004878 50mg $840
Request For Quotation

TAK-593 Properties

Density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 9.22±0.20(Predicted)
form Solid
color White to light yellow
InChIKey DZFZXPPHBWCXPQ-UHFFFAOYSA-N
SMILES N1(C)C(C(NC2=CC(OC3=NN4C=C(NC(C5CC5)=O)N=C4C=C3)=CC=C2C)=O)=CC(C)=N1
FDA UNII H3I42X8XX7

TAK-593 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-2403 TAK-593 99.62% 1005780-62-0 5mg $180 2021-12-16 Buy
ChemScene CS-2403 TAK-593 99.62% 1005780-62-0 10mg $300 2021-12-16 Buy
ChemScene CS-2403 TAK-593 99.62% 1005780-62-0 50mg $936 2021-12-16 Buy
ChemScene CS-2403 TAK-593 99.62% 1005780-62-0 100mg $1440 2021-12-16 Buy
Crysdot CD31004878 TAK-593 98+% 1005780-62-0 50mg $840 2021-12-16 Buy
Product number Packaging Price Buy
CS-2403 5mg $180 Buy
CS-2403 10mg $300 Buy
CS-2403 50mg $936 Buy
CS-2403 100mg $1440 Buy
CD31004878 50mg $840 Buy

TAK-593 Chemical Properties,Uses,Production

Uses

TAK-593 is a potent VEGFR and PDGFR family inhibitor with IC50s of 3.2, 0.95, 1.1, 4.3 and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα and PDFGRβ, respectively.

in vivo

TAK-593 inhibits growth of HUVEC with an IC50 of 0.30 nM. It shows potent inhibitory activity against VEGFR (VEGFR1-3: IC50=3.2, 0.95, 1.1 nM) and PDGFR (PDGFRα, β: IC50=4.3, 13 nM) families. Against other kinases, the IC50 values of TAK-593 are above 100 nM, except for Fms (IC50=10 nM) and Ret (IC50=18 nM) kinases[1]. TAK-593 potently inhibits VEGF- and PDGF-stimulated cellular phosphorylation and proliferation of human umbilical vein endothelial cells and human coronary artery smooth muscle cells. TAK-593 also potently inhibits VEGF-induced tube formation of endothelial cells co-cultured with fibroblasts[2].

IC 50

VEGFR1: 3.2 nM (IC50); VEGFR2: 0.95 nM (IC50); VEGFR3: 1.1 nM (IC50); PDGFRα: 4.3 nM (IC50); PDGFRβ: 13 nM (IC50); PDGFRαV561D: 1 nM (IC50)

References

[1] Miyamoto N, et al. Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor. Bioorg Med Chem. 2013 Apr 15;21(8):2333-2345. DOI:10.1016/j.bmc.2013.01.074
[2] Awazu Y, et al. Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase. Cancer Sci. 2013 Apr;104(4):486-94. DOI:10.1111/cas.12101

TAK-593 Preparation Products And Raw materials

Raw materials

Preparation Products

TAK-593 Suppliers

Global( 44)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 1014988033@qq.com China 4941 55
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2989 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
SPIRO PHARMA eric_feng1954@126.com China 9248 55
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3866 58
Musechem +1-800-259-7612 info@musechem.com United States 4660 60
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 3934 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
MQ (shanghai) Pharmaceuticals Co., Ltd. 55
Shanghai Rechem science Co., Ltd. 58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
SPIRO PHARMA 55
Guangzhou QiYun Biotechnology Co., Ltd. 58
Musechem 60
Changzhou Chenhong Biotechnology Co., Ltd. 58

View Lastest Price from TAK-593 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TAK-593 pictures 2025-11-10 TAK-593
1005780-62-0
 US $59.00-203.00 / mg 99.18% 10g TargetMol Chemicals Inc.
  • TAK-593 pictures
  • TAK-593
    1005780-62-0
  • US $59.00-203.00 / mg
  • 99.18%
  • TargetMol Chemicals Inc.

TAK-593 Spectrum

TAK-593(1005780-62-0)1HNMR
TAK-593 1H-Pyrazole-5-carboxamide, N-[5-[[2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl]oxy]-2-methylphenyl]-1,3-dimethyl- Platelet-derived growth factor receptor,VEGFR,PDGFR,Inhibitor,TAK 593,inhibit,TAK593,TAK-593,Vascular endothelial growth factor receptor N-(5-((2-(Cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl)oxy)-2-methylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide TAK-593, 10 mM in DMSO 1005780-62-0