ChemicalBook >> CAS DataBase List >>Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- structure

CAS No.: 1231930-25-8

Chemical Name:: Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-

Synonyms: Abemaciclib Impurity 5;1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-;1-[(6-Bromo-3-pyridyl)methyl]-4-ethylpiperazine;1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine;1-[(6-bromo-3-pyridinyl)methyl]-4-ethylPiperazine;Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-

CBNumber:: CB52668043

Molecular Formula:: C12H18BrN3

Molecular Weight:: 284.2

MDL Number:: MFCD25977325

MOL File:: 1231930-25-8.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:44

Product description	Number	Pack Size	Price
1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine	B678523	500mg	$175
1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine	3276AQ	1g	$220.4
1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine 95%	171771	5g	$1733
1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine 97%	CM170052	1g	$102
1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine 97%	CM170052	5g	$281
More product size

Request For Quotation

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Properties

Boiling point	365.4±37.0 °C(Predicted)
Density	1.328±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	7.67±0.10(Predicted)
Appearance	Off-white to light yellow Solid
InChI	InChI=1S/C12H18BrN3/c1-2-15-5-7-16(8-6-15)10-11-3-4-12(13)14-9-11/h3-4,9H,2,5-8,10H2,1H3
InChIKey	DMNPLEDMMNWHTL-UHFFFAOYSA-N
SMILES	N1(CC2=CC=C(Br)N=C2)CCN(CC)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B678523	1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine	1231930-25-8	500mg	$175	2021-12-16	Buy
AK Scientific	3276AQ	1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine	1231930-25-8	1g	$220.4	2021-12-16	Buy
Matrix Scientific	171771	1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine 95%	1231930-25-8	5g	$1733	2021-12-16	Buy
Chemenu	CM170052	1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine 97%	1231930-25-8	1g	$102	2021-12-16	Buy
Chemenu	CM170052	1-((6-Bromopyridin-3-yl)methyl)-4-ethylpiperazine 97%	1231930-25-8	5g	$281	2021-12-16	Buy

Product number	Packaging	Price	Buy
B678523	500mg	$175	Buy
3276AQ	1g	$220.4	Buy
171771	5g	$1733	Buy
CM170052	1g	$102	Buy
CM170052	5g	$281	Buy

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Chemical Properties,Uses,Production

Synthesis

5308-25-8

149806-06-4

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-

1231930-25-8

To 100 mL of anhydrous dichloromethane (DCM) were added N-ethylpiperazine (10 g, 54 mmol) and 2-bromo-5-formylpyridine (6.20 g, 54.00 mmol) followed by batchwise addition of sodium triacetoxyborohydride (NaHB(OAc)3, 17.20 g, 81.00 mmol). The reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the mixture was diluted with DCM (100 mL) and the pH was adjusted to 8-10 by adding saturated sodium carbonate (Na2CO3) solution. the mixture was partitioned between water and dichloromethane. The aqueous phase was extracted twice with dichloromethane. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated in vacuum. The crude product was purified by silica gel column chromatography (eluent: DCM/MeOH = 50:1) to afford the target compound 1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine (8a, 14.00 g, 92.00% yield) as a yellow solid. Mass spectrum (ESI): calculated value C12H18BrN3 [M+H]+ 284, measured value 284.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 5, p. 974 - 978
[2] Patent: CN105622638, 2016, A. Location in patent: Paragraph 0220
[3] Patent: CN106608879, 2017, A. Location in patent: Paragraph 0142-0145
[4] European Journal of Medicinal Chemistry, 2018, vol. 144, p. 1 - 28
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1892 - 1915

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Preparation Products And Raw materials

Raw materials

1-Ethylpiperazine 2-Bromopyridine-5-carbaldehyde Dichloromethane Sodium triacetoxyborohydride

Preparation Products

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Suppliers

Global( 76)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Moxin Chemicals	+86-17320513646 +8617320513646	anna@molcoo.com	China	10000	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Hangzhou Proserre Chemical Co.,Ltd.	+86-571-86088112	info@proserre.com	China	1077	58

Supplier	Advantage
Accela ChemBio Inc.	58
Moxin Chemicals	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
Labnetwork lnc.	58
Hangzhou Proserre Chemical Co.,Ltd.	58

View Lastest Price from Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-07-31	Abemaciclib Impurity 39 1231930-25-8	US $0.00-0.00 / mg	10mg	95%+	10000	Moxin Chemicals
	2020-01-09	Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- 1231930-25-8	US $6.68 / KG	1KG	97%-99%	1kg-1000kg	Career Henan Chemical Co

Abemaciclib Impurity 39
1231930-25-8
US $0.00-0.00 / mg
95%+
Moxin Chemicals

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-
1231930-25-8
US $6.68 / KG
97%-99%
Career Henan Chemical Co

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Spectrum

Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-(1231930-25-8)¹HNMR

1231930-25-8(Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl-)Related Search:

Savolitinib 1-((2-(dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)methyl)-4-methylpiperazin-2-one 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione O-(2-(vinyloxy)ethyl)hydroxylamine

1-[(6-bromo-3-pyridinyl)methyl]-4-ethylPiperazine 1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- Piperazine, 1-[(6-broMo-3-pyridinyl)Methyl]-4-ethyl- 1-[(6-Bromo-3-pyridyl)methyl]-4-ethylpiperazine Abemaciclib Impurity 5 1231930-25-8