ChemicalBook >> CAS DataBase List >>(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride structure

CAS No.: 1185503-48-3

Chemical Name:: (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride

Synonyms: Aprepitant intermediate 1;Fosaprepitant Impurity 31;Aprepitant Impurity 12 HCl;Aprepitant intermediate 1 HCl;Arepitam intermediate 1 hydrochloride;Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant;(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophe;Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-;(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride

CBNumber:: CB52669000

Molecular Formula:: C20H18F7NO2

Molecular Weight:: 437.35

MDL Number:

MOL File:: 1185503-48-3.mol

Product description	Number	Pack Size	Price
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant	446146	1mg	$368
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant	446146	5mg	$638
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant	AA01DZTV	1mg	$560
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant	AA01DZTV	5mg	$898
Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1''R)-Aprepitant	D297835	1mg	$90

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(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Properties

Boiling point	387.9±42.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
pka	6.93±0.60(Predicted)

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	446146	Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant	1185503-48-3	1mg	$368	2026-06-03	Buy
Usbiological	446146	Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant	1185503-48-3	5mg	$638	2026-06-03	Buy
aablocks	AA01DZTV	Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant	1185503-48-3	1mg	$560	2026-05-30	Buy
aablocks	AA01DZTV	Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant	1185503-48-3	5mg	$898	2026-05-30	Buy
TRC	D297835	Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1''R)-Aprepitant	1185503-48-3	1mg	$90	2021-12-16	Buy

Product number	Packaging	Price	Buy
446146	1mg	$368	Buy
446146	5mg	$638	Buy
AA01DZTV	1mg	$560	Buy
AA01DZTV	5mg	$898	Buy
D297835	1mg	$90	Buy

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Chemical Properties,Uses,Production

Uses

Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1''R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Suppliers

Global( 38)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Moxin Chemicals	+86-17320513646 +8617320513646	anna@molcoo.com	China	10000	58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd.	+undefined18603013401	jack.lin@sincopharmachem.com	China	9996	58
QUALITY CONTROL SOLUTIONS LTD.	+86-0755-66853366 +8613670046396	export03@qcsrm.com	China	24342	58
Shanghai Ranxon Chemical Co., Ltd.	13148101715	2073632910@qq.com	China	38	55
Nanjing XiZe Biotechnology CO., Ltd.	025-66023220 15250997978	1511893459@qq.com	China	4849	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Shenzhen SUNGENING Bio-Medical Co., Ltd.	0755-28967200 13631290199	wxf@sungening.com	China	9629	60

Supplier	Advantage
ANHUI WITOP BIOTECH CO., LTD	58
BOC Sciences	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Moxin Chemicals	58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd.	58
QUALITY CONTROL SOLUTIONS LTD.	58
Shanghai Ranxon Chemical Co., Ltd.	55
Nanjing XiZe Biotechnology CO., Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shenzhen SUNGENING Bio-Medical Co., Ltd.	60

1185503-48-3((2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride)Related Search:

Aprepitant Impurity 17 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine Aprepitant Aprepitant

Fosaprepitant Impurity 6 [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Aprepitant

Fosaprepitant Impurity 5 5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one (S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one 1,1,1-Trimethoxy-2-chloroethane Aprepitant

(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine

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(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Aprepitant Impurity 12 HCl Fosaprepitant Impurity 31 Arepitam intermediate 1 hydrochloride Aprepitant intermediate 1 Aprepitant intermediate 1 HCl Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)- Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophe 1185503-48-3