Helioxanthin derivative 5-4-2
- CAS No.
- 203935-39-1
- Chemical Name:
- Helioxanthin derivative 5-4-2
- Synonyms
- CS-1214;Helioxanthin 5-4-2;Helioxanthin derivative 5-4-2;Helioxanthin derivative 542,Helioxanthin derivative 5 4 2;7H-1,3-Dioxolo[3,4]benz[1,2-f]isoindol-7-one, 10-(1,3-benzodioxol-5-yl)-8,9-dihydro-
- CBNumber:
- CB52715637
- Molecular Formula:
- C20H13NO5
- Molecular Weight:
- 347.32
- MDL Number:
- MFCD28167791
- MOL File:
- 203935-39-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Helioxanthin derivative 5-4-2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3197 | Helioxanthin derivative 5-4-2 99.80% | 203935-39-1 | 1mg | $260 | 2026-06-04 | Buy |
| ChemScene | CS-3197 | Helioxanthin derivative 5-4-2 99.80% | 203935-39-1 | 5mg | $780 | 2026-06-04 | Buy |
| ApexBio Technology | B4700 | Helioxanthin derivative 5-4-2 | 203935-39-1 | 2mg | $363 | 2026-05-06 | Buy |
| ApexBio Technology | B4700 | Helioxanthin derivative 5-4-2 | 203935-39-1 | 5mg | $545 | 2026-05-06 | Buy |
| ApexBio Technology | B4700 | Helioxanthin derivative 5-4-2 | 203935-39-1 | 10mg | $779 | 2026-05-06 | Buy |
Helioxanthin derivative 5-4-2 Chemical Properties, Uses, Production
Uses
Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells. IC50 value: 0.08 uM (EC50) [1][2] Target: Anti-HBV Helioxanthin derivative 5-4-2 had potent anti-HBV activities in HepG2.2.15 cells, with the EC50s of 1 and 0.08 microM, respectively. The lamivudine-resistant HBV, L526M/M550V double mutant strain, was also sensitive to helioxanthin and 5-4-2. This class of compounds not only inhibited HBV DNA, but also decreased HBV mRNA and HBV protein expression. The EC50 of HBV DNA inhibition was consistent with the EC50 of HBV 3.5 Kb transcript inhibition, which was 1 and 0.09 microM for helioxanthin and 5-4-2 respectively.
Biological Activity
helioxanthin derivative 5-4-2, an analogue of helioxanthin (ach126447), is a small-molecule inhibitor of hbv, hsv-1and hsv-2 virus with ec50 values of 0.08 μm, 0.29 μm and 0.16 μm, respectively [1].helioxanthin derivative 5-4-2 is a lactam and has been reported to inhibit the hbv dna and rna and viral protein expression [2]. helioxanthin derivative 5-4-2 has significant anti-virus activity with ec50 values of 0.08 μm, 0.29 μm and 0.16 μm for hbv(hepatitis b virus), hsv-1(herpes simplex virus type 1) and hsv-2(herpes simplex virus type 2), respectively [1]. in addition, helioxanthin derivative 5-4-2 inhibited hbv replication by post-transcriptional down-regulation of necessary transcription factors [3]. helioxanthin derivative 5-4-2 has also exhibited potent anti-hcv (hepatitis c virus) activity with 55% inhibition at 1.0 μm and 80%inhibition at 3.0 μm [1].
References
[1] yeo h1, li y, fu l, zhu jl, gullen ea, dutschman ge, lee y, chung r, huang es, austin dj, cheng yc. synthesis and antiviral activity of helioxanthin analogues. j med chem. 2005 jan 27;48(2):534-46.
[2] li y1, fu l, yeo h, zhu jl, chou ck, kou yh, yeh sf, gullen e, austin d, chengyc.inhibition of hepatitis b virus gene expression and replication by helioxanthin and its derivative. antivir chem chemother. 2005;16(3):193-201.
[3] stein ll1, loomba r. drug targets in hepatitis b virus infection. infect disord drug targets. 2009 apr;9(2):105-16.
Helioxanthin derivative 5-4-2 Preparation Products And Raw materials
Raw materials
Preparation Products
Helioxanthin derivative 5-4-2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2728 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| MedChemexpress LLC | 58 |
| SPIRO PHARMA | 55 |
| BOC Sciences | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 58 |
| Musechem | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Cckinase, Inc. | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
