Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>AZD-5582

AZD-5582

AZD-5582 Structure
AZD-5582 structure
CAS No.
1258392-53-8
Chemical Name:
AZD-5582
Synonyms
ZD5582;CS-2673;AZD-5582;AZD5582 ，S7362;AZD5582;AZD-5582;AZD 5582;3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide];L-Prolinamide, 3,3'-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-;(2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide);(2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide);(S,S,2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)
CBNumber:
CB52731019
Molecular Formula:
C58H78N8O8
Molecular Weight:
1015.29
MDL Number:
MFCD28411397
MOL File:
1258392-53-8.mol
Last updated:2025-09-30 18:11:34
Request For Quotation

AZD-5582 Properties

Boiling point 1207.3±65.0 °C(Predicted)
Density 1.26±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light, stored under nitrogen
solubility DMF: 30 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml
form A crystalline solid
pka 12.99±0.40(Predicted)
color White to yellow
InChIKey BRCXWBBDZROUEZ-WCMFYDHYSA-N
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

AZD-5582 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2900 AZD5582 ≥98% (HPLC) 1258392-53-8 5mg $121 2025-07-31 Buy
Sigma-Aldrich SML2900 AZD5582 ≥98% (HPLC) 1258392-53-8 25mg $489 2025-07-31 Buy
TRC A808300 AZD5582 1258392-53-8 1mg $165 2021-12-16 Buy
Activate Scientific AS117573 AZD5582 98+% 1258392-53-8 5mg $177 2021-12-16 Buy
Activate Scientific AS117573 AZD5582 98+% 1258392-53-8 1mg $88 2021-12-16 Buy
Product number Packaging Price Buy
SML2900 5mg $121 Buy
SML2900 25mg $489 Buy
A808300 1mg $165 Buy
AS117573 5mg $177 Buy
AS117573 1mg $88 Buy

AZD-5582 Chemical Properties,Uses,Production

Uses

It is a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer.

Biological Activity

AZD5582 is a divalent AVPI motif-based Smac (DIABLO) mimetic (SMC) th at acts a potent apoptosis protein repe at (BIR) domain-targeting antagonist against inhibitor of apoptosis proteins (IAPs) cIAP1/2 (BIR3 IC50 = 15/21 nM against 2.5 nM AbuRPFK-5FAM) and XIAP (BIR2/3 IC50 = 21/15 nM). AZD5582 abolishes cellular XIAP-caspase-9 interaction (1 μM, 4 hrs), induces cIAP1/2 degradation (EC50 = 0.1 nM, 1 hr) and apoptosis (GI50 <60 pM, 48 hrs) in MDA-MB-231 breast cancer cultures. AZD5582 causes substantial tumor regression by inducing cIAP1 degradation and apoptosis in tumor cells in MDA-MB-231 xenograft-bearing mice in vivo (3.0 mg/kg/wk i.v.).

in vivo

AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) causes degradation of cIAP1 and caspase 3 cleavage in tumor cells, and after a two-week treatment, the tumors largely resolved; when the mice are given a medium dose (0.5 mg/kg) of AZD5582, cIAP1 degrades after administration, but it takes a while time to reach apoptosis-inducing effect[1].

Animal Model:MDA-MB-231 xenograft-bearing mice[1]
Dosage:0.1 mg/kg, 0.5 mg/kg, 3.0 mg/kg
Administration:Intravenous injection; once a week; 2 weeks
Result:Resulted in cIAP1 degradation and caspase-3 cleavage within tumor cells and causes substantial tumor regressions following two weekly doses of 3.0 mg/kg

IC 50

cIAP1: 15 nM (IC50); cIAP2: 21 nM (IC50); XIAP: 15 nM (IC50)

AZD-5582 Preparation Products And Raw materials

Raw materials

Preparation Products

AZD-5582 Suppliers

Global( 98)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32433 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39031 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from AZD-5582 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AZD5582 pictures 2025-09-30 AZD5582
1258392-53-8
 US $49.00 / mg 98.75% 10g TargetMol Chemicals Inc.
AZD5582 pictures 2025-09-30 AZD5582
1258392-53-8
 US $49.00 / mg 98.75% 10g TargetMol Chemicals Inc.
  • AZD5582 pictures
  • AZD5582
    1258392-53-8
  • US $49.00 / mg
  • 98.75%
  • TargetMol Chemicals Inc.
  • AZD5582 pictures
  • AZD5582
    1258392-53-8
  • US $49.00 / mg
  • 98.75%
  • TargetMol Chemicals Inc.

1258392-53-8(AZD-5582)Related Search:

(R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate hydrochloride salt Angiontensin(1-7) AZD-4547 AZD5153 AZD 7762 hydrochloride
1626387-81-2 AZD2098 AZD5153 AZD-7594 1802148-05-5
AZD8186 ALK/IGF1R inhibitor AZD-0156 azd4635 AZD7986

1of3

AZD-5582 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide] AZD5582;AZD-5582;AZD 5582 CS-2673 (S,S,2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide) L-Prolinamide, 3,3'-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl- ZD5582 (2S,2'S)-1,1'-((S,2S,2'S)-2,2'-(((1S,1'S,2R,2'R)-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(cyclohexane-3,1-diyl))bis(2-((S)-2-(methylamino)propanamido)acetyl))bis(pyrrolidine-2-carboxamide) (2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide) (2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide) AZD5582 ，S7362 1258392-53-8 C58H78N8O8