2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
- CAS No.
- 1258292-64-6
- Chemical Name:
- 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
- Synonyms
- GDC-046;GDC-046;GDC 046;2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide;Benzamide, 2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-;2,6 Dichloro N (2 (cyclopropanecarboxamido)pyridin 4 yl)benzamide,JAK1,IBD,JAK,2,6DichloroN(2(cyclopropanecarboxamido)pyridin4yl)benzamide,inflammatory,TYK2,bowel,Janus kinase,Inhibitor,inhibit,IL-12,diseases,JAK3,JAK2,IL-23
- CBNumber:
- CB52738245
- Molecular Formula:
- C16H13Cl2N3O2
- Molecular Weight:
- 350.2
- MDL Number:
- MFCD28155087
- MOL File:
- 1258292-64-6.mol
| Product description | Number | Pack Size | Price |
| GDC-046 ≥95% | SYN-1198-M001 | 1mg | $97 |
| GDC-046 | SYN1198 | 1mg | $98.6 |
| 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 98% | A1325556 | 100mg | $383 |
| 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 98% | A1325556 | 250mg | $575 |
| GDC046 >98% | DC8519 | 100mg | $650 |
| More product size | |||
2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1198-M001 | GDC-046 ≥95% | 1258292-64-6 | 1mg | $97 | 2021-12-16 | Buy |
| AK Scientific | SYN1198 | GDC-046 | 1258292-64-6 | 1mg | $98.6 | 2021-12-16 | Buy |
| Ambeed | A1325556 | 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 98% | 1258292-64-6 | 100mg | $383 | 2021-12-16 | Buy |
| Ambeed | A1325556 | 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 98% | 1258292-64-6 | 250mg | $575 | 2021-12-16 | Buy |
| DC Chemicals | DC8519 | GDC046 >98% | 1258292-64-6 | 100mg | $650 | 2021-12-16 | Buy |
2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Chemical Properties,Uses,Production
Uses
GDC-046 is a potent, selective, and orally bioavailable TYK2 inhibitor with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively[1].
in vivo
In mice, GDC-046 exhibits relatively high clearance (65 mL/min/kg) when dosed intravenously (i.v. 1 mg/kg) and exhibits modest oral exposure (AUC=2.6 μM·h at p.o. 5 mg/kg)[1].
IC 50
Tyk2: 4.8 nM (Ki); JAK1: 0.7 nM (Ki); JAK2: 0.7 nM (Ki); JAK3: 0.4 nM (Ki)
References
[1] Jun Liang, et al. Lead Optimization of a 4-aminopyridine Benzamide Scaffold to Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. J Med Chem. 2013 Jun 13;56(11):4521-36. DOI:10.1021/jm400266t
2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24727 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9198 | 58 |
