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3-CHLORO-5-FLUOROPHENOL

3-CHLORO-5-FLUOROPHENOL Structure
3-CHLORO-5-FLUOROPHENOL structure
CAS No.
202982-70-5
Chemical Name:
3-CHLORO-5-FLUOROPHENOL
Synonyms
3-CHLORO-5-FLUOROPHENOL;Phenol, 3-chloro-5-fluoro-;3-Chloro-5-fluorophenol98%;3-Chloro-5-fluorophenol 98%;Phenol, 3-chloro-5-fluoro- (9CI);3-Chloro-4-fluoro-α,α,α-trifluorotoluene;3-CHLORO-5-FLUOROPHENOL ISO 9001：2015 REACH
CBNumber:
CB5273858
Molecular Formula:
C6H4ClFO
Molecular Weight:
146.55
MDL Number:
MFCD00042212
MOL File:
202982-70-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:27:00
Product description Number Pack Size Price
3-Chloro-5-fluorophenol 98% PC8165 1g $21
3-Chloro-5-fluorophenol 98% PC8165 5g $24
3-Chloro-5-fluorophenol 98% PC8165 25g $28
3-Chloro-5-fluorophenol 98% PC8165 1g $21
3-Chloro-5-fluorophenol 98% PC8165 5g $24
More product size
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3-CHLORO-5-FLUOROPHENOL Properties

Boiling point 206.0±20.0 °C(Predicted)
Density 1.408±0.06 g/cm3(Predicted)
refractive index 1.537
storage temp. Inert atmosphere,Room Temperature
pka 8.01±0.10(Predicted)
form liquid
color Clear
Water Solubility Immiscible with water.
CAS DataBase Reference 202982-70-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)Environment (GHS09)
GHS05,GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H312-H314-H318-H401-H411
Precautionary statements  P273-P280-P303+P361+P353-P305+P351+P338-P310
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-22
Safety Statements  26-36/37/39
RIDADR  UN3265
Hazard Note  Irritant
HazardClass  8
HS Code  2908190090
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
3 0

3-CHLORO-5-FLUOROPHENOL price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC8165 3-Chloro-5-fluorophenol 98% 202982-70-5 1g $21 2026-06-04 Buy
Apolloscientific PC8165 3-Chloro-5-fluorophenol 98% 202982-70-5 5g $24 2026-06-04 Buy
Apolloscientific PC8165 3-Chloro-5-fluorophenol 98% 202982-70-5 25g $28 2026-06-04 Buy
Apolloscientific PC8165 3-Chloro-5-fluorophenol 98% 202982-70-5 1g $21 2026-06-04 Buy
Apolloscientific PC8165 3-Chloro-5-fluorophenol 98% 202982-70-5 5g $24 2026-06-04 Buy
Product number Packaging Price Buy
PC8165 1g $21 Buy
PC8165 5g $24 Buy
PC8165 25g $28 Buy
PC8165 1g $21 Buy
PC8165 5g $24 Buy

3-CHLORO-5-FLUOROPHENOL Chemical Properties,Uses,Production

Uses

3-Chloro-5-fluorophenol is used as an intermediate in organic synthesis. It plays an important role in the preparation of substituted amides as antagonists and/or inverse agonists of cannabinoid-1 receptor, substituted N-(arylmethyl)aryloxy arylcarboxamide and heteroarylcarboxamide antagonists for the PGE2 receptor EP4 for the treatment of pain, inflammation, osteoarthritis, and rheumatoid arthritis.

Synthesis

3-CHLORO-5-FLUOROANISOLE

202925-08-4

3-CHLORO-5-FLUOROPHENOL

202982-70-5

The general procedure for the synthesis of 3-chloro-5-fluorophenol from 1-chloro-3-fluoro-5-methoxybenzene was as follows: 3-chloro-5-fluoroanisole (10 g, 62 mmol) was dissolved in dichloromethane (50 mL) under argon protection and the solution was cooled to -70 °C. Boron tribromide (11.8 mL, 124 mmol) was slowly added dropwise at -70 °C under vigorous stirring, and the dropwise process was controlled to be completed within 15 minutes. Upon completion of the reaction, the mixture was gradually warmed to room temperature and the pH was adjusted with saturated sodium bicarbonate solution to 6. Subsequently, the organic and aqueous layers were separated, and the aqueous layer was extracted with dichloromethane (2 x 50 mL). All organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and finally the solvent was evaporated under vacuum to afford the target product 3-chloro-5-fluorophenol (8 g, 88% yield, 54.6 mmol) as a yellow oil. The product was characterized by 1H NMR (DMSO-d6): δ 10.36 (s, 1H, OH), 6.73-6.79 (m, 1H, Ar-H), 6.64-6.68 (m, 1H, Ar-H), 6.53-6.59 (m, 1H, Ar-H).

References

[1] Patent: WO2006/136924, 2006, A1. Location in patent: Page/Page column 133

3-CHLORO-5-FLUOROPHENOL Preparation Products And Raw materials

Raw materials

3-CHLORO-5-FLUOROANISOLE Boron tribromide Water Sodium bicarbonate Dichloromethane

Preparation Products

3-CHLORO-5-FLUOROPHENOL Suppliers

Global( 149)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16512 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14304 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
Fluoropharm Co., Ltd. 		60
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Accela ChemBio Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Fuxin Pharmaceutical 		58
Win-Win chemical CO., Limited 		58

View Lastest Price from 3-CHLORO-5-FLUOROPHENOL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloro-5-fluorophenol pictures 2026-04-17 3-Chloro-5-fluorophenol
202982-70-5
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
3-CHLORO-5-FLUOROPHENOL pictures 2020-01-08 3-CHLORO-5-FLUOROPHENOL
202982-70-5
 $2.00 1g 98%MIN Career Henan Chemical Co
1H-Imidazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)- (9CI) pictures 2020-01-08 1H-Imidazole-4-carboxaldehyde, 5-(1,1-dimethylethyl)- (9CI)
202982-70-5
 $2.00 1g 98%MIN Career Henan Chemical Co

3-CHLORO-5-FLUOROPHENOL Spectrum

3-CHLORO-5-FLUOROPHENOL(202982-70-5)1HNMR3-CHLORO-5-FLUOROPHENOL(202982-70-5)19FNMR

202982-70-5(3-CHLORO-5-FLUOROPHENOL)Related Search:

3-CHLORO-5-FLUOROANISOLE 3-CHLORO-5-FLUOROPHENOL 3-CHLORO-2-FLUOROPHENOL 2,6-DICHLORO-4-FLUOROPHENOL 4-BROMO-2-CHLORO-6-FLUOROPHENOL,4-Bromo-2-chloro-6-fluorophenol 97%
3-Chloro-4-fluorophenol 98%,3-CHLORO-4-FLUOROPHENOL,3-Chloro-4-fluorophenol98% 2,3-DICHLORO-6-FLUOROPHENOL Phenol, 4-amino-2-chloro-3-fluoro- 2-BROMO-4-CHLORO-6-FLUOROPHENOL 2-CHLORO-3-FLUOROPHENOL
2-BROMO-6-CHLORO-4-FLUOROPHENOL 4-Chloro-3-fluorophenol 4-Chloro-2-fluorophenol 2-Chloro-6-fluorophenol 2-Chloro-4-fluorophenol
2-Chloro-5-fluorophenol 3-CHLORO-5-FLUOROPHENETOLE 5-AMINO-2-CHLORO-4-FLUOROPHENOL

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Phenol, 3-chloro-5-fluoro- (9CI) 3-Chloro-5-fluorophenol 98% 3-Chloro-5-fluorophenol98% 3-CHLORO-5-FLUOROPHENOL Phenol, 3-chloro-5-fluoro- 3-CHLORO-5-FLUOROPHENOL ISO 9001：2015 REACH 3-Chloro-4-fluoro-α,α,α-trifluorotoluene 202982-70-5 ALCOHOL HALIDE Aromatic Phenols Phenol&Thiophenol&Mercaptan Chlorine Compounds Fluorine Compounds Phenols