4-HYDROXYISOLEUCINE
- CAS No.
- 55399-93-4
- Chemical Name:
- 4-HYDROXYISOLEUCINE
- Synonyms
- HIL;4-Hydroxyisoleucine;HYDROXYISOLEUCINE, 4-;4 -Hydroxyisoleucic acid;HYDROXYISOLEUCINE, 4-(FG);(4S)-4-Hydroxy-L-isoleucine;Hydroxyisoleucine 55399-93-4;TIANFU-CHEM 4-HYDROXYISOLEUCINE;4-HYDROXYISOLEUCINECAS:55399-93-4;[DISCONTINUED] Replaced by KIT-00008502-0HK
- CBNumber:
- CB5274835
- Molecular Formula:
- C6H13NO3
- Molecular Weight:
- 147.17
- MDL Number:
- MFCD07357252
- MOL File:
- 55399-93-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (4S)-4-Hydroxy-L-isoleucine from fenugreek seed, ≥98.0% (TLC) | 50118 | 50mg | $573 |
| 4-Hydroxyisoleucine | 11812 | 1mg | $68 |
| 4-Hydroxyisoleucine | 11812 | 25mg | $1169 |
| 4-Hydroxyisoleucine | 11812 | 5mg | $302 |
| 4-Hydroxyisoleucine | 11812 | 10mg | $535 |
| More product size | |||
| Melting point | 223-224℃ |
|---|---|
| Boiling point | 331.6±32.0 °C(Predicted) |
| Density | 1.181±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 147℃ |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | 2.41±0.25(Predicted) |
| form | Solid |
| color | White to Off-White |
| biological source | fenugreek seeds |
| optical activity | [α]/D +32.5±2.0°, c = 1 in H2O |
| BRN | 4128096 |
| Cosmetics Ingredients Functions |
SKIN CONDITIONING HUMECTANT |
| InChI | InChI=1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5-/m0/s1 |
| InChIKey | OSCCDBFHNMXNME-YUPRTTJUSA-N |
| SMILES | C(O)(=O)[C@@H](N)[C@@H](C)[C@H](C)O |
| FDA UNII | 4SWT01T54O |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-HYDROXYISOLEUCINE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 50118 | (4S)-4-Hydroxy-L-isoleucine from fenugreek seed, ≥98.0% (TLC) | 55399-93-4 | 50mg | $573 | 2026-03-19 | Buy |
| Cayman Chemical | 11812 | 4-Hydroxyisoleucine | 55399-93-4 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 11812 | 4-Hydroxyisoleucine | 55399-93-4 | 25mg | $1169 | 2024-03-01 | Buy |
| Cayman Chemical | 11812 | 4-Hydroxyisoleucine | 55399-93-4 | 5mg | $302 | 2024-03-01 | Buy |
| Cayman Chemical | 11812 | 4-Hydroxyisoleucine | 55399-93-4 | 10mg | $535 | 2024-03-01 | Buy |
4-HYDROXYISOLEUCINE Chemical Properties,Uses,Production
Description
4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity. It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM. In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and streptozotocin (STZ; ) when administered at 25 mg/kg. 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from fenugreek seeds.
Occurrence
4-hydroxyisoleucine has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties.
Uses
(4S)-4-Hydroxy-L-isoleucine is 4S isomer of 4-Hydroxyisoleucine, which is used as a treatment for type II diabetes.
Definition
ChEBI: An L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent.
Biological Activity
4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range of 100 micromol/l to 1 mmol/l, through a direct effect on isolated islets of Langerhans from both rats and humans.
References
[1] CHRISTOPHE BROCA . 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion[J]. European journal of pharmacology, 2000, 390 3: Pages 339-345. DOI: 10.1016/s0014-2999(00)00030-3
[2] CHRISTOPHE BROCA. Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.[J]. American journal of physiology. Endocrinology and metabolism, 2004, 287 3: E463-71. DOI: 10.1152/ajpendo.00163.2003
[3] MOHAMMED R. HAERI . Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats[J]. Phytomedicine, 2012, 19 7: Pages 571-574. DOI: 10.1016/j.phymed.2012.01.004
4-HYDROXYISOLEUCINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChiRial Biomaterial Co Ltd | +86-19941513806 +86-19941513806 | cero.xia@chirial.com | China | 156 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29822 | 58 |
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 | yklbiotech@163.com | CHINA | 296 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 1169 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2542 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
View Lastest Price from 4-HYDROXYISOLEUCINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | (2S,3R,4S)-4-Hydroxyisoleucine
55399-93-4
|
US $31.00-113.00 / mg | 99.95% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-20 | 4-HYDROXYISOLEUCINE
55399-93-4
|
US $0.00-0.00 / Kg/Drum | 1KG | 90%min | 10KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-06-20 | 4-HYDROXYISOLEUCINE
55399-93-4
|
US $40.00-30.00 / kg | 1kg | 99% | 30 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- (2S,3R,4S)-4-Hydroxyisoleucine
55399-93-4
- US $31.00-113.00 / mg
- 99.95%
- TargetMol Chemicals Inc.
-
- 4-HYDROXYISOLEUCINE
55399-93-4
- US $0.00-0.00 / Kg/Drum
- 90%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-HYDROXYISOLEUCINE
55399-93-4
- US $40.00-30.00 / kg
- 99%
- Hebei Yanxi Chemical Co., Ltd.
