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1-(4-Trifluoromethylphenyl)piperidin-4-ol

1-(4-Trifluoromethylphenyl)piperidin-4-ol Structure
1-(4-Trifluoromethylphenyl)piperidin-4-ol structure
CAS No.
681508-70-3
Chemical Name:
1-(4-Trifluoromethylphenyl)piperidin-4-ol
Synonyms
4-(6-Bromo-pyridin-2-yl)-benzoicacid;1-(4-TRIFLUOROMETHYLPHENYL)PIPERIDIN-4-OL;1-[4-(trifluoromethyl)phenyl]-4-piperidinol;4-Piperidinol, 1-[4-(trifluoromethyl)phenyl]-
CBNumber:
CB5299720
Molecular Formula:
C12H14F3NO
Molecular Weight:
245.24
MDL Number:
MFCD05864752
MOL File:
681508-70-3.mol
Last updated:2025-07-24 18:13:53
Product description Number Pack Size Price
1-(4-Trifluoromethylphenyl)piperidin-4-ol V0025 1g $115
1-(4-Trifluoromethylphenyl)piperidin-4-ol V0025 10g $411
1-(4-Trifluoromethylphenyl)piperidin-4-ol 95+% 071783 5g $500
1-(4-Trifluoromethylphenyl)piperidin-4-ol 95+% 071783 1g $185
1-(4-TRIFLUOROMETHYLPHENYL)PIPERIDIN-4-OL 95.00% COR0001144 1G $202.65
Request For Quotation

1-(4-Trifluoromethylphenyl)piperidin-4-ol Properties

Boiling point 334.3±42.0 °C(Predicted)
Density 1.275±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 14.72±0.20(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26

1-(4-Trifluoromethylphenyl)piperidin-4-ol price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific V0025 1-(4-Trifluoromethylphenyl)piperidin-4-ol 681508-70-3 1g $115 2021-12-16 Buy
AK Scientific V0025 1-(4-Trifluoromethylphenyl)piperidin-4-ol 681508-70-3 10g $411 2021-12-16 Buy
Matrix Scientific 071783 1-(4-Trifluoromethylphenyl)piperidin-4-ol 95+% 681508-70-3 5g $500 2021-12-16 Buy
Matrix Scientific 071783 1-(4-Trifluoromethylphenyl)piperidin-4-ol 95+% 681508-70-3 1g $185 2021-12-16 Buy
American Custom Chemicals Corporation COR0001144 1-(4-TRIFLUOROMETHYLPHENYL)PIPERIDIN-4-OL 95.00% 681508-70-3 1G $202.65 2021-12-16 Buy
Product number Packaging Price Buy
V0025 1g $115 Buy
V0025 10g $411 Buy
071783 5g $500 Buy
071783 1g $185 Buy
COR0001144 1G $202.65 Buy

1-(4-Trifluoromethylphenyl)piperidin-4-ol Chemical Properties,Uses,Production

Synthesis

4-Hydroxypiperidine

5382-16-1

4-Bromobenzotrifluoride

402-43-7

1-(4-Trifluoromethylphenyl)piperidin-4-ol

681508-70-3

Under nitrogen atmosphere, BINAP (187 mg, 0.3 mmol), Pd2(dba)3 (92 mg, 0.1 mmol), sodium tert-butoxide (1.19 g, 12.0 mmol), 4-hydroxypiperidine (Compound 8, 1.14 g, 11.2 mmol), and p-bromobenzotrifluoride (Compound 9, 1.36 mL, 10.0 mmol) were were dissolved in toluene. The reaction mixture was subjected to microwave radiation and reacted at 120°C for 1 hour. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and the solids were washed with ethyl acetate. The filtrate and washings were combined and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford 1-(4-trifluoromethylphenyl)piperidin-4-ol (Compound 10, 1.45 g, 59% yield). The melting point of the product was 97-98 °C. 1H-NMR (CDCl3/TMS) δ ppm: 1.49-1.56 (m, 2H), 1.62-1.74 (m, 2H), 2.03 (brs, 2H), 3.03-3.10 (m, 2H), 3.63-3.71 (m, 2H), 3.93 (brs, 1H), 6.97 ( br, 2H), 7.48 (d, J = 8.7 Hz, 2H).

References

[1] Journal of the American Chemical Society, 2018, vol. 140, # 24, p. 7667 - 7673
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 42, p. 13088 - 13093
[3] Angew. Chem., 2017, vol. 129, p. 13268 - 13273,6
[4] Patent: EP1988077, 2008, A1. Location in patent: Page/Page column 63-64
[5] Patent: WO2010/115688, 2010, A1. Location in patent: Page/Page column 127

1-(4-Trifluoromethylphenyl)piperidin-4-ol synthesis

5382-16-1
402-43-7
681508-70-3
Synthesis of 1-(4-Trifluoromethylphenyl)piperidin-4-ol from 4-Hydroxypiperidine and 4-Bromobenzotrifluoride

1-(4-Trifluoromethylphenyl)piperidin-4-ol Preparation Products And Raw materials

Raw materials

4-Hydroxypiperidine 4-Bromobenzotrifluoride Sodium tert-butoxide Toluene

Preparation Products

1-(4-Trifluoromethylphenyl)piperidin-4-ol Suppliers

Global( 54)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49975 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42943 64
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4267 65
Supplier Advantage
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
Aladdin Scientific 		58
Chongqing Chemdad Co., Ltd 		58
Amadis Chemical Company Limited 		58
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Ennopharm Co., Ltd. 65

View Lastest Price from 1-(4-Trifluoromethylphenyl)piperidin-4-ol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(4-Trifluoromethylphenyl)piperidin-4-ol pictures 2019-07-06 1-(4-Trifluoromethylphenyl)piperidin-4-ol
681508-70-3
 US $8.80 / KG 1KG 97%-99% 100kg Career Henan Chemical Co

1-(4-Trifluoromethylphenyl)piperidin-4-ol Spectrum

1-(4-Trifluoromethylphenyl)piperidin-4-ol(681508-70-3)1HNMR

681508-70-3(1-(4-Trifluoromethylphenyl)piperidin-4-ol)Related Search:

DROPERIDOL TEMPO 2,2,6,6-Tetramethyl-4-piperidinol Haloperidol 1-(2-NITRO-5-TRIFLUOROMETHYLPHENYL)PIPERIDIN-4-OL
(8-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-3-PHENYL-1-OXA-4,8-DIAZASPIRO[4.5]DEC-4-YL)(4-FLUOROPHENYL)METHANONE 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]PIPERIDIN-4-OL 1-[2-amino-4-(trifluoromethyl)phenyl]piperidin-4-ol 8-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-N-(4-METHYLPHENYL)-3-PHENYL-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOXAMIDE 3-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-7,12-DIOXA-3-AZASPIRO[5.6]DODEC-9-ENE
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1-(4-TRIFLUOROMETHYLPHENYL)PIPERIDIN-4-OL 4-(6-Bromo-pyridin-2-yl)-benzoicacid 1-[4-(trifluoromethyl)phenyl]-4-piperidinol 4-Piperidinol, 1-[4-(trifluoromethyl)phenyl]- 681508-70-3 C13H18F3NO