TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
- CAS No.
- 239074-29-4
- Chemical Name:
- TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
- Synonyms
- tert-butyl ((1r,4r)-4-(hydroxymethyl)cyclohexyl)carbamate;tert-Butyl (trans-4-(hydroxymethyl);trans-4-(Boc-amino)cyclohexanemethanol;trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane;trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane,97%;trans-1-(Boc-aMino)-4-(hydroxyMethyl)cyclohexane, 97%;TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE;Trans tert-butyl 4-(hydroxyMethyl)cyclohexyl)carbaMate;Trans-tert-Butyl (4-(hydroxymethyl)cyclohexyl)caCSAmate;trans-4-(tert-Butoxycarbonylamino)cyclohexane-1-methanol
- CBNumber:
- CB5301665
- Molecular Formula:
- C12H23NO3
- Molecular Weight:
- 229.32
- MDL Number:
- MFCD03844605
- MOL File:
- 239074-29-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (trans-4-Hydroxymethylcyclohexyl)carbamicAcidtert-ButylEster | H950080 | 250mg | $205 |
| tert-Butyl trans-4-(hydroxymethyl)cyclohexylcarbamate | FB46677 | 1g | $120 |
| tert-Butyl trans-4-(hydroxymethyl)cyclohexylcarbamate | FB46677 | 500mg | $80 |
| tert-Butyl trans-(4-hydroxymethyl)-cyclohexylcarbamate | 089350 | 500mg | $29 |
| tert-Butyl trans-(4-hydroxymethyl)-cyclohexylcarbamate | 089350 | 1g | $44 |
| More product size | |||
| Boiling point | 351.6±11.0 °C(Predicted) |
|---|---|
| Density | 1.05±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Slightly Soluble (4.4 g/L) (25°C). |
| pka | 12.50±0.40(Predicted) |
| form | Solid |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C12H23NO3/c1-12(2,3)16-11(15)13-10-6-4-9(8-14)5-7-10/h9-10,14H,4-8H2,1-3H3,(H,13,15)/t9-,10- |
| InChIKey | SGNKPJPMWHKOJO-MGCOHNPYSA-N |
| SMILES | C(OC(C)(C)C)(=O)N[C@@H]1CC[C@@H](CO)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H335-H319-H315 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| NFPA 704 |
|
TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H950080 | (trans-4-Hydroxymethylcyclohexyl)carbamicAcidtert-ButylEster | 239074-29-4 | 250mg | $205 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB46677 | tert-Butyl trans-4-(hydroxymethyl)cyclohexylcarbamate | 239074-29-4 | 1g | $120 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB46677 | tert-Butyl trans-4-(hydroxymethyl)cyclohexylcarbamate | 239074-29-4 | 500mg | $80 | 2021-12-16 | Buy |
| Matrix Scientific | 089350 | tert-Butyl trans-(4-hydroxymethyl)-cyclohexylcarbamate | 239074-29-4 | 500mg | $29 | 2021-12-16 | Buy |
| Matrix Scientific | 089350 | tert-Butyl trans-(4-hydroxymethyl)-cyclohexylcarbamate | 239074-29-4 | 1g | $44 | 2021-12-16 | Buy |
TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Chemical Properties,Uses,Production
Uses
trans-1-(Boc-amino)-4-(hydroxymethyl)cyclohexane is used to prepare C-2 hydroxyethyl imidazopyrrolo pyridines as JAK1 inhibitors. It is also used to prepare Mer kinase inhibitors for treatment of pediatric acute lymphoblastic leukemia.
Synthesis
146307-51-9
239074-29-4
General procedure for the synthesis of tert-butyl trans-(4-hydroxymethyl)cyclohexylcarbamate from methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate: a suspension of LiAlH4 (9.0 g, 0.236 mol, 1.12 eq.) in THF (500 mL) was cooled to 0 °C under ice bath conditions. Subsequently, a solution of methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate (54.3 g, 0.21 mol, 1.0 eq.) in THF (200 mL) was slowly added to ensure that the reaction temperature was maintained below 10 °C. After the addition was completed, the reaction mixture was transferred to room temperature and stirred overnight. Upon completion of the reaction, the reaction was carefully quenched with sodium sulfate decahydrate (27 g) at 15 °C to 25 °C. The insoluble material was removed by filtration and the filtrate was concentrated to give tert-butyl trans-(4-hydroxymethyl)cyclohexylcarbamate (43 g, 89% yield) as a white powder.MS-ESI: [M + 1]+: 229.1.
References
[1] Patent: WO2018/67422, 2018, A1. Location in patent: Page/Page column 44; 45
[2] Patent: WO2018/69863, 2018, A1. Location in patent: Page/Page column 121-122
[3] Patent: EP2017261, 2009, A1. Location in patent: Page/Page column 30-31
[4] Patent: US2010/273841, 2010, A1. Location in patent: Page/Page column 22
[5] Patent: WO2011/92293, 2011, A2. Location in patent: Page/Page column 99-100
TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10000 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Pharmahands (Taizhou) Co., Ltd. | +86 523-86200360 | CHINA | 358 | 58 |
View Lastest Price from TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | (trans-4-Hydroxymethylcyclohexyl)carbamic acid tert-butyl ester
239074-29-4
|
US $3.00-9.00 / KG | 0.1KG | 99% | g-kg-tons, free sample is available | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2021-04-08 | TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
239074-29-4
|
US $0.00 / g | 1g | 99% | 200kg/month | Pharmahands (Taizhou) Co., Ltd. | |
 |
2020-01-08 | TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
239074-29-4
|
US $1.00 / KG | 1KG | 99.0% | 100kg | Career Henan Chemical Co |
-
- (trans-4-Hydroxymethylcyclohexyl)carbamic acid tert-butyl ester
239074-29-4
- US $3.00-9.00 / KG
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
239074-29-4
- US $0.00 / g
- 99%
- Pharmahands (Taizhou) Co., Ltd.
-
- TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
239074-29-4
- US $1.00 / KG
- 99.0%
- Career Henan Chemical Co
239074-29-4(TERT-BUTYL TRANS-(4-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE)Related Search:
1of4
