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ChemicalBook >> CAS DataBase List >>1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Structure
1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one structure
CAS No.
1428774-45-1
Chemical Name:
1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one
Synonyms
PF-06459988;EOS-61635;PF-06459988 >=98% (HPLC);1-((3R,4R)-3-(((5-chloro-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one;irreversible,oral,T790M,Inhibitor,EGFR,PF 06459988,PF-06459988,HER1,NSCLC,inhibit,PF06459988,Epidermal growth factor receptor,cancer,ErbB-1;1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one;2-Propen-1-one, 1-[(3R,4R)-3-[[[5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]methyl]-4-methoxy-1-pyrrolidinyl]-
CBNumber:
CB53133463
Molecular Formula:
C19H22ClN7O3
Molecular Weight:
431.88
MDL Number:
MFCD28987462
MOL File:
1428774-45-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Properties

Density 1.50±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (115.77 mM)
pka 11.26±0.50(Predicted)
form Solid
color White to off-white
InChIKey ODMXWZROLKITMS-RISCZKNCSA-N
SMILES ClC1=CNC2=C1C(OC[C@@H]3[C@@H](OC)CN(C(C=C([H])[H])=O)C3)=NC(NC4=CN(C)N=C4)=N2
FDA UNII 5IE92SK9EB
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth DHC77445 PF-06459988 1428774-45-1 50mg $2048.5 2026-06-04 Buy
ChemScene CS-0017709 PF-06459988 99.10% 1428774-45-1 5mg $87 2026-06-04 Buy
ChemScene CS-0017709 PF-06459988 99.10% 1428774-45-1 10mg $152 2026-06-04 Buy
ChemScene CS-0017709 PF-06459988 99.10% 1428774-45-1 25mg $314 2026-06-04 Buy
ChemScene CS-0017709 PF-06459988 99.10% 1428774-45-1 50mg $504 2026-06-04 Buy
Product number Packaging Price Buy
DHC77445 50mg $2048.5 Buy
CS-0017709 5mg $87 Buy
CS-0017709 10mg $152 Buy
CS-0017709 25mg $314 Buy
CS-0017709 50mg $504 Buy

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Chemical Properties, Uses, Production

Uses

PF-06459988 is an orally activity, irreversible and mutant-selective inhibitor of EGFR mutant forms. PF-06459988 demonstrates high potency and specificity to the T790M-containing double mutant EGFRs. PF-06459988 can be used for the research of cancer[1].

Biological Activity

PF-06459988 is an orally available irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms including the secondary acquired resistance mutation T790M. PF-06459988 has minimal activity against wild-type EGFR (WT EGFR).

References

[1] Cheng H, et al. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J Med Chem. 2016 Mar 10;59(5):2005-24. doi: 10.1021/acs.jmedchem.5b01633. Epub 2016 Jan 28. DOI:10.1021/acs.jmedchem.5b01633

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Suppliers

Global Suppliers ( 37)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Jinan elephant international trading co., LTD 13006575422@163.com China 6347 58
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Zhongshan Geometric Biological Technology Co., Ltd. 2953972351@qq.com China 253 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@qq.com China 589 55
Shanghai Biopharmaleader Co., Ltd. +86 18721201413 sales@biopharmaleader.com China 1711 58
Jinan Yaoyan Pharmaceutical Co., Ltd. jnyaoyan@163.com China 3057 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
Supplier Advantage
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
Jinan elephant international trading co., LTD 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Amadis Chemical Company Limited 58
Zhongshan Geometric Biological Technology Co., Ltd. 58
Kaixin Chemical (Hong Kong) Limited 55
Shanghai Biopharmaleader Co., Ltd. 58
Jinan Yaoyan Pharmaceutical Co., Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58

View Latest Price from 1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-06459988 pictures 2026-07-27 PF-06459988
1428774-45-1
 $149.00 98.00% 10g TargetMol Chemicals Inc.
  • PF-06459988 pictures
  • PF-06459988
    1428774-45-1
  • $149.00
  • 98.00%
  • TargetMol Chemicals Inc.

1428774-45-1 (1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one) Related Search:

EGFR Protein, HUMAN (621A.A, HEK293, FC) EGFR protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) HER2/CD340 protein, HUMAN (BIOTINYLATED, HEK293, HIS) HER3 Protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) AZD-9291
Protein Tyrosine Kinase Compound Library

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1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one EOS-61635 1-((3R,4R)-3-(((5-chloro-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one 2-Propen-1-one, 1-[(3R,4R)-3-[[[5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]methyl]-4-methoxy-1-pyrrolidinyl]- PF-06459988 >=98% (HPLC) irreversible,oral,T790M,Inhibitor,EGFR,PF 06459988,PF-06459988,HER1,NSCLC,inhibit,PF06459988,Epidermal growth factor receptor,cancer,ErbB-1 PF-06459988 1428774-45-1