5-Nonyloxytryptamine oxalate
- CAS No.
- 157798-13-5
- Chemical Name:
- 5-Nonyloxytryptamine oxalate
- Synonyms
- Nonyloxytryptamine;JORSCLBFSAAOFR-UHFFFAOYSA-N;Nonyloxytryptamine oxalate >=98% (HPLC);5-Nonyloxytryptamine oxalate, 5-HT1B agonist;2-(5-(Nonyloxy)-1H-indol-3-yl)ethanamine oxalate;5 Nonyloxytryptamine oxalate,5Nonyloxytryptamine oxalate
- CBNumber:
- CB53136772
- Molecular Formula:
- C21H32N2O5
- Molecular Weight:
- 392.5
- MDL Number:
- MOL File:
- 157798-13-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | room temp |
|---|---|
| solubility | DMSO: soluble2mg/mL, clear (warmed) |
| form | powder |
| color | white to yellow to light brown |
| InChI | 1S/C19H30N2O.CH4/c1-2-3-4-5-6-7-8-13-22-17-9-10-19-18(14-17)16(11-12-20)15-21-19;/h9-10,14-15,21H,2-8,11-13,20H2,1H3;1H4 |
| InChIKey | LXACPZFRJZIDDI-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCOC1=CC=C(NC=C2CCN)C2=C1.C |
| UNSPSC Code | 12352116 |
| NACRES | NA.77 |
5-Nonyloxytryptamine oxalate price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1255 | Nonyloxytryptamine oxalate ≥98% (HPLC) | 157798-13-5 | 5mg | $126 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1255 | Nonyloxytryptamine oxalate ≥98% (HPLC) | 157798-13-5 | 25mg | $337 | 2026-04-30 | Buy |
| Cayman Chemical | 21517 | Nonyloxytryptamine (oxalate) ≥98% | 157798-13-5 | 1mg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 21517 | Nonyloxytryptamine (oxalate) ≥98% | 157798-13-5 | 5mg | $106 | 2026-04-30 | Buy |
| Cayman Chemical | 21517 | Nonyloxytryptamine (oxalate) ≥98% | 157798-13-5 | 10mg | $142 | 2026-04-30 | Buy |
5-Nonyloxytryptamine oxalate Chemical Properties, Uses, Production
Description
Nonyloxytryptamine is a potent agonist of the serotonin (5-HT) receptor 5-HT1Dβ with an EC50 value of 68 nM for adenylate cyclase activity in CHOKM6 cells transfected with the human 5-HT1Dβ receptor. It is selective for 5-HT1Dβ over 5-HT1A for its adenylate cyclase activity, with an EC50 greater than 1 μM for 5-HT1A. It binds to 5-HT1Dβ, 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptors in vitro (Kis = 1.2-315 nM). Nonyloxytryptamine also inhibits reovirus-mediated cell death in a dose-dependent manner but has no effect on reovirus attachment or internalization.
Uses
5-Nonyloxytryptamine Oxalate is a selective 5-HT1B agonist.
Definition
ChEBI: 5-nonyloxytryptamine oxalate is an oxalate salt obtained by reaction of 5-nonyloxytryptamine with one equivalent of oxalic acid. 5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). It has a role as a serotonergic agonist. It contains a 5-nonyloxytryptaminium(1+).
Biochem/physiol Actions
Nonyloxytryptamine (5-nonyloxytryptamine) is a potent and selective 5-HT1B receptor agonist. Nonyloxytryptamine is a polysialic acid (PSA) mimick that triggers PSA-mediated functions. Nonyloxytryptamine enhances neurite outgrowth of cultured primary neurons, protects neurons from oxidative stress, enhanced Schwann cell proliferation, reduces migration of astrocytes and enhances myelination in vitro.
References
[1] RICHARD A. GLENNON. 5-(Nonyloxy)tryptamine: A Novel High-Affinity 5-HT1D.beta. Serotonin Receptor Agonist[J]. Journal of Medicinal Chemistry, 1994, 37 18: 2828-2830. DOI: 10.1021/jm00044a001
[2] BERNARDO A MAINOU. Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry.[J]. Journal of Virology, 2015: 8701-8712. DOI: 10.1128/jvi.00739-15
5-Nonyloxytryptamine oxalate Preparation Products And Raw materials
Raw materials
Preparation Products
5-Nonyloxytryptamine oxalate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
