(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
- CAS No.
- 1454847-96-1
- Chemical Name:
- (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
- Synonyms
- (1S)-1-(5-fluoro-2-iodophenyl)ethanol;EOS-60623;-1-(5-fluoro-2-iodophenyl)ethan-1-ol;(S)-1-(2-Iodo-5-fluorophenyl)-ethanol;(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol;(S)-1-(5-fluoro-2-iodophenyl)ehtan-1-ol;(1S)-1-(5-FLUORO-2-IODOPHENYL)ETHAN-1-OL;(S)-5-Fluoro-2-iodo-alpha-methylbenzyl Alcohol;(S)-5-Fluoro-2-iodo-alpha-methylbenzenemethanol;Benzenemethanol, 5-fluoro-2-iodo-α-methyl-, (αS)-
- CBNumber:
- CB53142393
- Molecular Formula:
- C8H8FIO
- Molecular Weight:
- 266.05
- MDL Number:
- MFCD30803240
- MOL File:
- 1454847-96-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (S)-1-(5-Fluoro-2-iodophenyl)ethanol 97%EE | AS145472 | 1g | $26 |
| (S)-1-(5-Fluoro-2-iodophenyl)ethanol 97%EE | AS145472 | 5g | $66 |
| (S)-1-(5-Fluoro-2-iodophenyl)ethanol 97%EE | AS145472 | 25g | $206 |
| (S)-1-(5-Fluoro-2-iodophenyl)ethan-1-ol >98% | F62425 | 1g | $30 |
| (S)-1-(5-Fluoro-2-iodophenyl)ethan-1-ol >98% | F62425 | 5g | $36 |
| More product size | |||
| Boiling point | 275.7±30.0 °C(Predicted) |
|---|---|
| Density | 1.812±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C, protect from light |
| pka | 13.80±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1/C8H8FIO/c1-5(11)7-4-6(9)2-3-8(7)10/h2-5,11H,1H3/t5-/s3 |
| InChIKey | GQGBQRLYBYFVAW-GQMHJJTINA-N |
| SMILES | [C@H](C1C=C(F)C=CC=1I)(O)C |&1:0,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS145472 | (S)-1-(5-Fluoro-2-iodophenyl)ethanol 97%EE | 1454847-96-1 | 1g | $26 | 2026-06-04 | Buy |
| Activate Scientific | AS145472 | (S)-1-(5-Fluoro-2-iodophenyl)ethanol 97%EE | 1454847-96-1 | 5g | $66 | 2026-06-04 | Buy |
| Activate Scientific | AS145472 | (S)-1-(5-Fluoro-2-iodophenyl)ethanol 97%EE | 1454847-96-1 | 25g | $206 | 2026-06-04 | Buy |
| Synthonix | F62425 | (S)-1-(5-Fluoro-2-iodophenyl)ethan-1-ol >98% | 1454847-96-1 | 1g | $30 | 2026-05-06 | Buy |
| Synthonix | F62425 | (S)-1-(5-Fluoro-2-iodophenyl)ethan-1-ol >98% | 1454847-96-1 | 5g | $36 | 2026-05-06 | Buy |
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol Chemical Properties,Uses,Production
Physical Form
Solid or liquid
Uses
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol is an intermediate of Lorlatinib, which is an orally administered inhibitor of ALK and ROS1, two enzymes that play a role in the development of cancer.
Synthesis
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol is synthesised using 5'-Fluoro-2'-iodoacetophenone as a raw material by chemical reaction. The specific synthesis steps are as follows:
A solution of (-)-DIPCI (57.1 g, 178 mmol) in THF (100 ml) was cooled to -20 to -30 C. A solution of compound 1 (31 .3 g, 1 19 mmol) in THF (100 ml) was then added dropwise, via addition funnel (30 min addition). The reaction was left to warm up to RT. After 2 h, the reaction was cooled to -30 C and another portion of (-)-DIPCI (38.0 g, 1 19 mmol) was added. After 30 min, the reaction was allowed to warm to RT and after 1 h, the solvents were removed in vacuo and the residue re-dissolved in MTBE (200 ml). A solution of diethanolamine (31 g, 296 mmol) in ethanol/THF (15 ml/30 ml) was added via addition funnel, to the reaction mixture under an ice bath. The formation of a white precipitate was observed. The suspension was heated at reflux for 2 hours then cooled to room temperature, filtered and the mother liquids concentrated in vacuo. The residue was suspended in heptane/EtOAc (7:3, 200 ml) and again filtered. This procedure was repeated until no more solids could be observed after the liquids were concentrated. The final yellow oil was purified by column chromatography (eluent: cyclohexane/EtOAc- 99:1 to 96:4). The resulting colorless oil was further purified by recrystallisation from heptanes, to give alcohol compound 2 (25 g, 80% yield, 99% purity and 96% ee) as white crystals. 1H NMR (400 MHz, CDCI3) delta 7.73 (dd, 1 H), 7.32 (dd, 1 H), 6.74 (ddd, 1 H), 4.99 - 5.04 (m, 1 H), 2.01 (d, 1 H), 1.44 (d, 3 H). LCMS-ES: No ionization, Purity 99%. Chiral GC (column CP-Chirasil-DexnCB): 96% ee; Rt (minor) 17.7 minutes and Rt (major) 19.4 minutes.
(S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SyncoZymes (Shanghai) Co., Ltd., | +8613681683526 | lchen@syncozymes.com | China | 286 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Synbest Biotech(Hangzhou) Co., Ltd | 86-571-88737065 | sales@synbestech.com | CHINA | 170 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3992 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5745 | 58 |
| Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 | sales@ryanchem.com | China | 169 | 58 |
View Lastest Price from (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-08 | (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
1454847-96-1
|
1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. | ||
 |
2025-12-24 | (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
1454847-96-1
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2025-09-25 | (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
1454847-96-1
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd |
-
- (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
1454847-96-1
- 99%
- Jinan Ruitong Biotech Co., Ltd.
-
- (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
1454847-96-1
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol
1454847-96-1
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
