17β-hydroxy Wortmannin
- CAS No.
- 58053-83-1
- Chemical Name:
- 17β-hydroxy Wortmannin
- Synonyms
- 17β-hydroxy Wortmannin;PI 3-K Inhibitor XI, HWT;17.beta.-hydroxy Wortmannin;XLJORQYAOTYVQS-OGCOKEDGSA-N;17β-hydroxy Wortmannin Exclusive;PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem;3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6(1H)-dione, 11-(acetyloxy)-6b,7,8,9,9a,10,11,11b-octahydro-9-hydroxy-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9S,9aS,11R,11bR)-
- CBNumber:
- CB53152437
- Molecular Formula:
- C23H26O8
- Molecular Weight:
- 430.45
- MDL Number:
- MFCD00939536
- MOL File:
- 58053-83-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem | 528119 | 5mg | $294 |
| 17β-hydroxy Wortmannin ≥98% | 13812 | 500μg | $65 |
| 17β-hydroxy Wortmannin ≥98% | 13812 | 1mg | $119 |
| 17β-hydroxy Wortmannin ≥98% | 13812 | 5mg | $493 |
| 17β-hydroxy Wortmannin ≥98% | 13812 | 10mg | $862 |
| Boiling point | 615.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 0.15 mg/ml |
| form | Off-white solid |
| pka | 14.49±0.70(Predicted) |
| color | off-white |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P260-P262-P264-P270-P271-P280-P284-P301+P310-P330-P302+P352-P304+P340-P320-P361+P364-P403+P233-P405-P501 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
17β-hydroxy Wortmannin price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 528119 | PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem | 58053-83-1 | 5mg | $294 | 2023-01-07 | Buy |
| Cayman Chemical | 13812 | 17β-hydroxy Wortmannin ≥98% | 58053-83-1 | 500μg | $65 | 2026-04-30 | Buy |
| Cayman Chemical | 13812 | 17β-hydroxy Wortmannin ≥98% | 58053-83-1 | 1mg | $119 | 2026-04-30 | Buy |
| Cayman Chemical | 13812 | 17β-hydroxy Wortmannin ≥98% | 58053-83-1 | 5mg | $493 | 2026-04-30 | Buy |
| Cayman Chemical | 13812 | 17β-hydroxy Wortmannin ≥98% | 58053-83-1 | 10mg | $862 | 2026-04-30 | Buy |
17β-hydroxy Wortmannin Chemical Properties,Uses,Production
Description
17β-
Uses
17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM[1]. 17β-Hydroxywortmannin exhibits antitumor activity[2].
in vivo
17β-Hydroxywortmannin (0.1 μg/kg, p.o. for 5 weeks) exhibits activity in osteoclast differentation and prevent an estrogen-deficiency induced bone loss in ovafiectomized OVX rats[1].
17β-Hydroxywortmannin (2.5 mg/kg/week, i.v. for 2 weeks) exhibits antitumor efficacy towards U87MG glioma with a therapeutic index of 26 in human tumor xenografted nude mice[2].
| Animal Model: | ovafiectomized rat[1] |
| Dosage: | 0.1 μg/kg/day |
| Administration: | p.o. for 5 weeks |
| Result: | Reduced the bone loss without significant toxicity. |
| Animal Model: | U87MG glioma xenografted nude mice[2] |
| Dosage: | 2.5 mg/kg/week |
| Administration: | i.v. for 2 weeks |
| Result: | Inhibited tumor growth. |
IC 50
PI3K: 0.5 nM (IC50)
References
[1] Hall TJ, et al., Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro. Calcif Tissue Int. 1995 Apr;56(4):336-8. DOI:10.1007/BF00318056
[2] Zask A, et al., Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23. DOI:10.1021/jm7012858
17β-hydroxy Wortmannin Preparation Products And Raw materials
17β-hydroxy Wortmannin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11972 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29869 | 58 |
| Cayman Chemical Company | -- | sales@caymanchem.com | China | 6838 | 58 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6394 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6594 | 58 |
