Fosravuconazole bis(L-lysine
- CAS No.
- 1035654-66-0
- Chemical Name:
- Fosravuconazole bis(L-lysine
- Synonyms
- Sarecycline Base;Sarecycline free base;Sarecycline Impurity 5;PQJQFLNBMSCUSH-SBAJWEJLSA-N;Fosravuconazole bis(L-lysine;Minocycline Impurity 27 (Sarecycline);2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-, (4S,4aS,5aR,12aS)-
- CBNumber:
- CB53159906
- Molecular Formula:
- C24H29N3O8
- Molecular Weight:
- 487.5
- MDL Number:
- MFCD22648366
- MOL File:
- 1035654-66-0.mol
| Boiling point | 787.0±70.0 °C(Predicted) |
|---|---|
| Density | 1.53±0.1 g/cm3(Predicted) |
| pka | 4.50±1.00(Predicted) |
| FDA UNII | 94O110CX2E |
Fosravuconazole bis(L-lysine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FS180986 | Sarecycline | 1035654-66-0 | 2mg | $250 | 2026-06-04 | Buy |
| Biosynth | FS180986 | Sarecycline | 1035654-66-0 | 1mg | $250 | 2026-06-04 | Buy |
| Biosynth | FS180986 | Sarecycline | 1035654-66-0 | 5mg | $298.55 | 2026-06-04 | Buy |
| Biosynth | FS180986 | Sarecycline | 1035654-66-0 | 10mg | $454.3 | 2026-06-04 | Buy |
| Biosynth | FS180986 | Sarecycline | 1035654-66-0 | 25mg | $876.25 | 2026-06-04 | Buy |
Fosravuconazole bis(L-lysine Chemical Properties, Uses, Production
Uses
Sarecycline-d6 Hydrochloride is a labelled analogue of Sarecycline Hydrochloride(S140525), which is a substituted tetracycline compound used for treatment of bacterial infections and neoplasms.
in vivo
Sarecycline hydrochloride (0.33-9 mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].
Sarecycline can inhibit S. aureus (PD50=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model[6].
| Animal Model: | Carrageenan-induced footpad edema male Sprague Dawley rats model[6] |
| Dosage: | 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw. |
| Result: | Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline. |
| Animal Model: | Carrageenan-induced footpad edema male Sprague Dawley rats model[6] |
| Dosage: | 0.33, 1, 3, or 9mg/kg |
| Administration: | Intravenously |
| Result: | Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32mg/kg, respectively. |
IC 50
Tetracycline
Fosravuconazole bis(L-lysine Preparation Products And Raw materials
Fosravuconazole bis(L-lysine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@yongstandards.com | China | 9995 | 55 |
| SuZhou Medinoah Co.,LTD. | 0512-69561983 13914027025 | zhang_q@medinoah.com | China | 3925 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29091 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15030 | 58 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 020-36607679; 13502246435 | 3008233746@qq.com | China | 9968 | 12 |
| Jinan blalong chemical co. LTD | 2710913286@qq.com | 1513643261@qq.com | China | 14227 | 58 |
