E-7090
- CAS No.
- 1622204-21-0
- Chemical Name:
- E-7090
- Synonyms
- tasurgratinib;E-7090;E7090 (E 7090);1H-Indole-1-carboxamide, 5-[[2-[[4-[1-(2-hydroxyethyl)-4-piperidinyl]benzoyl]amino]-4-pyridinyl]oxy]-6-(2-methoxyethoxy)-N-methyl-
- CBNumber:
- CB53166236
- Molecular Formula:
- C32H37N5O6
- Molecular Weight:
- 587.67
- MDL Number:
- MFCD32204515
- MOL File:
- 1622204-21-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| form | Solid |
|---|---|
| color | White to off-white |
| FDA UNII | TN7CUD1NGA |
E-7090 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0021430 | E7090 98.11% | 1622204-21-0 | 5mg | $769 | 2026-06-04 | Buy |
| ChemScene | CS-0021430 | E7090 98.11% | 1622204-21-0 | 10mg | $1246 | 2026-06-04 | Buy |
| ChemScene | CS-0021430 | E7090 98.11% | 1622204-21-0 | 25mg | $2167 | 2026-06-04 | Buy |
| ChemScene | CS-0021430 | E7090 98.11% | 1622204-21-0 | 50mg | $3250 | 2026-06-04 | Buy |
| ChemScene | CS-0021430 | E7090 98.11% | 1622204-21-0 | 100mg | $4875 | 2026-06-04 | Buy |
E-7090 Chemical Properties, Uses, Production
Uses
E7090 is an orally available, potent, and selective FGFR inhibitor with IC50s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/FGFR2/FGFR3/FGFR4, respectively[1].
in vivo
Pharmacodynamics analysis reveals that E7090 inhibits phosphorylation of FGFRs in SNU-16 xenograft tumors in a dose-dependent manner[1].
E7090 (6.25-50 mg/kg, orally, once daily) treatment prolongs survival in a 4T1 mouse lung metastasis model[2].
| Animal Model: | Mouse xenograft model of SNU-16 human gastric cancer[2] |
| Dosage: | 6.25 to 50 mg/kg |
| Administration: | Orally, once daily for 14 days |
| Result: | Inhibited tumor growth in a dose-dependent manner. |
IC 50
FGFR1: 0.71 nM (IC50); FGFR2: 0.50 nM (IC50); FGFR3: 1.2 nM (IC50); FGFR4: 120 nM (IC50)
References
[1] Saori Watanabe Miyano, et al. E7090: A potent and selective FGFR inhibitor with activity in multiple FGFR-driven cancer models with distinct mechanisms of activation. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.
[2] Saori Watanabe Miyano, et al. E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models. Mol Cancer Ther. 2016 Nov;15(11):2630-2639. DOI:10.1158/1535-7163.MCT-16-0261
E-7090 Preparation Products And Raw materials
Raw materials
Preparation Products
E-7090 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Hangzhou ChangCun Biotechnology Co., Ltd. | 0571-; 13567100326 | 158848739@qq.com | China | 108 | 50 |
| Zhongshan Geometric Biological Technology Co., Ltd. | 2953972351@qq.com | China | 253 | 58 | |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1883 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9867 | 58 |
