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2-N-HEXYL-4-PENTYNOIC ACID

2-N-HEXYL-4-PENTYNOIC ACID Structure
2-N-HEXYL-4-PENTYNOIC ACID structure
CAS No.
96017-59-3
Chemical Name:
2-N-HEXYL-4-PENTYNOIC ACID
Synonyms
Hexyl-4-pentynoic Acid;2-Hexyl-4-pentynoic Acid;2-PROPARGYLOCTANOIC ACID;2-Hexyl-4-pentynoicAcid>2-N-HEXYL-4-PENTYNOIC ACID;2-(2-PROPYNYL)OCTANOIC ACID;Hexyl-4-pentynoic acid (HPA);R-2-(2-propynyl)octanoic acid;2-(2-Propyn-1-yl)octanoic Acid;2-(Prop-2-yn-1-yl)octanoic acid
CBNumber:
CB5317246
Molecular Formula:
C11H18O2
Molecular Weight:
182.26
MDL Number:
MFCD00946863
MOL File:
96017-59-3.mol
MSDS File:
SDS
Last updated:2026-01-05 11:31:08
Product description Number Pack Size Price
2-Hexyl-4-pentynoic Acid >95.0%(T) H0964 5g $314
2-Hexyl-4-pentynoic Acid >95.0%(T) H0964 25g $1002
2-hexyl-4-Pentynoic Acid ≥95% 15205 1g $120
2-hexyl-4-Pentynoic Acid ≥95% 15205 5g $257
2-hexyl-4-Pentynoic Acid ≥95% 15205 250mg $44
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2-N-HEXYL-4-PENTYNOIC ACID Properties

Boiling point 287.1±23.0 °C(Predicted)
Density 0.94
refractive index 1.4450-1.4510
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka 4.24±0.21(Predicted)
form oil
color Colorless
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xn
Risk Statements  22
HS Code  2916.19.3000
NFPA 704
0
2 0

2-N-HEXYL-4-PENTYNOIC ACID price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical H0964 2-Hexyl-4-pentynoic Acid >95.0%(T) 96017-59-3 5g $314 2025-07-31 Buy
TCI Chemical H0964 2-Hexyl-4-pentynoic Acid >95.0%(T) 96017-59-3 25g $1002 2025-07-31 Buy
Cayman Chemical 15205 2-hexyl-4-Pentynoic Acid ≥95% 96017-59-3 1g $120 2024-03-01 Buy
Cayman Chemical 15205 2-hexyl-4-Pentynoic Acid ≥95% 96017-59-3 5g $257 2024-03-01 Buy
Cayman Chemical 15205 2-hexyl-4-Pentynoic Acid ≥95% 96017-59-3 250mg $44 2024-03-01 Buy
Product number Packaging Price Buy
H0964 5g $314 Buy
H0964 25g $1002 Buy
15205 1g $120 Buy
15205 5g $257 Buy
15205 250mg $44 Buy

2-N-HEXYL-4-PENTYNOIC ACID Chemical Properties,Uses,Production

Description

2-hexyl-4-Pentynoic acid is a derivative of valproic acid , an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 μM. It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 μM.

Uses

2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons[1]. 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1] DANIEL EIKEL  Heinz N  Alfonso Lampen. Teratogenic Effects Mediated by Inhibition of Histone Deacetylases: Evidence from Quantitative Structure Activity Relationships of 20 Valproic Acid Derivatives[J]. Chemical Research in Toxicology, 2006, 19 2: 272-278. DOI:10.1021/tx0502241
[2] YAN LENG . Potent neuroprotective effects of novel structural derivatives of valproic acid: Potential roles of HDAC inhibition and HSP70 induction[J]. Neuroscience Letters, 2010, 476 3: Pages 127-132. DOI:10.1016/j.neulet.2010.04.013

2-N-HEXYL-4-PENTYNOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

2-N-HEXYL-4-PENTYNOIC ACID Suppliers

Global( 65)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shanghai Scibiotron Pharmaceutical Co., Ltd 		+86-16621589600 contact@scibiotron.com China 5217 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
J & K SCIENTIFIC LTD. 18210857532; 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40228 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24529 81
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18729 57
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Aladdin Scientific 		58
Shanghai Scibiotron Pharmaceutical Co., Ltd 		58
Amadis Chemical Company Limited 		58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Shandong Xiya Chemical Co., Ltd 57

View Lastest Price from 2-N-HEXYL-4-PENTYNOIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-hexyl-4-Pentynoic Acid pictures 2026-01-05 2-hexyl-4-Pentynoic Acid
96017-59-3
 US $56.00-198.00 / mg 98.00% 10g TargetMol Chemicals Inc.

2-N-HEXYL-4-PENTYNOIC ACID Spectrum

2-N-HEXYL-4-PENTYNOIC ACID(96017-59-3)1HNMR

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2-N-HEXYL-4-PENTYNOIC ACID

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2-(2-PROPYNYL)OCTANOIC ACID 2-N-HEXYL-4-PENTYNOIC ACID 2-PROPARGYLOCTANOIC ACID 2-Hexyl-4-pentynoic Acid 2-(Prop-2-yn-1-yl)octanoic acid 2-Propargyloctanoic Acid 2-(2-Propynyl)octanoic Acid Hexyl-4-pentynoic acid (HPA) R-2-(2-propynyl)octanoic acid Hexyl-4-pentynoic Acid 2-Hexyl-4-pentynoicAcid> HDAC inhibitor,Heat shock proteins,HSP70,Excitotoxicity,Histone deacetylases,inhibit,HDAC,Neuroprotection,2hexyl4Pentynoic Acid,2 hexyl 4 Pentynoic Acid,Inhibitor,Glutamate,HSP,Valproic acid Octanoic acid, 2-(2-propyn-1-yl)- 2-(2-Propyn-1-yl)octanoic Acid 96017-59-3 Acetylenic Carboxylic Acids & Their Derivatives Acetylenes Acetylenic Carboxylic Acids & Their Derivatives Acetylenes