4-FLUOROCINNAMALDEHYDE
- CAS No.
- 51791-26-5
- Chemical Name:
- 4-FLUOROCINNAMALDEHYDE
- Synonyms
- trans-4-FluorocinnaMaldehyde;CHEMBRDG-BB 4004292;Fluorocinnamaldehyde;(E)-3-(4-Fluorophenyl)-2-propenal;TRANS-4-FLUOROCINNAMALDEHYDE, 97%;trans-4-Fluorocinnamaldehyde;2-PROPENAL, 3-(4-FLUOROPHENYL)-,(2E)
- CBNumber:
- CB5320048
- Molecular Formula:
- C9H7FO
- Molecular Weight:
- 150.15
- MDL Number:
- MFCD03425895
- MOL File:
- 51791-26-5.mol
- MSDS File:
- SDS
| Boiling point | 245.6±15.0 °C(Predicted) |
|---|---|
| Density | 1.146 g/mL at 25 °C |
| refractive index | n20/D 1.599 |
| Flash point | >110°C |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | liquid |
| InChI | 1S/C9H7FO/c10-9-5-3-8(4-6-9)2-1-7-11/h1-7H/b2-1+ |
| InChIKey | YSIYEWBILJZDQH-OWOJBTEDSA-N |
| SMILES | Fc1ccc(\C=C\C=O)cc1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H318 |
| Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 |
4-FLUOROCINNAMALDEHYDE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 683027 | trans-4-Fluorocinnamaldehyde 95% | 51791-26-5 | 500mg | $164 | 2026-04-30 | Buy |
| Biosynth | FF78843 | trans-4-Fluorocinnamaldehyde | 51791-26-5 | 100mg | $196 | 2026-06-04 | Buy |
| Biosynth | FF78843 | trans-4-Fluorocinnamaldehyde | 51791-26-5 | 250mg | $312.5 | 2026-06-04 | Buy |
| Biosynth | FF78843 | trans-4-Fluorocinnamaldehyde | 51791-26-5 | 500mg | $470 | 2026-06-04 | Buy |
| Biosynth | FF78843 | trans-4-Fluorocinnamaldehyde | 51791-26-5 | 1000mg | $860 | 2026-06-04 | Buy |
4-FLUOROCINNAMALDEHYDE Chemical Properties,Uses,Production
Uses
trans-4-Fluorocinnamaldehyde is a reagent used in the preparation of novel terminal bipheny-based diapophytoene desaturases which are used in the treatment of Staphylococcus aureus infections.
Synthesis
459-57-4
2136-75-6
51791-26-5
GENERAL STEPS: 4-Fluorobenzaldehyde (9.40 g, 75.8 mmol) and formylmethylenetriphenylphosphorane (30.0 g, 98.6 mmol) were suspended in toluene (150 mL), and the reaction was stirred for 12 hours at 70 °C. After completion of the reaction, the reaction mixture was treated with ethyl acetate (EtOAc) and water (H2O). The organic layer was separated, washed with saturated saline (brine), dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The residue was purified by column chromatography to afford unsaturated aldehyde (8.04 g, 71% yield). The resulting aldehyde (8.04 g, 53.5 mmol) was dissolved in a solvent mixture of pyridine (100 mL) and dichloromethane (50 mL) at 0 °C and iodine monochloride (17.4 g, 107 mmol) was added. After stirring at 0 °C for 5 h, the reaction was quenched with aqueous sodium thiosulfate (Na2S2O3) and treated with ethyl acetate (EtOAc). The organic layer was separated, washed with saturated saline (brine), dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The residue was purified by column chromatography to afford p-fluorocinnamaldehyde (10.01 g, 68% yield).1H-NMR (300 MHz, DMSO-d6) δ: 7.43 (2H, t, J = 8.5 Hz), 8.13 (2H, dd, J = 8.5, 5.5 Hz), 8.54 (1H, s), 8.84 (1H, s).
References
[1] Patent: WO2007/77961, 2007, A2. Location in patent: Page/Page column 302-303
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 8, p. 1910 - 1913
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 3, p. 719 - 725
4-FLUOROCINNAMALDEHYDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9904 | 55 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
| Taian Jiaye Biotechnology Co.Ltd | 15318151873;13127280945 | 285424065@qq.com | China | 9961 | 55 |
| Shanghai Aoyeah Chemical Technology Co., Ltd. | 021-021-64367138 15900495324 | sales@aoyeahchem.com | China | 196 | 55 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
View Lastest Price from 4-FLUOROCINNAMALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-26 | trans-4-FluorocinnaMaldehyde
51791-26-5
|
100G | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
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- trans-4-FluorocinnaMaldehyde
51791-26-5
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
