Nifekalant
- CAS No.
- 130636-43-0
- Chemical Name:
- Nifekalant
- Synonyms
- NIFEKALANT;Nifekalant-d4;NIFEKALANT HCL;Nifekalant USP/EP/BP;OEBPANQZQGQPHF-UHFFFAOYSA-N;1-(3,4-dichlorophenyl)-3-hexylurea;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylami...;6-((2-((2-hydroxyethyl)(3-(p-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethyl-uracil;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethyl-pyrimidine-2,4-dione;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethyl-pyrimidine-2,4-quinone
- CBNumber:
- CB5325412
- Molecular Formula:
- C19H27N5O5
- Molecular Weight:
- 405.45
- MDL Number:
- MFCD00892243
- MOL File:
- 130636-43-0.mol
- MSDS File:
- SDS
| Melting point | 117.5-118.5°; mp 125-126° (Katakami, 1992) |
|---|---|
| Boiling point | 597.9±60.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| pka | 14.74±0.10(Predicted) |
| CAS DataBase Reference | 130636-43-0(CAS DataBase Reference) |
| FDA UNII | 5VZ7GZM43E |
Nifekalant Chemical Properties,Uses,Production
Uses
Nifekalant (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 μM. Nifekalant can be used for refractory ventricular tachyarrhythmias research[1][2].
Definition
ChEBI: Nifekalant is an amine.
in vivo
In rats (a species deficient in functional cardiac IK), before coronary ligation, 3 mg/kg and 10 mg/kg MS-551 decreased the heart rate by 6% and 12%, and increased mean arterial pressure (MAP) by 14% and 33%, respectively. MS-551 prolongs the QT interval and reduced the incidence of sustained ventricular fibrillation (VF) after reperfusion[3].
References
[1] Lü-Pei Du, et al. The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4771-7. DOI:10.1016/j.bmcl.2004.06.070
[2] Ioannis N Pantazopoulos, et al. Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias. World J Cardiol. 2011 Jun 26;3(6):169-76. DOI:10.4330/wjc.v3.i6.169
[3] J Chen, et al. IK independent class III actions of MS-551 compared with sematilide and dofetilide during reperfusion in anaesthetized rats. Br J Pharmacol. 1996 Nov;119(5):937-42. DOI:10.1111/j.1476-5381.1996.tb15762.x
Nifekalant Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8006 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 1000 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49977 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
View Lastest Price from Nifekalant manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-22 | Nifekalant-d4 | US $571.00-2850.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2019-07-06 | Nifekalant
130636-43-0
|
US $1.00 / KG | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- Nifekalant-d4
- US $571.00-2850.00 / mg
- TargetMol Chemicals Inc.
-
- Nifekalant
130636-43-0
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
