PBI-4050 Sodium salt
- CAS No.
- 1254472-97-3
- Chemical Name:
- PBI-4050 Sodium salt
- Synonyms
- Fezagepras (sodium);PBI-4050 Sodium salt;Setogepram sodium salt;Fezagepras sodium, 10 mM in DMSO
- CBNumber:
- CB53312796
- Molecular Formula:
- C13H19NaO2
- Molecular Weight:
- 230.28
- MDL Number:
- MFCD31657323
- MOL File:
- 1254472-97-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | Water : ≥ 100 mg/mL (438.10 mM);DMSO : ≥ 64 mg/mL (280.38 mM) |
| form | Solid |
| color | White to off-white |
| FDA UNII | R05571KE07 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H373-H315 |
| Precautionary statements | P260-P314-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
PBI-4050 Sodium salt price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42912 | PBI-4050 (sodium salt) ≥98% | 5mg | $109 | 2026-04-30 | Buy | |
| Cayman Chemical | 42912 | PBI-4050 (sodium salt) ≥98% | 10mg | $196 | 2026-04-30 | Buy | |
| Cayman Chemical | 42912 | PBI-4050 (sodium salt) ≥98% | 25mg | $355 | 2026-04-30 | Buy | |
| Cayman Chemical | 42912 | PBI-4050 (sodium salt) ≥98% | 50mg | $545 | 2026-04-30 | Buy | |
| Biosynth | EAC47297 | PBI-4050 sodium | 1254472-97-3 | 5mg | $397.3 | 2026-06-04 | Buy |
PBI-4050 Sodium salt Chemical Properties, Uses, Production
Uses
Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84[1]. Fezagepras sodium decreases renal, liver and pancreatic fibrosis[1][2]. Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions[2].
in vivo
Fezagepras sodium (100 mg/kg/day; gavage from 8-20 weeks of age) markedly decreases hyperglycemia and markedly improvea glucose tolerance in type 2 diabetes eNOS-/-db/db mice[1].·
| Animal Model: | Type 2 diabetes eNOS-/-db/db mice[1] |
| Dosage: | 100 mg/kg/day |
| Administration: | Given via daily gavage from 8-20 weeks |
| Result: | Compared with vehicle-treated mice, hyperglycemia was markedly decreased, and glucose tolerance was markedly improved. |
References
[1] Li Y, et al. Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control. JCI Insight. 2018 May 17;3(10). pii: 120365. DOI:10.1172/jci.insight.120365
[2] Grouix B, et al. PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway. J Pharmacol Exp Ther. 2018 Oct;367(1):71-81. DOI:10.1124/jpet.118.250068
PBI-4050 Sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
PBI-4050 Sodium salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1782 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1883 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
View Latest Price from PBI-4050 Sodium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Fezagepras sodium
1254472-97-3
|
$36.00-143.00 | 99.59% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | Fezagepras sodium
1254472-97-3
|
$36.00-143.00 | 99.59% | 10g | TargetMol Chemicals Inc. |
-
- Fezagepras sodium
1254472-97-3
- $36.00-143.00
- 99.59%
- TargetMol Chemicals Inc.
-
- Fezagepras sodium
1254472-97-3
- $36.00-143.00
- 99.59%
- TargetMol Chemicals Inc.
