Sotalol D6 HCl
- CAS No.
- 1246820-85-8
- Chemical Name:
- Sotalol D6 HCl
- Synonyms
- Sotalol D6 HCl;[2H6]-Sotalol HCl;D6-Sotalol Hydrochloride;[2H6]- Sotalol Hydrochloride;(±)-Sotalol-d6 hydrochloride (dimethyl-d6);Sotalol hydrochloride D6 100 μg/mL in Water;(±)-Sotalol-d6 hydrochloride (dimethyl-d6) in methanol
- CBNumber:
- CB53313177
- Molecular Formula:
- C12H21ClN2O3S
- Molecular Weight:
- 308.82
- MDL Number:
- MFCD04972578
- MOL File:
- 1246820-85-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Sotalol D6 HCl price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29097 | Sotalol-d6 (hydrochloride) ≥99%deuteratedforms(d1-d6); | 1246820-85-8 | 1mg | $336 | 2026-04-30 | Buy |
| Cayman Chemical | 29097 | Sotalol-d6 (hydrochloride) ≥99%deuteratedforms(d1-d6); | 1246820-85-8 | 5mg | $1091 | 2026-04-30 | Buy |
| TRC | TRC-S677302-1MG | Sotalol-d6 Hydrochloride >95%(HPLC) | 1246820-85-8 | 1mg | $277 | 2026-06-03 | Buy |
| TRC | TRC-S677302-10MG | Sotalol-d6 Hydrochloride >95%(HPLC) | 1246820-85-8 | 10mg | $2016 | 2026-06-03 | Buy |
| ChemScene | CS-0112134 | Sotalol-d6 hydrochloride 98.01% | 1246820-85-8 | 1mg | $273 | 2026-06-04 | Buy |
Sotalol D6 HCl Chemical Properties, Uses, Production
Description
Sotalol-d6 is intended for use as an internal standard for the quantification of sotalol by GC- or LC-MS. Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).
Uses
A labelled potent α-adrenergic receptor antagonist. A class III antiarrythmic. It has been shown to prolong action potential and increases the refractory period.
References
[1] RANDALL LIS. Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity[J]. Journal of Medicinal Chemistry, 1990, 33 10: 2883-2891. DOI: 10.1021/jm00172a033
[2] BS M J A, PHD Allen G B, PHD. Pharmacology, pharmacodynamics and pharmacokinetics of sotalol[J]. American Journal of Cardiology, 1990, 65 2: Pages 12-21. DOI: 10.1016/0002-9149(90)90196-8
[3] KATSUHIDE KOMEICHI. Effects of N-acetylprocainamide and sotalol on ion currents in isolated guinea-pig ventricular myocytes[J]. European journal of pharmacology, 1990, 187 3: Pages 313-322. DOI: 10.1016/0014-2999(90)90358-d
Sotalol D6 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
Sotalol D6 HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Artis Biotech Co. Ltd. | 18108108965 18108108965 | sales@artisbio.com | China | 2503 | 58 |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2444 | 58 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9383 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24318 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | offer.de@lgcgroup.com | China | 19036 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4721 | 58 |
