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ChemicalBook >> CAS DataBase List >>N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide Structure
N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide structure
CAS No.
1693731-40-6
Chemical Name:
N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide
Synonyms
CS-2478;CCT251236;CCT-251236,CCT251236;CCT251236;CCT-251236;CCT 251236;N-[5-(2,3-dihydro-1,4-benzodioxine-6-amido)-2-methylphenyl]-2-[2-(pyrrolidin-1-yl)ethoxy]quinoline-6-carboxamide;N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide;N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide;6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-
CBNumber:
CB53313182
Molecular Formula:
C32H32N4O5
Molecular Weight:
552.62
MDL Number:
MFCD30738050
MOL File:
1693731-40-6.mol
MSDS File:
SDS
Last updated:2026-04-17 13:05:51
Product description Number Pack Size Price
CCT251236 27788 1mg $37
CCT251236 27788 25mg $573
CCT251236 27788 5mg $151
CCT251236 27788 10mg $283
CCT251236 >99.0% CS-6956 5mg $396
More product size
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N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide Properties

Boiling point 628.7±55.0 °C(Predicted)
Density 1.328±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (5 mg/ml)
form solid
pka 12.18±0.70(Predicted)
color Off-white/beige
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280
NFPA 704
0
2 0

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27788 CCT251236 1693731-40-6 1mg $37 2024-03-01 Buy
Cayman Chemical 27788 CCT251236 1693731-40-6 25mg $573 2024-03-01 Buy
Cayman Chemical 27788 CCT251236 1693731-40-6 5mg $151 2024-03-01 Buy
Cayman Chemical 27788 CCT251236 1693731-40-6 10mg $283 2024-03-01 Buy
ChemScene CS-6956 CCT251236 >99.0% 1693731-40-6 5mg $396 2021-12-16 Buy
Product number Packaging Price Buy
27788 1mg $37 Buy
27788 25mg $573 Buy
27788 5mg $151 Buy
27788 10mg $283 Buy
CS-6956 5mg $396 Buy

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide Chemical Properties,Uses,Production

Description

CCT251236 (1693731-40-6) is an inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2

Uses

CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction.

in vivo

CCT251236 (oral adminstation; 5 or 20 mg/kg) in nontumor bearing immunocompetent BALB/c mice exhibits free Cav0-24h value of 2.0 nM and 1.2 nM, respectively[2]. CCT251236 (oral adminstation; 20 mg/kg; 33 days) has a clear therapeutic efficacy in mice with a tumor growth inhibition (%TGI) of 70% based on final tumor volumes. After 33 days, the mean tumor weights decreases 64% when compares to control group. In addition, the compound’s basicity and high volume of distribution shows in tumor withtumor concentrations of CCT251236 as high as 940 nM[2].

Animal Model:Athymic mice with SK-OV-3 cells[2]
Dosage:20 mg/kg; 33 days
Administration:Oral adminstation
Result:Was efficacious in SK-OV-3 cell induced-tumor mice model.

IC 50

HSP72: 19 nM (IC50, SK-OV-3 cells)

References

[1] MATTHEW D. CHEESEMAN. Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen[J]. Journal of Medicinal Chemistry, 2016, 60 1: 180-201. DOI:10.1021/acs.jmedchem.6b01055
[2] JACQUELINE H L FOK. HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.[J]. Clinical Cancer Research, 2018, 24 10: 2395-2407. DOI:10.1158/1078-0432.ccr-17-1594

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30227 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Hong Kong Tiansheng New Material Trading Co., Ltd 		+8617320695765 zxx@hktiansheng.com China 973 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6003 61
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Hong Kong Tiansheng New Material Trading Co., Ltd 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Chembest Research Laboratories Limited 61

View Lastest Price from N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CCT251236 pictures 2026-04-17 CCT251236
1693731-40-6
 US $31.00 / mg 99.89% 10g TargetMol Chemicals Inc.
CCT251236 pictures 2025-12-22 CCT251236
1693731-40-6
 US $33.00 / mg 99.89% 10g TargetMol Chemicals Inc.
CCT251236 pictures 2022-02-25 CCT251236
1693731-40-6
 US $100.00 / KG 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
  • CCT251236 pictures
  • CCT251236
    1693731-40-6
  • US $31.00 / mg
  • 99.89%
  • TargetMol Chemicals Inc.
  • CCT251236 pictures
  • CCT251236
    1693731-40-6
  • US $33.00 / mg
  • 99.89%
  • TargetMol Chemicals Inc.
  • CCT251236 pictures
  • CCT251236
    1693731-40-6
  • US $100.00 / KG
  • 98%
  • Hong Kong Tiansheng New Material Trading Co., Ltd

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide Spectrum

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide(1693731-40-6)1HNMR

1693731-40-6(N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide)Related Search:

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CCT251236 N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide CS-2478 CCT251236;CCT-251236;CCT 251236 6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]- CCT-251236,CCT251236 N-[5-(2,3-dihydro-1,4-benzodioxine-6-amido)-2-methylphenyl]-2-[2-(pyrrolidin-1-yl)ethoxy]quinoline-6-carboxamide 1693731-40-6