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ChemicalBook >> CAS DataBase List >>ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Structure
ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate structure
CAS No.
1596348-32-1
Chemical Name:
ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate
Synonyms
159142;KDOAM 21;KDM5 inhibitor C70;KDOAM-21 (KDM5-C70);KDM5-C70, 10 mM in DMSO;KDM5-C70(KDM5inhibitorC70);ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate;4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, ethyl ester;KDM5-C49,Histone Demethylase,JARID1,retinoblastoma,inhibit,KDM5 C70,KDM5-C70,KDM-5-C70,phosphorylation,KDM5C70,KDM5,Inhibitor,H3K4me3,antiproliferative
CBNumber:
CB53334347
Molecular Formula:
C17H28N4O3
Molecular Weight:
336.42922
MDL Number:
MFCD30721931
MOL File:
1596348-32-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
KDM5-C70 ≥98.0% CS-0077883 25mg $175
KDM5-C70 ≥98.0% CS-0077883 100mg $645
KDM5-C70 ≥98.0% CS-0077883 250mg $1295
KDM5-C70 >98% DC23376 250mg $1300
KDM5-C70 >98% DC23376 1g $2600
Request For Quotation

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Properties

Boiling point 466.6±45.0 °C(Predicted)
Density 1.099±0.06 g/cm3(Predicted)
storage temp. -10 to -25°C
solubility Chloroform: soluble; DMSO: soluble; Ethanol: soluble
pka 8.39±0.28(Predicted)
form Liquid
color Light yellow to yellow
InChI 1S/C17H28N4O3/c1-5-21(10-9-20(3)4)16(22)13-18-12-15-11-14(7-8-19-15)17(23)24-6-2/h7-8,11,18H,5-6,9-10,12-13H2,1-4H3
InChIKey WCILOMUUNVPIKQ-UHFFFAOYSA-N
SMILES CN(CCN(C(CNCC1=CC(C(OCC)=O)=CC=N1)=O)CC)C
FDA UNII 4288BE400F
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319
Precautionary statements  P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
NFPA 704
3
2 0

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0077883 KDM5-C70 ≥98.0% 1596348-32-1 25mg $175 2021-12-16 Buy
ChemScene CS-0077883 KDM5-C70 ≥98.0% 1596348-32-1 100mg $645 2021-12-16 Buy
ChemScene CS-0077883 KDM5-C70 ≥98.0% 1596348-32-1 250mg $1295 2021-12-16 Buy
DC Chemicals DC23376 KDM5-C70 >98% 1596348-32-1 250mg $1300 2021-12-16 Buy
DC Chemicals DC23376 KDM5-C70 >98% 1596348-32-1 1g $2600 2021-12-16 Buy
Product number Packaging Price Buy
CS-0077883 25mg $175 Buy
CS-0077883 100mg $645 Buy
CS-0077883 250mg $1295 Buy
DC23376 250mg $1300 Buy
DC23376 1g $2600 Buy

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Chemical Properties,Uses,Production

Uses

KDOAM 21 is an inhibitor to KDM5A (Lysine Demethylase 5A) which is a protein coding gene.

Biological Activity

KDM5-C70 (KDOAM-21) corresponds to the ethyl ester precursor of a selective αKG-competitive KDM5 histone demethylase inhibitor KDM5-C49 (KDOAM-21; KDM5A/B/C/D Ki = 2/1/6.1/3.4 nM vs. KDM4C/6B/3A/2A Ki = 0.51/4.55/2.59/4.4 μM; KDM5A/B/C/D IC50 = 1.1/0.8/3.2/2.7 μM by FDH assay with [αKG] = 1 mM & [E]/[S] = 0.5/15 μM; KDM5A/B/C IC50 = 25/30/59 nM by alphaLISA with [αKG] = 25 μM & [E]/[S] = 10/100 nM). KDM5-C70 treatment selectively upregulates cellular histone H3 trimethylation on Lys4 (H3K4me3), but not on Lys9/7/36 (5 μM, 3d), and inhibits KDM5-dependent cancer growth (by 85%/MCF7/11d, 97%/BT474/24d, and 70%/ZR-75-1/24d; 5 μM).

IC 50

KDM5

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Suppliers

Global( 39)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8615965530500 nickzhang@hangyubiotech.com China 8614 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		+8613382787392 sales@aeechem.com China 10000 58
Wuhan TCASChem Technology Co., Ltd. 027-86697669 13986148687 sales@tcaschem.com China 3989 55
Guangzhou Zhiya Chemdrugs Co.,Ltd 18122150900 sculk28@163.com China 646 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 86249 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 7999 62
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Aladdin Scientific 		58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		58
Wuhan TCASChem Technology Co., Ltd. 55
Guangzhou Zhiya Chemdrugs Co.,Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62

View Lastest Price from ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KDM5-C70 pictures 2026-04-22 KDM5-C70
1596348-32-1
 US $56.00-143.00 / mg 99.86% 10g TargetMol Chemicals Inc.
  • KDM5-C70 pictures
  • KDM5-C70
    1596348-32-1
  • US $56.00-143.00 / mg
  • 99.86%
  • TargetMol Chemicals Inc.

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate Spectrum

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate(1596348-32-1)1HNMR

1596348-32-1(ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate)Related Search:

ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-(((2-methoxyethyl)(methyl)amino)methyl)-5-(4-(3-methoxyureido)phenyl)thiophene-3-carboxylate ethyl 5-(4-aMinophenyl)-2-(ethoxycarbonyl)-4-(((2-Methoxyethyl)(Methyl)aMino)Methyl)thiophene-3-carboxylate
159142 ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate KDM5 inhibitor C70 KDOAM 21 KDM5-C49,Histone Demethylase,JARID1,retinoblastoma,inhibit,KDM5 C70,KDM5-C70,KDM-5-C70,phosphorylation,KDM5C70,KDM5,Inhibitor,H3K4me3,antiproliferative 4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, ethyl ester KDM5-C70(KDM5inhibitorC70) KDOAM-21 (KDM5-C70) KDM5-C70, 10 mM in DMSO 1596348-32-1