PXGPLTODNUVGFL-SGSFECARSA-N
- CAS No.
- 1240398-18-8
- Chemical Name:
- PXGPLTODNUVGFL-SGSFECARSA-N
- Synonyms
- 11β-Prostaglandin F2α-d4;PXGPLTODNUVGFL-SGSFECARSA-N;11.beta.-Prostaglandin F2.alpha.-d4;9α,11β,15S-trihydroxy-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4acid
- CBNumber:
- CB53390862
- Molecular Formula:
- C20H34O5
- Molecular Weight:
- 354.49
- MDL Number:
- MOL File:
- 1240398-18-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| NFPA 704 |
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PXGPLTODNUVGFL-SGSFECARSA-N price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10008989 | 11β-Prostaglandin F2α-d4 ≥99%deuteratedforms(d1- |
1240398-18-8 | 50μg | $94 | 2026-04-30 | Buy |
| Cayman Chemical | 10008989 | 11β-Prostaglandin F2α-d4 ≥99%deuteratedforms(d1- |
1240398-18-8 | 100μg | $174 | 2026-04-30 | Buy |
| Cayman Chemical | 10008989 | 11β-Prostaglandin F2α-d4 ≥99%deuteratedforms(d1- |
1240398-18-8 | 500μg | $412 | 2026-04-30 | Buy |
| Biosynth | QZB39818 | 11β-Prostaglandin f2α-d4 | 1240398-18-8 | 1mg | $2816.66 | 2026-06-04 | Buy |
PXGPLTODNUVGFL-SGSFECARSA-N Chemical Properties, Uses, Production
Biological Activity
11β-Prostaglandin F2α-d4 (11β-PGF2α-d4) is intended for use as an internal standard for the quantification of 11β-PGF2α by GC- or LC-MS. 11β-PGF2α is the primary metabolite of PGD2 .1 It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase in the liver or lung.2 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 μM.1 It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 μM.3 11β-PGF2α (0.1 and 1 μM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 μM.4
References
1.Giles, H., Bolofo, M.L., Lydford, S.J., et al.A comparative study of the prostanoid receptor profile of 9α 11 β-prostaglandin F2 and prostaglandin D2Br. J. Pharmacol.104(2)541-549(1991) 2.Watanabe, K.Prostaglandin F synthaseProstaglandins Other Lipid Mediat.68-69401-407(2002) 3.Coleman, R.A., and Sheldrick, R.L.G.Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptorsBr. J. Pharmacol.96(3)688-692(1989) 4.Yoda, T., Kikuchi, K., Miki, Y., et al.11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancerMol. Cell. Endocrinol.413236-247(2015)
PXGPLTODNUVGFL-SGSFECARSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
PXGPLTODNUVGFL-SGSFECARSA-N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4721 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| CHINA ISOTOPE CO., LIMITED | 58 |
