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TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE structure

CAS No.: 158984-83-9

Chemical Name:: TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

Synonyms: RMA-13;N-BOC-6-HYDROXY-3,4-DIHYDRO-ISOQUINOLINE;2-Boc-1,2,3,4-tetrahydroisoquinolin-6-ol;2-N-Boc-6-Hydroxy-3,4-dihydroisoquinoline;6-hydroxy-2-N-Boc-3,4-dihydroisoquinoline;5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate;tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylat;TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;tert-Butyl 6-hydroxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate;tert-butyl 6-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

CBNumber:: CB5342664

Molecular Formula:: C14H19NO3

Molecular Weight:: 249.31

MDL Number:: MFCD08275034

MOL File:: 158984-83-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:44

Product description	Number	Pack Size	Price
tert-Butyl6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate	B693960	500mg	$140
tert-Butyl6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate	7989AA	250mg	$145
tert-Butyl6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate	7989AA	1g	$168
tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate	4H56-1-384	1g	$236
tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 97%	P000056186	5g	$341
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TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Properties

Melting point	110-111.5 °C
Boiling point	391.4±42.0 °C(Predicted)
Density	1.170±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	9.79±0.20(Predicted)
Appearance	White to light brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HazardClass	IRRITANT
HS Code	2933491090

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B693960	tert-Butyl6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate	158984-83-9	500mg	$140	2021-12-16	Buy
AK Scientific	7989AA	tert-Butyl6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate	158984-83-9	250mg	$145	2021-12-16	Buy
AK Scientific	7989AA	tert-Butyl6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate	158984-83-9	1g	$168	2021-12-16	Buy
SynQuest Laboratories	4H56-1-384	tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate	158984-83-9	1g	$236	2021-12-16	Buy
Ark Pharm	P000056186	tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 97%	158984-83-9	5g	$341	2021-12-16	Buy

Product number	Packaging	Price	Buy
B693960	500mg	$140	Buy
7989AA	250mg	$145	Buy
7989AA	1g	$168	Buy
4H56-1-384	1g	$236	Buy
P000056186	5g	$341	Buy

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Chemical Properties,Uses,Production

Uses

tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate is a chemical reagent used in the synthesis of androgen receptor modulators.

Synthesis

24424-99-5

59839-23-5

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

158984-83-9

The general procedure for the synthesis of N-BOC-6-hydroxy-3,4-dihydroisoquinolines from di-tert-butyl dicarbonate and 1,2,3,4-tetrahydroisoquinolin-6-ol hydrobromide was as follows: 1,2,3,4-tetrahydroisoquinolin-6-ol hydrobromide (1.54 g, 6.4 mmol) was suspended in water, and a solution of tetrahydrofuran was slowly added dropwise with triethylamine (1.42 mg, 14.0 mmol ) and di-tert-butyl dicarbonate (1.67 mg, 7.6 mmol) to a tetrahydrofuran solution. The reaction mixture was stirred at room temperature overnight. Subsequently, the reaction solution was concentrated and the residue was dissolved in ethyl acetate, washed with water and dried over anhydrous sodium sulfate. After removal of the solvent by evaporation under reduced pressure, the residue was purified by fast column chromatography (ethyl acetate: hexane = 1:5) to afford N-BOC-6-hydroxy-3,4-dihydroisoquinoline as a viscous yellow oil (1.58 g, 99%). The product was characterized by 1H NMR (300 MHz, CDCl3) and ESI-MS: 1H NMR (300 MHz, CDCl3) δ 6.92 (s, 1H), 6.71 (s, 1H), 6.70 (s, 1H), 6.31 (s, 1H), 4.48 (s, 2H), 3.60 (t, J=5.7Hz, 2H), 2.75 (t, J=5.7Hz, 2H), 1.49 (s, 9H); ESI-MS m/z 248 (MH-).

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 4, p. 789 - 801
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 10, p. 3586 - 3604
[3] Patent: WO2010/127212, 2010, A1. Location in patent: Page/Page column 31
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 8, p. 3414 - 3418
[5] Synthetic Communications, 1995, vol. 25, # 20, p. 3255 - 3261

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE synthesis

Synthesis of TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE from Di-tert-butyl dicarbonate

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL HBR 6-METHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 1,2,3,4-Tetrahydro-isoquinolin-6-ol Hydrochloride 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL

Piperidine Di-tert-butyl dicarbonate Triethylamine Tetrahydrofuran Water

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Preparation Products

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Suppliers

Global( 115)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Chembon Pharmaceutical Co., Ltd.	55
career henan chemical co	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Labnetwork lnc.	58

View Lastest Price from TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2020-03-06	TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 158984-83-9	US $1.00 / KG	1KG	99%	200kgs	Career Henan Chemical Co
2020-03-06	TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 158984-83-9	US $1.00 / KG	1KG	99%	200kgs	Career Henan Chemical Co
2019-07-06	TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 158984-83-9	US $1.00 / kg	1kg	99%	Customized	Career Henan Chemical Co

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
158984-83-9
US $1.00 / KG
99%
Career Henan Chemical Co

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
158984-83-9
US $1.00 / KG
99%
Career Henan Chemical Co

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
158984-83-9
US $1.00 / kg
99%
Career Henan Chemical Co

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Spectrum

TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE(158984-83-9)¹HNMR

158984-83-9(TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE)Related Search:

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TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE 6-HYDROXY-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate N-BOC-6-HYDROXY-3,4-DIHYDRO-ISOQUINOLINE 6-hydroxy-2-N-Boc-3,4-dihydroisoquinoline tert-Butyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate tert-butyl 6-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 95+% tert-Butyl 6-hydroxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate 2-N-Boc-6-Hydroxy-3,4-dihydroisoquinoline TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE-10 3,4-Dihydro-6-hydroxy-2(1H)-isoquinolinecarboxylic acid tert-butyl ester 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-hydroxy-, 1,1-dimethylethyl ester TERT-BUTYL 6-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLA... 2-Boc-1,2,3,4-tetrahydroisoquinolin-6-ol RMA-13 tert-Butyl 6-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylat 158984-83-9