Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>5,7-Difluoroindole

5,7-Difluoroindole

5,7-Difluoroindole Structure
5,7-Difluoroindole structure
CAS No.
301856-25-7
Chemical Name:
5,7-Difluoroindole
Synonyms
SW-101;SWF-101;5,7-difluoroinde;5,8-Difluoroindole;5,7-DIFLUOROINDOLE;5,7-Difluoro-1H-Indole;1H-Indole, 5,7-difluoro-;1H-Indole,5,7-difluoro-(9CI)
CBNumber:
CB5344431
Molecular Formula:
C8H5F2N
Molecular Weight:
153.13
MDL Number:
MFCD01075215
MOL File:
301856-25-7.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:44
Product description Number Pack Size Price
5,7-Difluoroindole D452068 50mg $45
5,7-Difluoro-1H-indole PC7807 250mg $79
5,7-Difluoro-1H-indole 3H31-3-Q1 250mg $87
5,7-Difluoro-1H-indole 99.35% CS-W022280 250mg $91
5,7-Difluoro-1H-indole PC7807 1g $198
More product size
Request For Quotation

5,7-Difluoroindole Properties

Boiling point 253.2±20.0 °C(Predicted)
Density 1.388±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form liquid
pka 14.71±0.30(Predicted)
color Light yellow
InChI InChI=1S/C8H5F2N/c9-6-3-5-1-2-11-8(5)7(10)4-6/h1-4,11H
InChIKey WZPOGQRJXZGSMH-UHFFFAOYSA-N
SMILES N1C2=C(C=C(F)C=C2F)C=C1
CAS DataBase Reference 301856-25-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Hazard Note  Irritant
HS Code  2933998090

5,7-Difluoroindole price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D452068 5,7-Difluoroindole 301856-25-7 50mg $45 2021-12-16 Buy
Apolloscientific PC7807 5,7-Difluoro-1H-indole 301856-25-7 250mg $79 2021-12-16 Buy
SynQuest Laboratories 3H31-3-Q1 5,7-Difluoro-1H-indole 301856-25-7 250mg $87 2021-12-16 Buy
ChemScene CS-W022280 5,7-Difluoro-1H-indole 99.35% 301856-25-7 250mg $91 2021-12-16 Buy
Apolloscientific PC7807 5,7-Difluoro-1H-indole 301856-25-7 1g $198 2021-12-16 Buy
Product number Packaging Price Buy
D452068 50mg $45 Buy
PC7807 250mg $79 Buy
3H31-3-Q1 250mg $87 Buy
CS-W022280 250mg $91 Buy
PC7807 1g $198 Buy

5,7-Difluoroindole Chemical Properties,Uses,Production

Synthesis

Carbamic acid, [2,4-difluoro-6-[(trimethylsilyl)ethynyl]phenyl]-, ethyl ester (9CI)

500139-00-4

5,7-Difluoroindole

301856-25-7

Example 4: Synthesis of the intermediate 5,7-difluoro-1H-indole To a solution of ethanol (35 mL) containing NaOEt (1.83 g, 26.9 mmol), a solution of ethyl (2,4-difluoro-6-trimethylsilylethynylphenyl)carbamate (2 g, 6.73 mmol) in ethanol (10 mL) was slowly added. The reaction mixture was stirred at room temperature for 1 h (monitored by TLC until the disappearance of the feedstock), followed by refluxing for 1 h. The reaction was completed by cooling to room temperature. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated under vacuum. The residue was dissolved in ether (50 mL) and washed sequentially with dilute hydrochloric acid (3 x 25 mL) and saturated saline (3 x 25 mL). The organic layer was dried with anhydrous Na2SO4, filtered and concentrated in vacuum. Purification by silica gel fast column chromatography (eluent ratio 1:4 ethyl acetate:hexane) gave 770 mg of the title compound in 75% yield.

References

[1] Patent: WO2005/12291, 2005, A1. Location in patent: Page/Page column 63

5,7-Difluoroindole Preparation Products And Raw materials

Raw materials

Carbamic acid, [2,4-difluoro-6-[(trimethylsilyl)ethynyl]phenyl]-, ethyl ester (9CI) Sodium ethoxide Ethanol

Preparation Products

5,7-Difluoroindole Suppliers

Global( 129)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 9546 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30227 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14304 58
KARMEL TECHNOLOGY (HK) CO.,LIMITED 		+8618795957998 karmelhk@126.com CHINA 2886 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Fluoropharm Co., Ltd. 		60
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
Career Henan Chemica Co 		58
Win-Win chemical CO., Limited 		58
KARMEL TECHNOLOGY (HK) CO.,LIMITED 		58

5,7-Difluoroindole Spectrum

5,7-Difluoroindole(301856-25-7)1HNMR

301856-25-7(5,7-Difluoroindole)Related Search:

Indole-3-butyric acid Indoline Indometacin Indole-3-acetic acid 5-FLUORO-4-IODO-1H-PYRROLO[2,3-B]PYRIDINE
3,6-Dichloro-4-methylpyridazine Methyl 7-azaindole-6-carboxylate methyl 6‐bromo‐2‐oxo‐2,3‐dihydro‐1h‐indole‐4‐carboxylate 4-AMINO-1-[(2,4-DIMETHOXYPHENYL)METHYL]PYRROLIDIN-2-ONE 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID
6-Chloro-5-fluoro-7-azaindole 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]- 7-Bromopyrido[3,2-d]pyrimidin-4(3H)-one
[1-(trifluoromethyl)cyclopropyl]methanamine hydrochloride 5,6-dichloro-1H-Indole-3-carboxaldehyde 2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

1of4

5,7-DIFLUOROINDOLE 5,7-difluoroinde 1H-Indole,5,7-difluoro-(9CI) 5,7-Difluoro-1H-Indole 1H-Indole, 5,7-difluoro- SWF-101 SW-101 5,8-Difluoroindole 301856-25-7 30185-25-7 HALIDE INDOLE Indoles and derivatives pharmacetical Indoles