1-N-CBZ-3-PIPERIDONE
- CAS No.
- 61995-20-8
- Chemical Name:
- 1-N-CBZ-3-PIPERIDONE
- Synonyms
- BENZYL 3-OXOPIPERIDINE-1-CARBOXYLATE;1-CBZ-3-PIPERIDONE;N-Cbz-3-Piperidone;1-CBZ-3-PIPERIDINONE;1-N-CBZ-3-PIPERIDONE;1-Benzyloxycarbonyl-3-piperidone, 97+%;3-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;1-Piperidinecarboxylic acid, 3-oxo-, phenylmethyl ester
- CBNumber:
- CB5346172
- Molecular Formula:
- C13H15NO3
- Molecular Weight:
- 233.26
- MDL Number:
- MFCD03001723
- MOL File:
- 61995-20-8.mol
| Boiling point | 384.1±42.0 °C(Predicted) |
|---|---|
| Density | 1.212 |
| storage temp. | 2-8°C |
| pka | -1.76±0.20(Predicted) |
| form | Liquid |
| Appearance | Light yellow to yellow Liquid |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C13H15NO3/c15-12-7-4-8-14(9-12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6H,4,7-10H2 |
| InChIKey | ALXLNFWWLXCXSK-UHFFFAOYSA-N |
| SMILES | N1(C(OCC2=CC=CC=C2)=O)CCCC(=O)C1 |
| CAS DataBase Reference | 61995-20-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 23-26-37-60 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
1-N-CBZ-3-PIPERIDONE price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | H64471 | 1-Benzyloxycarbonyl-3-piperidone, 97+% | 61995-20-8 | 1g | $50.65 | 2024-03-01 | Buy |
| Alfa Aesar | H64471 | 1-Benzyloxycarbonyl-3-piperidone, 97+% | 61995-20-8 | 5g | $184.65 | 2024-03-01 | Buy |
| Alfa Aesar | H64471 | 1-Benzyloxycarbonyl-3-piperidone, 97+% | 61995-20-8 | 25g | $799.65 | 2024-03-01 | Buy |
| TRC | B194173 | Benzyl3-Oxopiperidine-1-carboxylate | 61995-20-8 | 1g | $75 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-LB | 1-Cbz-3-piperidone | 61995-20-8 | 5G | $75 | 2021-12-16 | Buy |
1-N-CBZ-3-PIPERIDONE Chemical Properties,Uses,Production
Uses
1-Benzyloxycarbonyl-3-piperidone finds its application in the synthesis and pharmacological evaluation of some 6-substituted 7-methyl-1,4-dioxa-7-azaspiro[4.5]decanes as potential dopamine agonists.
Synthesis
95798-22-4
61995-20-8
General procedure for the synthesis of 1-N-Cbz-3-piperidone from N-Benzyloxycarbonyl-3-hydroxypiperidine: N-Benzyloxycarbonyl-3-hydroxypiperidine (16.50 g, 70 mmol) was dissolved in dichloromethane (90 mL), stirred and cooled to 0 °C. Subsequently, N,N-diisopropylethylamine (DIPEA, 45.30 g, 0.35 mol) was added to the reaction system. A solution of dimethyl sulfoxide (DMSO, 100 mL) of pyridine trioxide (25.70 g, 0.16 mol) was slowly added dropwise at 0 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0°C for 2 hours. After completion of the reaction, the mixture was poured into 4 M hydrochloric acid and extracted with dichloromethane (100 mL x 3). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1/100 to 1/6, v/v) to afford 1-N-Cbz-3-piperidone (14.90 g, 90% yield) as an off-white solid. The structure of the product was confirmed by LC-MS, LC-MS: [M + H]+ = 234.
References
[1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 6, p. 1843 - 1845
[2] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 45
[3] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 6, p. 811 - 814
[4] Patent: EP1757582, 2007, A1. Location in patent: Page/Page column 35-36
[5] Patent: WO2014/68527, 2014, A1. Location in patent: Page/Page column 75; 156; 157
1-N-CBZ-3-PIPERIDONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 1-N-CBZ-3-PIPERIDONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-N-CBZ-3-PIPERIDONE
61995-20-8
|
US $1.00 / KG | 1KG | 96% | 500kg | Career Henan Chemical Co |
-
- 1-N-CBZ-3-PIPERIDONE
61995-20-8
- US $1.00 / KG
- 96%
- Career Henan Chemical Co