ChemicalBook >> CAS DataBase List >>1-N-CBZ-3-PIPERIDONE

1-N-CBZ-3-PIPERIDONE

CAS No.
61995-20-8
Chemical Name:
1-N-CBZ-3-PIPERIDONE
Synonyms
BENZYL 3-OXOPIPERIDINE-1-CARBOXYLATE;1-CBZ-3-PIPERIDONE;N-Cbz-3-Piperidone;1-CBZ-3-PIPERIDINONE;1-N-CBZ-3-PIPERIDONE;1-Benzyloxycarbonyl-3-piperidone, 97+%;3-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;1-Piperidinecarboxylic acid, 3-oxo-, phenylmethyl ester
CBNumber:
CB5346172
Molecular Formula:
C13H15NO3
Molecular Weight:
233.26
MDL Number:
MFCD03001723
MOL File:
61995-20-8.mol
Last updated:2025-07-24 18:13:49

1-N-CBZ-3-PIPERIDONE Properties

Boiling point 384.1±42.0 °C(Predicted)
Density 1.212
storage temp. 2-8°C
pka -1.76±0.20(Predicted)
form Liquid
Appearance Light yellow to yellow Liquid
Water Solubility Slightly soluble in water.
InChI InChI=1S/C13H15NO3/c15-12-7-4-8-14(9-12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6H,4,7-10H2
InChIKey ALXLNFWWLXCXSK-UHFFFAOYSA-N
SMILES N1(C(OCC2=CC=CC=C2)=O)CCCC(=O)C1
CAS DataBase Reference 61995-20-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  23-26-37-60
HS Code  29333990
NFPA 704
1
2 0

1-N-CBZ-3-PIPERIDONE price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar H64471 1-Benzyloxycarbonyl-3-piperidone, 97+% 61995-20-8 1g $50.65 2024-03-01 Buy
Alfa Aesar H64471 1-Benzyloxycarbonyl-3-piperidone, 97+% 61995-20-8 5g $184.65 2024-03-01 Buy
Alfa Aesar H64471 1-Benzyloxycarbonyl-3-piperidone, 97+% 61995-20-8 25g $799.65 2024-03-01 Buy
TRC B194173 Benzyl3-Oxopiperidine-1-carboxylate 61995-20-8 1g $75 2021-12-16 Buy
SynQuest Laboratories 4H56-1-LB 1-Cbz-3-piperidone 61995-20-8 5G $75 2021-12-16 Buy
Product number Packaging Price Buy
H64471 1g $50.65 Buy
H64471 5g $184.65 Buy
H64471 25g $799.65 Buy
B194173 1g $75 Buy
4H56-1-LB 5G $75 Buy

1-N-CBZ-3-PIPERIDONE Chemical Properties,Uses,Production

Uses

1-Benzyloxycarbonyl-3-piperidone finds its application in the synthesis and pharmacological evaluation of some 6-substituted 7-methyl-1,4-dioxa-7-azaspiro[4.5]decanes as potential dopamine agonists.

Synthesis

1-N-CBZ-3-HYDROXY-PIPERIDINE

95798-22-4

1-N-CBZ-3-PIPERIDONE

61995-20-8

General procedure for the synthesis of 1-N-Cbz-3-piperidone from N-Benzyloxycarbonyl-3-hydroxypiperidine: N-Benzyloxycarbonyl-3-hydroxypiperidine (16.50 g, 70 mmol) was dissolved in dichloromethane (90 mL), stirred and cooled to 0 °C. Subsequently, N,N-diisopropylethylamine (DIPEA, 45.30 g, 0.35 mol) was added to the reaction system. A solution of dimethyl sulfoxide (DMSO, 100 mL) of pyridine trioxide (25.70 g, 0.16 mol) was slowly added dropwise at 0 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0°C for 2 hours. After completion of the reaction, the mixture was poured into 4 M hydrochloric acid and extracted with dichloromethane (100 mL x 3). The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1/100 to 1/6, v/v) to afford 1-N-Cbz-3-piperidone (14.90 g, 90% yield) as an off-white solid. The structure of the product was confirmed by LC-MS, LC-MS: [M + H]+ = 234.

References

[1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 6, p. 1843 - 1845
[2] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 45
[3] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 6, p. 811 - 814
[4] Patent: EP1757582, 2007, A1. Location in patent: Page/Page column 35-36
[5] Patent: WO2014/68527, 2014, A1. Location in patent: Page/Page column 75; 156; 157

Global( 168)Suppliers
Supplier Tel Email Country ProdList Advantage
Chembon Pharmaceutical Co., Ltd.
+86-28-8425-2981 CHINA 722 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Accela ChemBio Inc.
+1-858-6993322 info@accelachem.com United States 21193 58
Changzhou Ditong Chemical Co.,Ltd
+86-0519-88299272 info@edengenechem.com China 2176 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd
027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49733 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58

View Lastest Price from 1-N-CBZ-3-PIPERIDONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-N-CBZ-3-PIPERIDONE pictures 2019-07-06 1-N-CBZ-3-PIPERIDONE
61995-20-8
US $1.00 / KG 1KG 96% 500kg Career Henan Chemical Co

1-N-CBZ-3-PIPERIDONE Spectrum

61995-20-8(1-N-CBZ-3-PIPERIDONE)Related Search:

1-N-CBZ-3-PIPERIDONE 1-CBZ-3-PIPERIDINONE 1-CBZ-3-PIPERIDONE BENZYL 3-OXOPIPERIDINE-1-CARBOXYLATE 3-OXO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER N-Cbz-3-Piperidone 1-Benzyloxycarbonyl-3-piperidone, 97+% 1-Piperidinecarboxylic acid, 3-oxo-, phenylmethyl ester 61995-20-8 61955-20-8 pharmacetical Piperidine