3-Chlorothiophene-2-carboxylic acid
- CAS No.
- 59337-89-2
- Chemical Name:
- 3-Chlorothiophene-2-carboxylic acid
- Synonyms
- EA160;AKOS 93295;BUTTPARK 29\06-43;RARECHEM AL BE 1228;TIMTEC-BB SBB003936;3-Chlorothiophene-2-c;Rivaroxaban Impurity RC-28;3-CHLOROTHIOPHENE-2-CARBOXYLIC ACID;2-Thiophenecarboxylicacid, 3-chloro-;3-Chlorothiophene-2-carboxylicacid98%
- CBNumber:
- CB5360611
- Molecular Formula:
- C5H3ClO2S
- Molecular Weight:
- 162.59
- MDL Number:
- MFCD00043888
- MOL File:
- 59337-89-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Chlorothiophene-2-carboxylic acid 97% | 586994 | 5g | $153 |
| 3-Chlorothiophene-2-carboxylic acid | C428155 | 500mg | $60 |
| 3-Chlorothiophene-2-carboxylic acid | C428155 | 1g | $70 |
| 3-Chlorothiophene-2-carboxylic acid 98% | P000265776 | 10g | $46 |
| 3-Chlorothiophene-2-carboxylic acid 98% | OR2721 | 1g | $15 |
| More product size | |||
| Melting point | 186-190 °C (lit.) |
|---|---|
| Boiling point | 291.7±20.0 °C(Predicted) |
| Density | 1.466 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| pka | 3.09±0.10(Predicted) |
| form | solid |
| color | White to Off-White |
| BRN | 121052 |
| InChI | InChI=1S/C5H3ClO2S/c6-3-1-2-9-4(3)5(7)8/h1-2H,(H,7,8) |
| InChIKey | BXEAAHIHFFIMIE-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)SC=CC=1Cl |
| CAS DataBase Reference | 59337-89-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Chlorothiophene-2-carboxylic acid price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 586994 | 3-Chlorothiophene-2-carboxylic acid 97% | 59337-89-2 | 5g | $153 | 2025-07-31 | Buy |
| TRC | C428155 | 3-Chlorothiophene-2-carboxylic acid | 59337-89-2 | 500mg | $60 | 2021-12-16 | Buy |
| TRC | C428155 | 3-Chlorothiophene-2-carboxylic acid | 59337-89-2 | 1g | $70 | 2021-12-16 | Buy |
| Ark Pharm | P000265776 | 3-Chlorothiophene-2-carboxylic acid 98% | 59337-89-2 | 10g | $46 | 2021-12-16 | Buy |
| Apolloscientific | OR2721 | 3-Chlorothiophene-2-carboxylic acid 98% | 59337-89-2 | 1g | $15 | 2021-12-16 | Buy |
3-Chlorothiophene-2-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Chlorothiophene-2-carboxylic acid may be used in the synthesis of 3-chloro-N-[(4-chlorophenyl)(methyl)carbamothioyl]thiophene-2-carboxamide.
Synthesis
88105-17-3
59337-89-2
GENERAL STEPS: Methyl 3-chlorothiophene-2-carboxylate (50 g, 0.28 mol) was dissolved in methanol (100 mL), aqueous sodium hydroxide solution (2M, 400 mL) was added slowly, and the reaction temperature was maintained at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. After removal of methanol by distillation under reduced pressure, the aqueous phase was washed with ether and subsequently acidified with 2N hydrochloric acid to pH < 3. The precipitated white solid was collected by filtration and dried under vacuum to give 3-chlorothiophene-2-carboxylic acid (45 g, 98% yield). Mass spectrometry (MS) analysis showed a molecular ion peak (M+H+) of 163.
References
[1] Heterocycles, 1985, vol. 23, # 6, p. 1431 - 1435
[2] Patent: WO2012/139425, 2012, A1. Location in patent: Page/Page column 119
[3] Heterocycles, 2007, vol. 71, # 1, p. 87 - 104
[4] Patent: WO2013/28670, 2013, A1. Location in patent: Page/Page column 96
[5] Patent: US9181236, 2015, B2. Location in patent: Page/Page column 107
3-Chlorothiophene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20128 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from 3-Chlorothiophene-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-30 | 3-Chlorothiophene-2-carboxylic acid
59337-89-2
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-11-18 | 3-Chlorothiophene-2-carboxylic acid
59337-89-2
|
US $1.10 / g | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-09-25 | 3-Chlorothiophene-2-carboxylic acid
59337-89-2
|
US $30.00-0.90 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 3-Chlorothiophene-2-carboxylic acid
59337-89-2
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Chlorothiophene-2-carboxylic acid
59337-89-2
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 3-Chlorothiophene-2-carboxylic acid
59337-89-2
- US $30.00-0.90 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
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