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1-METHYLCYTOSIN

1-METHYLCYTOSIN Structure
1-METHYLCYTOSIN structure
CAS No.
1122-47-0
Chemical Name:
1-METHYLCYTOSIN
Synonyms
NSC 47693;1-METHYLCYTOSIN;1-METHYLCYTOSINE;N1-Methylcytosine;RARECHEM AQ NN 0292;4-amino-1-methylpyrimidin-2-one;1-Methylcytosine, 10 mM in DMSO;4-amino-1-methyl-pyrimidin-2-one;4-azanyl-1-methyl-pyrimidin-2-one;4-Amino-1-methyl-2(1H)-pyrimidinone
CBNumber:
CB5360974
Molecular Formula:
C5H7N3O
Molecular Weight:
125.13
MDL Number:
MFCD00038058
MOL File:
1122-47-0.mol
MSDS File:
SDS
Last updated:2026-01-04 17:25:11
Product description Number Pack Size Price
4-Amino-1-methylpyrimidin-2(1H)-one A898218 50mg $120
1-Methylcytosine CS-W006395 1g $442
4-Amino-1-methylpyrimidin-2(1H)-one 118359 1g $649
4-Amino-1-methylpyrimidin-2(1H)-one 2618AL 1g $879
1-METHYLCYTOSIN 95.00% CHM0006848 5G $1152.11
Request For Quotation

1-METHYLCYTOSIN Properties

Melting point 300-303℃
Boiling point 242℃
Density 1.34
Flash point 100℃
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Methanol (Slightly), Water (Slightly)
form Solid
pka 4.53±0.10(Predicted)
color White to Off-White
FDA UNII 1J54NE82RV

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  2933399990

1-METHYLCYTOSIN price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A898218 4-Amino-1-methylpyrimidin-2(1H)-one 1122-47-0 50mg $120 2021-12-16 Buy
ChemScene CS-W006395 1-Methylcytosine 1122-47-0 1g $442 2021-12-16 Buy
Matrix Scientific 118359 4-Amino-1-methylpyrimidin-2(1H)-one 1122-47-0 1g $649 2021-12-16 Buy
AK Scientific 2618AL 4-Amino-1-methylpyrimidin-2(1H)-one 1122-47-0 1g $879 2021-12-16 Buy
American Custom Chemicals Corporation CHM0006848 1-METHYLCYTOSIN 95.00% 1122-47-0 5G $1152.11 2021-12-16 Buy
Product number Packaging Price Buy
A898218 50mg $120 Buy
CS-W006395 1g $442 Buy
118359 1g $649 Buy
2618AL 1g $879 Buy
CHM0006848 5G $1152.11 Buy

1-METHYLCYTOSIN Chemical Properties,Uses,Production

Uses

1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine[1][2].

Definition

ChEBI: A pyrimidone that is cytosine in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group.

Synthesis

Methanimidamide, N'-(1,2-dihydro-1-methyl-2-oxo-4-pyrimidinyl)-N,N-dimethyl-

77738-01-3

1-METHYLCYTOSIN

1122-47-0

4-N-(N,N-dimethylaminomethylene)-1-methylcytosine (1.0 g, 5.5 mmol) was added to a 100 mL round bottom flask equipped with a magnetic stirrer along with an ethanol solution (50 mL) containing 30% methylamine. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the precipitated white solid was collected by filtration and purified by recrystallization using ethanol-water solvent mixture. 4-Amino-1-methylpyrimidin-2(1H)-one was finally obtained as a white solid (0.61 g, 88% yield). The structure of the product was analyzed by 1H NMR (400 MHz, DMSO-d6): δ3.31 (s, 3H), 5.59 (d, 1H), 6.91 (br, 2H), 7.54 (d, 1H); 13C NMR (100 MHz, DMSO-d6): δ6.6, 92.9, 146.6, 156.3, 166.1; mass spectrometry (ES+) ) analysis: calculated value C5H7N3O+ (M+H+) 126.0662, measured value 126.0804 confirmed.

References

[1] Kistenmacher, T. J.; Rossi, M. (1977-12-15). "1-Methylcytosine: a refinement". Acta Crystallographica (1977) Section B. 33 (12): 3962–3965.
[2] Hoshika S, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science. 2019 Feb 22;363(6429):884-887. DOI:10.1126/science.aat0971

1-METHYLCYTOSIN synthesis

77738-01-3
1122-47-0
Synthesis of 1-METHYLCYTOSIN from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1-METHYLCYTOSIN Preparation Products And Raw materials

Raw materials

2(1H)-Pyrimidinone, 4-(dimethylamino)-1-methyl- 1-methyl-4-methylamino-pyrimidin-2-one 4-methoxy-1-methyl-1,2-dihydropyrimidin-2-one 1-Methyl-4-thioxo-3,4-dihydropyrimidine-2(1H)-one 1,3-Dimethyluracil
1-METHYLURACIL DIPHENYL(METHYL)SULFONIUM TETRAFLUOROBORATE Iodomethane Dimethyl carbonate Cytosine

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Preparation Products

3-Methylcytosine

1-METHYLCYTOSIN Suppliers

Global( 71)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569266 +86-17392581500 1015@dideu.com China 3987 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
NewCan Biotech Limited 		+86-0571-86912261 +8613735419629 sales@newcanbio.com China 9985 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39042 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19964 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
NewCan Biotech Limited 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
Amadis Chemical Company Limited 		58

View Lastest Price from 1-METHYLCYTOSIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Methylcytosine pictures 2026-01-04 1-Methylcytosine
1122-47-0
 US $29.00 / mg 99.88% 10g TargetMol Chemicals Inc.
1-Methylcytosine pictures 2026-01-04 1-Methylcytosine
1122-47-0
 US $29.00 / mg 99.88% 10g TargetMol Chemicals Inc.
1-Methylcytosine pictures 2025-05-01 1-Methylcytosine
1122-47-0
 US $29.00 / mg 100% 10g TargetMol Chemicals Inc.

1-METHYLCYTOSIN Spectrum

1-METHYLCYTOSIN(1122-47-0)1HNMR

1122-47-0(1-METHYLCYTOSIN)Related Search:

5-Methyl-2'-deoxycytidine N4-Benzoylcytidine 2'-Deoxycytidine Zalcitabine Cytidine 5’-monophosphate
N-Benzoyl-2'-deoxy-cytidine CYTIDINE 2'-MONOPHOSPHATE 2'-Deoxycytidine-5'-monophosphoric acid Cytidine 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine
2'-Deoxycytidine hydrochloride DMT-dC(bz) Phosphoramidite (+)-3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)cytidine CYTIDINE 3'-MONOPHOSPHATE N4-Acetylcytidine
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2(1H)-Pyrimidinone,4-amino-1-methyl- 1-METHYLCYTOSIN 1-METHYLCYTOSINE NSC 47693 RARECHEM AQ NN 0292 1-Methyl-1,2,3,4-tetrahydro-4-iminopyrimidine-2-one 1-Methyl-4-amino-1,2-dihydropyrimidine-2-one 1-Methyl-4-aminopyrimidine-2(1H)-one 1-Methyl-4-imino-1,2,3,4-tetrahydropyrimidine-2-one 4-Amino-1-methyl-2(1H)-pyrimidinone N1-Methylcytosine 4-amino-1-methyl-pyrimidin-2-one 4-amino-1-methylpyrimidin-2-one 4-azanyl-1-methyl-pyrimidin-2-one 4-aMino-1-MethylpyriMidin-2(1H)-one 4-AMino-1-Methyl-1H-pyriMidin-2-one 3-Oxazolidinecarboxylicacid,2,2-dimethyl-4-(2-oxoethyl)-,1,1-dimethylethylester,(5S)- 1-Methylcytosine, 10 mM in DMSO 1122-47-0