Gimeracil
- CAS No.
- 103766-25-2
- Chemical Name:
- Gimeracil
- Synonyms
- CDHP;CDH3;HJMD;CS-84;Gimost;gimestat;imeraciL;GIMERACIL;Gimeradll;Gemaemine
- CBNumber:
- CB5362004
- Molecular Formula:
- C5H4ClNO2
- Molecular Weight:
- 145.54
- MDL Number:
- MFCD08458352
- MOL File:
- 103766-25-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Gimeracil ≥98% (HPLC) | SML2075 | 5MG | $60.8 |
| Gimeracil ≥98% (HPLC) | SML2075 | 25MG | $149 |
| Gimeracil >98.0%(HPLC)(T) | C2243 | 1g | $80 |
| Gimeracil >98.0%(HPLC)(T) | C2243 | 5g | $266 |
| Gimeracil ≥98% | 16525 | 50mg | $41 |
| More product size | |||
| Melting point | 274 °C |
|---|---|
| Boiling point | 255.1±40.0 °C(Predicted) |
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 5 mg/ml). |
| pka | 4.50±1.00(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9) |
| InChIKey | ZPLQIPFOCGIIHV-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(Cl)C(O)=C1 |
| CAS DataBase Reference | 103766-25-2(CAS DataBase Reference) |
| FDA UNII | UA8SE1325T |
| NCI Drug Dictionary | gimeracil |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Gimeracil price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2075 | Gimeracil ≥98% (HPLC) | 103766-25-2 | 5MG | $60.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2075 | Gimeracil ≥98% (HPLC) | 103766-25-2 | 25MG | $149 | 2026-04-30 | Buy |
| TCI Chemical | C2243 | Gimeracil >98.0%(HPLC)(T) | 103766-25-2 | 1g | $80 | 2026-04-30 | Buy |
| TCI Chemical | C2243 | Gimeracil >98.0%(HPLC)(T) | 103766-25-2 | 5g | $266 | 2026-04-30 | Buy |
| Cayman Chemical | 16525 | Gimeracil ≥98% | 103766-25-2 | 50mg | $41 | 2026-04-30 | Buy |
Gimeracil Chemical Properties,Uses,Production
Description
Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor. DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2 Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3
Chemical Properties
Off-White Solid
Uses
Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.
Uses
Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).
Uses
Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)
Definition
ChEBI: Gimeracil is an organic molecular entity.
Synthesis
103792-80-9
103766-25-2
Compound 6 (8.0 g, 44 mmol) was used as a raw material, which was mixed with acetonitrile (100 mL), acetic acid (3 mL) and sodium iodide (13.2 g, 88 mmol), and the reaction was heated at 60°C for 8 hours. Upon completion of the reaction, the mixture was cooled to room temperature and poured into 10% sodium thiosulfate solution (200 mL) to precipitate a colorless solid. Purification by aqueous recrystallization afforded the target product 5-chloro-4-hydroxypyridin-2(1H)-one (Compound 2) in a yield of 5.6 g in 86%. The product characterization data were as follows: melting point 272-273 °C (literature value 273-274 °C); 1H NMR (400 MHz, DMSO-d6) δ 5.70 (s, 1H), 7.51 (s, 1H), 11.29 (br, 2H); 13C NMR (100 MHz, DMSO-d6) δ 163.5, 163.2, 134.6 , 105.6, 98.7; LRMS (ESI) m/z (%): 146 (100) [M(35Cl)+H]+, 148 (30) [M(37Cl)+H]+; HRMS (ESI) m/z calculated value of C5H535ClNO2: [M+H]+: 146.0003, measured value: 146.0012; C5H537ClNO2: [M+H]+: 147.9975, measured value: 147.9975.
in vivo
Gimeracil (2.5-25 mg/kg, orally) may inhibit the rapid repair of X-ray-induced DNA damage in tumors[3].
| Animal Model: | Nude mice (Lu-99, LC-11, KB/C3 and PAN-4 tumors were xenografted)[3]. |
| Dosage: | 2.5-25 mg/kg. |
| Administration: | Orally. |
| Result: | Exhibited anti-tumor activity. |
References
[1] DIASIO R B. Clinical implications of dihydropyrimidine dehydrogenase inhibition.[C]//13 7 Suppl 3. 1999: 17-21.
[2] MASAO KOBAYAKAWA Yasushi K. Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies.[J]. OncoTargets and therapy, 2011, 4: 193-201. DOI:10.2147/ott.s19059
[3] KOH-ICHI SAKATA. Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination[J]. Cancer Science, 2011, 102 9: 1712-1716. DOI:10.1111/j.1349-7006.2011.02004.x
Gimeracil Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29817 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
View Lastest Price from Gimeracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Gimeracil
103766-25-2
|
US $29.00 / mg | 99.86% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-20 | Gimeracil
103766-25-2
|
US $29.00 / mg | 99.86% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | Gimeracil
103766-25-2
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
