4-Bromo-2-methoxypyridine
- CAS No.
- 100367-39-3
- Chemical Name:
- 4-Bromo-2-methoxypyridine
- Synonyms
- 4-BROMO-2-METHOXYPYRIDINE;2-Methoxy-4-broMoquinoline;Pyridine,4-bromo-2-methoxy-;4-Bromo-2-Methoxypyridine(WX637041);4-Bromo-2-methoxypyridine ISO 9001：2015 REACH
- CBNumber:
- CB5371404
- Molecular Formula:
- C6H6BrNO
- Molecular Weight:
- 188.02
- MDL Number:
- MFCD08277268
- MOL File:
- 100367-39-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-2-methoxypyridine | 069710 | 10.00g | $29 |
| 4-Bromo-2-methoxypyridine | 069710 | 25.00g | $67 |
| 4-Bromo-2-methoxypyridine | 069710 | 100.00g | $206 |
| 4-Bromo-2-methoxypyridine 95% | B3113 | 1g | $12 |
| 4-Bromo-2-methoxypyridine 95% | B3113 | 5g | $21 |
| More product size | |||
| Melting point | 25-26℃ |
|---|---|
| Boiling point | 87℃/15mm |
| Density | 1.530±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 3.76±0.10(Predicted) |
| form | Low Melting Solid |
| color | Off-white to pale yellow |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C6H6BrNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3 |
| InChIKey | YFTGMMXMLPTTAY-UHFFFAOYSA-N |
| SMILES | C1(OC)=NC=CC(Br)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
4-Bromo-2-methoxypyridine price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 069710 | 4-Bromo-2-methoxypyridine | 100367-39-3 | 10.00g | $29 | 2026-05-18 | Buy |
| Matrix Scientific | 069710 | 4-Bromo-2-methoxypyridine | 100367-39-3 | 25.00g | $67 | 2026-05-18 | Buy |
| Matrix Scientific | 069710 | 4-Bromo-2-methoxypyridine | 100367-39-3 | 100.00g | $206 | 2026-05-18 | Buy |
| Synthonix | B3113 | 4-Bromo-2-methoxypyridine 95% | 100367-39-3 | 1g | $12 | 2026-05-06 | Buy |
| Synthonix | B3113 | 4-Bromo-2-methoxypyridine 95% | 100367-39-3 | 5g | $21 | 2026-05-06 | Buy |
4-Bromo-2-methoxypyridine Chemical Properties,Uses,Production
Uses
4-Bromo-2-methoxypyridine used in the synhesis of Imidazo [1, 2-a] pyrimidines. Suzuki coupling between 4-methoxyphenylboronic acid and 4-bromo-2-methoxypyridine affords 1, 5-disubstituted pyridones. Starting material used in a synthesis of crown-ester-bipyridines and viologens via sodium or nickel reductive coupling, side chain oxidation and esterification.
Synthesis
128071-98-7
124-41-4
100367-39-3
A non-homogeneous reaction mixture formed by 4-bromo-2-fluoropyridine (2.64 mL, 25.6 mmol) and sodium methanolate (8.29 g, 153 mmol) in methanol (36.5 mL) was placed in a pressure tube and reacted for 5 hours at 155°C. Upon completion of the reaction, the mixture was cooled to room temperature, filtered to remove the solid insoluble material and the solids were washed with ethyl acetate. The filtrate was concentrated to give a light yellow oil containing a small amount of white solid. The yellow oily material was decanted, diluted with water and the aqueous phase was extracted with ethyl acetate (2×). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated to afford the target product 4-bromo-2-methoxypyridine (4.43 g, 21.20 mmol, 83% yield) as a yellow oil.LC-MS analysis: the calculated value of C6H6BrNO was 188.02, and the measured values of [M + H]+ were 187.9, 189.9. 1H NMR was used as the analyte. 189.9. 1H NMR (400 MHz, CDCl3) δ 7.98 (d, J = 5.5 Hz, 1H), 7.02 (dd, J = 5.5, 1.5 Hz, 1H), 6.94 (d, J = 1.8 Hz, 1H), 3.92 (s, 3H).
References
[1] Patent: WO2015/171722, 2015, A1. Location in patent: Page/Page column 67
4-Bromo-2-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
View Lastest Price from 4-Bromo-2-methoxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 4-Bromo-2-methoxypyridine
100367-39-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-09-25 | 4-Bromo-2-methoxypyridine
100367-39-3
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-04 | 4-Bromo-2-methoxypyridine
100367-39-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 4-Bromo-2-methoxypyridine
100367-39-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-Bromo-2-methoxypyridine
100367-39-3
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 4-Bromo-2-methoxypyridine
100367-39-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
