DEHYDRO ARIPIPRAZOLE
- CAS No.
- 129722-25-4
- Chemical Name:
- DEHYDRO ARIPIPRAZOLE
- Synonyms
- Aripiprazole Related CoMpound G;7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one;DM-14857;OPC-14857;DEHYDRO ARIPIPRAZOLE;Aripiprazole (IMP G);Aripiprazole USP RC G;Aripiprazole impurities1779;7-(4-(4-(2,3-Dichlorophenyl);Dehydro aripiprazole solution
- CBNumber:
- CB5372951
- Molecular Formula:
- C23H25Cl2N3O2
- Molecular Weight:
- 446.37
- MDL Number:
- MFCD00892073
- MOL File:
- 129722-25-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Aripiprazole Related Compound G Pharmaceutical Secondary Standard; Certified Reference Material | PHR2323 | 100MG | $668 |
| Dehydro aripiprazole solution 1.0?mg/mL in methanol with 5% 1 M HCl, ampule of 1?mL, certified reference material, Cerilliant? | D-053 | 1mL | $275 |
| Dehydro aripiprazole solution | 1042690 | 25mg | $1390 |
| Dehydro Aripiprazole >95%(HPLC) | TRC-D229155-5MG | 5mg | $299 |
| Dehydro Aripiprazole >95%(HPLC) | TRC-D229155-25MG | 25mg | $900 |
| More product size | |||
| Melting point | >139oC (dec.) |
|---|---|
| Boiling point | 654.4±55.0 °C(Predicted) |
| Density | 1.281±0.06 g/cm3(Predicted) |
| Flash point | 349℃ |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 11.22±0.70(Predicted) |
| color | White to Off-White |
| Major Application | pharmaceutical small molecule |
| InChI | 1S/C23H25Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-9,16H,1-2,10-15H2,(H,26,29) |
| InChIKey | CDONPRYEWWPREK-UHFFFAOYSA-N |
| SMILES | Clc1c(cccc1N2CCN(CC2)CCCCOc3cc4[nH][c](ccc4cc3)=O)Cl |
| FDA UNII | 2S514OZH3B |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS05,GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H290-H301+H311+H331-H370 |
| Precautionary statements | P210-P233-P280-P301+P310-P303+P361+P353-P304+P340+P311 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25-52/53 |
| Safety Statements | 16-36/37-45-61 |
| RIDADR | UN 3286 8(6.1)(3) / PGII |
| WGK Germany | 1 |
| HS Code | 2933790002 |
| Storage Class | 11 - Combustible Solids |
DEHYDRO ARIPIPRAZOLE price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2323 | Aripiprazole Related Compound G Pharmaceutical Secondary Standard; Certified Reference Material | 129722-25-4 | 100MG | $668 | 2026-04-30 | Buy |
| Sigma-Aldrich | D-053 | Dehydro aripiprazole solution 1.0?mg/mL in methanol with 5% 1 M HCl, ampule of 1?mL, certified reference material, Cerilliant? | 129722-25-4 | 1mL | $275 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1042690 | Dehydro aripiprazole solution | 129722-25-4 | 25mg | $1390 | 2026-04-30 | Buy |
| TRC | TRC-D229155-5MG | Dehydro Aripiprazole >95%(HPLC) | 129722-25-4 | 5mg | $299 | 2026-06-03 | Buy |
| TRC | TRC-D229155-25MG | Dehydro Aripiprazole >95%(HPLC) | 129722-25-4 | 25mg | $900 | 2026-06-03 | Buy |
DEHYDRO ARIPIPRAZOLE Chemical Properties,Uses,Production
Uses
Dehydro Aripiprazole (Aripiprazole EP Impurity E; Aripiprazole USP Related Compound G) is an impurity of Aripiprazole (A771000), a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity.
General Description
Dehydro Aripiprazole is the primary, active metabolite of aripiprazole, marketed as the atypical antipsychotic Abilify for the treatment of schizophrenia, bipolar disorder, and clinical depression. This new certified solution standard is suitable for use in LC or GC applications including forensic or clinical toxicology analysis and urine drug testing.
Synthesis
129722-12-9
129722-25-4
The general procedure for the synthesis of 7-[4-[4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy]-3,4-dihydroquinolin-2(1H)-ones from 7-(4-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butoxy)-2(1H)-quinolinone was as follows: Example 1: Large-scale synthesis of dehydroaripiprazole [7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one] (Compound 1; Formula VI) Aripiprazole (Formula VIA) 1. 15 g (0.03 mol) of 7-(4-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one was dissolved in 360 mL of anhydrous tetrahydrofuran to form a clarified solution. 2. 12 mL (0.16 mol) of trifluoroacetic acid was added to the solution. 3. 24.3 g (0.11 mol) of 1,2-dichloro-4,5-dicyanoquinone was added and the mixture was stirred at room temperature under a nitrogen atmosphere. 4. After the reaction was stirred for 40 minutes, TLC assay showed complete consumption of the raw material. 5. 1.5 L of water was added and then the reaction mixture was alkalized to pH 12 with 50% NaOH aqueous solution. 6. The reaction mixture was extracted with dichloromethane (3 x 300 mL), the organic phases were combined and dried with MgSO4. 7. The crude product was purified by column chromatography using silica as stationary phase and dichloromethane to 10% methanol/dichloromethane as eluent. 8. The product was purified by 2-propanolysis. 8. The product was further purified by recrystallization from 2-propanol to give 13.7 g (92%) of off-white solid target product. Product characterization: 1H-NMR (400 MHz, CDCl3) δ 12.33 (1H, br s), 7.72 (1H, d), 7.42 (1H, d), 7.16-7.11 (2H, m), 6.98-6.93 (1H, dd), 6.83-6.79 (2H, m), 6.53 (1H, d), 4.10 (2H, t), 3.09 (4H, br), 4.10 (2H, t), 4.10 (2H, t). 3.09 (4H, br s), 2.67 (4H, br s), 2.52 (2H, t), 1.93-1.70 (4H, m). LCMS (acidic method) [M + H]+ 446.02, rt 14.246 min.
References
[1] Patent: US2011/275803, 2011, A1. Location in patent: Page/Page column 60-61
[2] Crystal Growth and Design, 2013, vol. 13, # 5, p. 2036 - 2046
[3] Heterocyclic Communications, 2005, vol. 11, # 6, p. 485 - 490
DEHYDRO ARIPIPRAZOLE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
View Lastest Price from DEHYDRO ARIPIPRAZOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Dehydroaripiprazole
129722-25-4
|
$72.00-247.00 | 98.70% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-21 | Dehydroaripiprazole
129722-25-4
|
$72.00-247.00 | 98.70% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-02-01 | DEHYDRO ARIPIPRAZOLE
129722-25-4
|
$1.00 | 1KG | 98% | 200kgs | Career Henan Chemical Co |
-
- Dehydroaripiprazole
129722-25-4
- $72.00-247.00
- 98.70%
- TargetMol Chemicals Inc.
-
- Dehydroaripiprazole
129722-25-4
- $72.00-247.00
- 98.70%
- TargetMol Chemicals Inc.
-
- DEHYDRO ARIPIPRAZOLE
129722-25-4
- $1.00
- 98%
- Career Henan Chemical Co
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