2,6-Difluorobenzamide
- CAS No.
- 18063-03-1
- Chemical Name:
- 2,6-Difluorobenzamide
- Synonyms
- 2,6-difluorobenzoic acid amide;uorobenzamide;Compound Fr13974;2,6-Difluorbenzamid;2,6-DIFLUOROBENZAMIDE;2,6-difluoro-benzamid;2，6-difluorobenzaminde;2,6-Difluorobenzoamide;2,6-Difluorobenzoylamide;2,6-Difluorobenzamide97%
- CBNumber:
- CB5376515
- Molecular Formula:
- C7H5F2NO
- Molecular Weight:
- 157.12
- MDL Number:
- MFCD00007972
- MOL File:
- 18063-03-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2,6-Difluorobenzamide 97% | 282278 | 10g | $41.4 |
| 2,6-Difluorobenzamide 97% | 282278 | 50g | $113 |
| 2,6-Difluorobenzamide >97.0%(N) | D1907 | 25g | $44 |
| 2,6-Difluorobenzamide | TRC-D451843-5G | 5g | $78 |
| 2,6-Difluorobenzamide | TRC-D451843-1G | 1g | $68 |
| More product size | |||
| Melting point | 145-148 °C (lit.) |
|---|---|
| Boiling point | 51-52C/15Tor |
| Density | 1,199g/cm |
| refractive index | 1,508 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | ethanol: soluble5%, clear to turbid, colorless to light yellow |
| form | Solid |
| pka | 14.54±0.50(Predicted) |
| color | Off-White |
| BRN | 2047480 |
| InChI | 1S/C7H5F2NO/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H2,10,11) |
| InChIKey | AVRQBXVUUXHRMY-UHFFFAOYSA-N |
| SMILES | NC(=O)c1c(F)cccc1F |
| LogP | 0.011-0.25 at 25℃ |
| CAS DataBase Reference | 18063-03-1(CAS DataBase Reference) |
| FDA UNII | SJ2RN214MK |
| NIST Chemistry Reference | Benzamide, 2,6-difluoro-(18063-03-1) |
| EPA Substance Registry System | Benzamide, 2,6-difluoro- (18063-03-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20 | |||||||||
| Safety Statements | 26-37/39-36/37 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | CV4355050 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | rat,LC50,inhalation,> 2100mg/m3/4H (2100mg/m3),National Technical Information Service. Vol. OTS0543293, | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,6-Difluorobenzamide price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 282278 | 2,6-Difluorobenzamide 97% | 18063-03-1 | 10g | $41.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 282278 | 2,6-Difluorobenzamide 97% | 18063-03-1 | 50g | $113 | 2026-04-30 | Buy |
| TCI Chemical | D1907 | 2,6-Difluorobenzamide >97.0%(N) | 18063-03-1 | 25g | $44 | 2026-04-30 | Buy |
| TRC | TRC-D451843-5G | 2,6-Difluorobenzamide | 18063-03-1 | 5g | $78 | 2026-06-03 | Buy |
| TRC | TRC-D451843-1G | 2,6-Difluorobenzamide | 18063-03-1 | 1g | $68 | 2026-06-03 | Buy |
2,6-Difluorobenzamide Chemical Properties,Uses,Production
Description
2,6-Difluorobenzamide is a major metabolite of pesticide diflubenzuron and has been quantitated by HPLC/diode-array method.
Description
2,6-Difluorobenzamide is a white powdery crystal, insoluble in water. It can be obtained by hydrolysis of 2,6-difluorobenzonitrile. 2,6-Difluorobenzamide is an important intermediate in the synthesis process of benzoylurea insecticides, which is used to synthesize the next intermediate 2,6-difluorobenzoyl isocyanate, and finally obtain flubolurea, pyruron, fluridin, lice mite urea and other pesticide varieties. It can also be directly used to synthesize pyruron and flubolea. 2,6-Difluorobenzamide can inhibit the bacterial cell division protein FtsZ[1].
Chemical Properties
white to yellowish powder
Uses
2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates. It is also used in the synthesis of pesticide intermediates, which can be used to produce various insecticides such as fluazuron, chlorpyrifos, and pyrethroids.
Preparation
2,6-Difluorobenzamide is obtained by hydrolysis of 2,6-difluorobenzonitrile.
Synthesis
1897-52-5
18063-03-1
General procedure for the synthesis of 2,6-difluorobenzamide from 2,6-difluorobenzonitrile: (1) 100 g (0.72 mol) of 2,6-difluorobenzonitrile was added slowly and dropwise to a mixed solution of 240 g of concentrated sulfuric acid and 24 ml of water at room temperature. The reaction mixture was stirred at 80°C to 85°C for 12 hours. After completion of the reaction, the mixture was slowly poured into 1.2 kg of ice water and stirred continuously for 30 minutes, followed by filtration. The resulting crystals were washed to neutrality with distilled water and finally dried under vacuum at 85°C. The yield was 91.0 g (80.6% yield) with a melting point of 140°C to 141.5°C.
Toxics Screening Level
The Initial Threshold Screening Level (ITSL) for 2,6-Difluorobenzamide is 11 μg/m3 based on an annual averaging time.
References
[1] Straniero V, et al. 2,6-Difluorobenzamide inhibitors of the bacterial cell division protein FtsZ: design, synthesis and Structure Activity Relationship study. ChemMedChem, 2017; 12: 1303-1318.
2,6-Difluorobenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shandong exelon biochem co.ld | +86-533-2119995 +8615053330977 | 451614802@QQ.com | China | 96 | 58 |
| AS WATER CO., LTD. | +86-18994963526 +8618994963526 | 1346073549@qq.com | United Kingdom | 176 | 58 |
| Henan Allgreen Chemical Co.,LTD | +86-37155567971 +86-13633837469 | info@allgreenchem.com | China | 6000 | 58 |
| Ningxia Jinhua Chemical Co.,Ltd | +86-025-52279164 +8615996340606 | info@nxjhchem.com | China | 79 | 58 |
| Anhui Royal Chemical Co., Ltd. | +86-025-86655873 +86-13962173137 | marketing@royal-chem.com | China | 201 | 55 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shanghai Cube Chemical Co., Ltd. | +86-02156500520 +86-18116101847 | kevin.li@cubechem.com | China | 43 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
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- Apr 15，2026
View Lastest Price from 2,6-Difluorobenzamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-20 | 2,6-Difluorobenzamide
18063-03-1
|
$1.00 | 200KG | 99% | 20ton | Anhui Royal Chemical Co., Ltd. | |
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2026-07-20 | 2,6-Difluorobenzamide
18063-03-1
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-16 | 2,6-Difluorobenzamide
18063-03-1
|
$300.00-20000.00 | 1000kg | 0.98 | 100 Metric Ton/Metric Tons per Year | Wuxi High Mountain Hi-tech Development Co.,Ltd. |
-
- 2,6-Difluorobenzamide
18063-03-1
- $1.00
- 99%
- Anhui Royal Chemical Co., Ltd.
-
- 2,6-Difluorobenzamide
18063-03-1
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2,6-Difluorobenzamide
18063-03-1
- $300.00-20000.00
- 0.98
- Wuxi High Mountain Hi-tech Development Co.,Ltd.
