CELECOXIB-D7
- CAS No.
- 544686-21-7
- Chemical Name:
- CELECOXIB-D7
- Synonyms
- D7-Celecoxib;CELECOXIB-D7;Celecoxiβ-d7;[2H7]-Celecoxib;Celecoxib-D7 (Standard);4-[5-[4-(methyl-d3)phenyl-2,3,5,6-d4]-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide;4-[5-[2,3,5,6-tetradeuterio-4-(trideuteriomethyl)phenyl]-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide;Celecoxib D7Q: What is Celecoxib D7 Q: What is the CAS Number of Celecoxib D7 Q: What is the storage condition of Celecoxib D7 Q: What are the applications of Celecoxib D7
- CBNumber:
- CB5388385
- Molecular Formula:
- C17H7D7F3N3O2S
- Molecular Weight:
- 388.42
- MDL Number:
- MFCD08063418
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360-H400-H410 |
| Precautionary statements | P201-P202-P273-P280-P308+P313-P391-P405-P501 |
CELECOXIB-D7 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18248 | Celecoxib-d7 ≥99%deuteratedforms(d1-d7) | 544686-21-7 | 500μg | $117 | 2026-04-30 | Buy |
| Cayman Chemical | 18248 | Celecoxib-d7 ≥99%deuteratedforms(d1-d7) | 544686-21-7 | 1mg | $218 | 2026-04-30 | Buy |
| Cayman Chemical | 18248 | Celecoxib-d7 ≥99%deuteratedforms(d1-d7) | 544686-21-7 | 5mg | $909 | 2026-04-30 | Buy |
| TRC | TRC-C251004-1MG | Celecoxib-d7 | 544686-21-7 | 1mg | $365 | 2026-06-03 | Buy |
| TRC | TRC-C251004-10MG | Celecoxib-d7 | 544686-21-7 | 10mg | $2658 | 2026-06-03 | Buy |
CELECOXIB-D7 Chemical Properties,Uses,Production
Description
Celecoxib-d7 is intended for use as an internal standard for the quantification of celecoxib by GC- or LC-MS. Celecoxib is a selective inhibitor of COX-2 (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively). It displays chemopreventive activity in multiple tumor types via proapoptotic effects that are independent of COX-2 inhibition. Formulations containing celecoxib have been used in the treatment of inflammation while circumventing the gastrointestinal toxicity associated with traditional non-sterodial anti-inflammatory drugs, however, the use of celecoxib has been tempered due to its ability to induce adverse cardiovascular events.
Uses
Celecoxib-d7 is the labeled analogue of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis.
References
[1] MD.JASHIM UDDIN Edward E K P N Praveen Rao. Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere[J]. Bioorganic & Medicinal Chemistry, 2003, 11 23: Pages 5273-5280. DOI: 10.1016/j.bmc.2003.07.005
[2] I A MARDINI G A F. Selective inhibitors of cyclooxygenase-2: a growing class of anti-inflammatory drugs.[J]. Molecular interventions, 2001, 1 1: 30-38.
[3] VERENA JENDROSSEK Claus B René Handrick. Celecoxib activates a novel mitochondrial apoptosis signaling pathway[J]. FASEB Journal, 2003, 17 11: 1-25. DOI: 10.1096/fj.02-0947fje
[4] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[5] JIUXIANG ZHU. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors.[J]. Cancer research, 2004, 64 12: 4309-4318. DOI: 10.1158/0008-5472.can-03-4063
CELECOXIB-D7 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Cato Research Chemicals Inc. | 020-81960175 | min.he@cato-chem.com | China | 1949 | 55 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Artis Biotech Co. Ltd. | 18108108965 18108108965 | sales@artisbio.com | China | 2503 | 58 |
| Shanghai Champ Biopharmaceuticals Co., Ltd. | 021-61537865 13585780846 | sales@champchem.com | China | 442 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
| Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 17361806303 | kexin.zhou@haolvbiotech.com | China | 3009 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Zhuzhou focus pharmaceutical technology co., LTD | +86-13776644403 | robert@focuspharma.cc | China | 2613 | 58 |
