Ethyl oxazole-4-carboxylate
- CAS No.
- 23012-14-8
- Chemical Name:
- Ethyl oxazole-4-carboxylate
- Synonyms
- ETHYL 4-OXAZOLECARBOXYLATE;Ethyl 1,3-oxazole-4-carboxylate;4-Oxa;4-OxazoL;4-ethoxycarbonyloxazole;ETHYL OXAZOLE-4-CARBOXYLATE;Ethyl4-Oxazolecarboxylate>Ethyl 4-oxazolecarboxylate 97%;4-(Ethoxycarbonyl)-1,3-oxazole;Ethyl 1,3-oxazole-4-carboxylate 97%
- CBNumber:
- CB5397765
- Molecular Formula:
- C6H7NO3
- Molecular Weight:
- 141.12
- MDL Number:
- MFCD04114940
- MOL File:
- 23012-14-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 48°C |
|---|---|
| Boiling point | 101°C 14mm |
| Density | 1.177 g/mL at 25 °C |
| refractive index | n20/D 1.467 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to lump to clear liquid |
| pka | 0.38±0.10(Predicted) |
| color | White or Colorless to Almost white or Almost colorless |
| InChI | InChI=1S/C6H7NO3/c1-2-10-6(8)5-3-9-4-7-5/h3-4H,2H2,1H3 |
| InChIKey | UBESIXFCSFYQNK-UHFFFAOYSA-N |
| SMILES | O1C=C(C(OCC)=O)N=C1 |
| CAS DataBase Reference | 23012-14-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xi |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 2934999090 |
| Storage Class | 11 - Combustible Solids |
Ethyl oxazole-4-carboxylate price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 696625 | Ethyl 4-oxazolecarboxylate 97% | 23012-14-8 | 1g | $81.5 | 2023-06-20 | Buy |
| TCI Chemical | O0289 | Ethyl 4-Oxazolecarboxylate >96.0%(GC) | 23012-14-8 | 1g | $31 | 2026-04-30 | Buy |
| TCI Chemical | O0289 | Ethyl 4-Oxazolecarboxylate >96.0%(GC) | 23012-14-8 | 5g | $90 | 2026-04-30 | Buy |
| AstaTech | 25319 | ETHYL OXAZOLE-4-CARBOXYLATE 95% | 23012-14-8 | 5G | $17 | 2026-04-30 | Buy |
| AstaTech | 25319 | ETHYL OXAZOLE-4-CARBOXYLATE 95% | 23012-14-8 | 25G | $53 | 2026-04-30 | Buy |
Ethyl oxazole-4-carboxylate Chemical Properties, Uses, Production
Uses
Used for the Palladium-Catalyzed Synthesis of (Hetero)aryloxazoles.[1]
Synthesis
2949-22-6
23012-14-8
The general procedure for the synthesis of ethyl oxazole-4-carboxylate from ethyl isocyanoylacetate was as follows: formic acid (8.62 mL, 228 mmol) was added in batches to anhydrous THF (200 mL), and the phenomenon of gas escape was observed. The mixture was stirred for 30 min to form a sol. Subsequently, a solution of ethyl isocyanoacetate (25 mL, 228 mmol) and triethylamine (Et3N, 60.5 mL, 434 mmol) was added to the reaction mixture. The mixture was stirred at room temperature for 1 hour and then changed to reflux conditions overnight. After the reaction was completed, the mixture was cooled to room temperature. Water was added and the mixture was extracted with ether (Et2O, 3 times). The organic phases were combined, dried with magnesium sulfate (MgSO4), filtered and concentrated. The residue was purified by fast column chromatography (FC, eluent: ethyl acetate/heptane, ratio graded from 1:5 to 1:3 and finally to 1:1) to afford ethyl oxazole-4-carboxylate (27.2 g, 84% yield). LC-MS analysis resulted in a retention time (tR) = 0.58 min and a mass-to-charge ratio in the electrosprayed positive ion mode (ES+) (m/z) = 142.07 .
References
[1] CéCILE VERRIER. Palladium-Catalyzed Direct (Hetero)arylation of Ethyl Oxazole-4-carboxylate: An Efficient Access to (Hetero)aryloxazoles[J]. The Journal of Organic Chemistry, 2008, 73 18: 7383-7386. DOI:10.1021/jo801093n.
Ethyl oxazole-4-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hunan HuaTeng Pharmaceutical Co., Ltd., | 400-8592883 15367835770 | sales@huatengsci.com | China | 5869 | 58 |
| Yangzhou beierdun new material technology co., ltd | 13776432722 | 358854490@qq.com | China | 39 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from Ethyl oxazole-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Ethyl oxazole-4-carboxylate
23012-14-8
|
$1.60-6.60 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2024-02-29 | Ethyl 4-Oxazolecarboxylate
23012-14-8
|
$680.00 | 1g | 97 | 500 Kg | R&D Scientific Inc. | |
 |
2021-07-02 | Ethyl oxazole-4-carboxylate
23012-14-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Ethyl oxazole-4-carboxylate
23012-14-8
- $1.60-6.60
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Ethyl 4-Oxazolecarboxylate
23012-14-8
- $680.00
- 97
- R&D Scientific Inc.
-
- Ethyl oxazole-4-carboxylate
23012-14-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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