TACRINE HYDROCHLORIDE
- CAS No.
- 1684-40-8
- Chemical Name:
- TACRINE HYDROCHLORIDE
- Synonyms
- TACRINE;COGNEX;TACRINE HCL;hydroaminacrine;ci970;ROMOTAL;tenakrin;THA Dihydrate;Romotal Dihydrate;Tenakrin Dihydrate
- CBNumber:
- CB5402661
- Molecular Formula:
- C13H15ClN2
- Molecular Weight:
- 234.72
- MDL Number:
- MFCD00012657
- MOL File:
- 1684-40-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tacrine (hydrochloride) ≥98% | 70240 | 1g | $40 |
| Tacrine (hydrochloride) ≥98% | 70240 | 5g | $129 |
| Tacrine hydrochloride Asreported | 256797 | 100mg | $296 |
| 9-Amino-1,2,3,4-tetrahydroacridine Hydrochloride Dihydrate | TRC-A629700-2.5G | 2.5g | $83 |
| 9-Amino-1,2,3,4-tetrahydroacridine Hydrochloride Dihydrate | TRC-A629700-1G | 1g | $63 |
| More product size | |||
| Melting point | 280-284 °C(lit.) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in aqueous buffers |
| pka | pKa 9.8 (Uncertain) |
| form | Crystalline solid |
| color | White to light yellow |
| InChI | InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H |
| InChIKey | ZUFVXZVXEJHHBN-UHFFFAOYSA-N |
| SMILES | C12=CC=CC=C1C(N)=C1CCCCC1=N2.Cl |
| CAS DataBase Reference | 1684-40-8(CAS DataBase Reference) |
| FDA UNII | 4966RNG0BU |
| ATC code | N06DA01 |
| EPA Substance Registry System | Tacrine hydrochloride (1684-40-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H331-H301-H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338-P261-P280a-P304+P340-P405-P501a | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 25-36/37/38-20/22 | |||||||||
| Safety Statements | 26-36-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AR9532500 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 intravenous in mouse: 5600ug/kg | |||||||||
| NFPA 704 |
|
TACRINE HYDROCHLORIDE price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 70240 | Tacrine (hydrochloride) ≥98% | 1684-40-8 | 1g | $40 | 2026-04-30 | Buy |
| Cayman Chemical | 70240 | Tacrine (hydrochloride) ≥98% | 1684-40-8 | 5g | $129 | 2026-04-30 | Buy |
| Usbiological | 256797 | Tacrine hydrochloride Asreported | 1684-40-8 | 100mg | $296 | 2026-06-03 | Buy |
| TRC | TRC-A629700-2.5G | 9-Amino-1,2,3,4-tetrahydroacridine Hydrochloride Dihydrate | 1684-40-8 | 2.5g | $83 | 2026-06-03 | Buy |
| TRC | TRC-A629700-1G | 9-Amino-1,2,3,4-tetrahydroacridine Hydrochloride Dihydrate | 1684-40-8 | 1g | $63 | 2026-06-03 | Buy |
TACRINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Tacrine is the first therapeutic launched specifically for the treatment of Alzheimer's disease which affects four million people in the US alone. Clinically significant improvement in cognition has been demonstrated in the patients with Alzheimer's disease. Although the cause of Alzheimer's disease is not understood, degeneration of cholinergic neurons is thought to be a primary factor in the development and progression of the disease. Tacrine is a reversible acetylcholinesterase inhibitor that presumably acts centrally by elevating the acetylcholine level in the cerebral cortex and by slowing degradation of acetylcholine from intact cholinergic neurons. While tacrine improves the symptoms of Alzheimer's disease, the underlining cause of the dementing process is not altered. It has also been suggested that the beneficial effects of tacrine may be due to its multiple effects on several neurotransmitter systems.
Description
Tacrine is a derivative of aminoacridine that functions as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively). Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and decreases depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. Formulations containing tacrine have been used clinically in the treatment of Alzheimer’s disease.
Chemical Properties
Pale Yellow Solid
Originator
NIH (U.S.A.)
Uses
anticholinesterase, cognitive adjuvant, K channel blocker
Uses
A potent centrally acting anticholinesterase, for therapy of memory deficits in patients with Alzheimers disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholi
Uses
A potent centrally acting anticholinesterase for therapy of memory deficits in patients with Alzheimer's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.
brand name
Cognex (Sciele).
General Description
Tacrine hydrochloride,1,2,3,4-tetrahydro-9-aminoacridine hydrochloride (THA,Cognex), is a reversible cholinesterase inhibitor that hasbeen used in the treatment of Alzheimer disease for severalyears. The drug has been used to increase the levels of AChin these patients on the basis of observations from autopsiesthat concentrations of ChAT and AChE are markedly reducedin the brain, whereas the number of muscarinic receptorsis almost normal. The use of the drug is not withoutcontroversy, as conflicting results on efficacy have been reported.The drug has been used in mild-to-moderateAlzheimer dementia.
General Description
Yellow needles (from concentrated hydrochloric acid); white powder. pH of 1.5% solution: 4.5-6. Bitter taste.
Air & Water Reactions
Water soluble.
Reactivity Profile
TACRINE HYDROCHLORIDE is incompatible with strong oxidizing agents, acid chlorides and acid anhydrides . Neutralize bases in slightly exothermic reactions.
Fire Hazard
Flash point data for TACRINE HYDROCHLORIDE are not available; however, TACRINE HYDROCHLORIDE is probably combustible.
Biological Activity
Potent cholinesterase inhibitor, a cognition enhancer in vivo .
Metabolism
Tacrine is extensively metabolized by CYP450 to at least three metabolites. The major metabolite, 1-hydroxy-tacrine, is active. Its elimination half-life is between 1.5 and 4 hours, with metabolites being are excreted via the urine.
References
[1] CRISMON M L. Pharmacokinetics and drug interactions of cholinesterase inhibitors administered in Alzheimer’s disease.[J]. Pharmacotherapy, 1998, 18 2 Pt 2: 47-54; discussion 79-82.
[2] MUSHTAQ AHMED. Inhibition of two different cholinesterases by tacrine[J]. Chemico-Biological Interactions, 2006, 162 2: Pages 165-171. DOI: 10.1016/j.cbi.2006.06.002
[3] B. DRUKARCH J. C S J E Leysen. Further analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer’s disease[J]. Life sciences, 1988, 42 9: Pages 1011-1017. DOI: 10.1016/0024-3205(88)90431-6
[4] MAUREEN T. MCKENNA. Novel Tacrine Analogues for Potential Use against Alzheimer’s Disease: Potent and Selective Acetylcholinesterase Inhibitors and 5-HT Uptake Inhibitors[J]. Journal of Medicinal Chemistry, 1997, 40 22: 3516-3523. DOI: 10.1021/jm970150t
[5] VLADIMIR DOLEAL Stanislav T Věra Lisá. Effect of tacrine on intracellular calcium in cholinergic SN56 neuronal cells[J]. Brain Research, 1997, 769 2: Pages 219-224. DOI: 10.1016/s0006-8993(97)00711-7
[6] GIACOBINI E. Invited Review Cholinesterase inhibitors for Alzheimer’s disease therapy: from tacrine to future applications[J]. Neurochemistry international, 1998, 32 5: Pages 413-419. DOI: 10.1016/s0197-0186(97)00124-1
[7] GARY TIN. Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer’s disease[J]. MedChemComm, 2015, 6 1: 1930-1941. DOI: 10.1039/c5md00274e
TACRINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13523716970 | Lingzhiyue@aliyun.com | China | 3145 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
View Lastest Price from TACRINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | 1,2,3,4-Tetrahydroacridin-9-amine hydrochloride
1684-40-8
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2026-04-20 | Tacrine hydrochloride
1684-40-8
|
$127.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-06-25 | TACRINE HYDROCHLORIDE
1684-40-8
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd |
-
- 1,2,3,4-Tetrahydroacridin-9-amine hydrochloride
1684-40-8
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- Tacrine hydrochloride
1684-40-8
- $127.00
- TargetMol Chemicals Inc.
-
- TACRINE HYDROCHLORIDE
1684-40-8
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
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