ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE
- CAS No.
- 1196152-00-7
- Chemical Name:
- ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE
- Synonyms
- ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE;2-Chloro-pyrimidine-4-carboxylic acid ethyl ester;4-PyriMidinecarboxylic acid, 2-chloro-, ethyl ester;2-Chloro-4-(ethoxycarbonyl)pyrimidine, 2-Chloro-4-(ethoxycarbonyl)-1,3-diazine
- CBNumber:
- CB5410044
- Molecular Formula:
- C7H7ClN2O2
- Molecular Weight:
- 186.6
- MDL Number:
- MFCD08275109
- MOL File:
- Mol file
ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E938268 | Ethyl2-Chloropyrimidine-4-carboxylate | 1196152-00-7 | 50mg | $65 | 2021-12-16 | Buy |
| AK Scientific | 3372AA | Ethyl2-chloropyrimidine-4-carboxylate | 1196152-00-7 | 250mg | $122 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | C12996 | Ethyl2-chloropyrimidine-4-carboxylate 95% | 1196152-00-7 | 1g | $150 | 2021-12-16 | Buy |
| AK Scientific | 3372AA | Ethyl2-chloropyrimidine-4-carboxylate | 1196152-00-7 | 1g | $190 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0355963 | ETHYL-2-CHLOROPYRIMIDINE-4-CARBOXYLATE 95.00% | 1196152-00-7 | 5MG | $498.25 | 2021-12-16 | Buy |
ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE Chemical Properties,Uses,Production
Synthesis
149849-92-3
64-17-5
1196152-00-7
To 2-chloropyrimidine-4-carboxylic acid (9.A, 1.00 g, 6.3 mmol) and ethanol (0.32 g, 6.9 mmol) in dichloromethane (DCM, 10 ml) was added 1,3-dicyclohexylcarbodiimide (DCC, 1.4 g, 6.9 mmol) and the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solid by-products were removed by filtration. The filtrate was diluted by adding DCM (80 ml) and subsequently washed with brine (30 ml) and dried over anhydrous magnesium sulfate (MgSO4). The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by Combi-Flash silica gel column chromatography to afford the target compound ethyl 2-chloropyrimidine-4-carboxylate (9.B, 0.74 g, 63% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.87 (1H, d, J=4.7 Hz), 7.95 (1H, d, J=4.7 Hz), 4.51 (2H, q, J=7.4 Hz), 1.45 (3H, t, J=7.0 Hz). The mass spectrum (ESI+) showed m/e: 187.0 ([M+H]+).
References
[1] Patent: WO2010/93849, 2010, A2. Location in patent: Page/Page column 53
[2] Patent: WO2014/69963, 2014, A1. Location in patent: Paragraph 616-617
ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1299 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43339 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Atop-Pharma (Shanghai) Technology Co., Ltd. | +86 (21) 5196-9732 | China | 996 | 57 |
