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2,4,6-Trimethylaniline

2,4,6-Trimethylaniline Structure
2,4,6-Trimethylaniline structure
CAS No.
88-05-1
Chemical Name:
2,4,6-Trimethylaniline
Synonyms
MESIDINE;MESITYLAMINE;2,4,6-trimethylbenzenamine;2-AMINO-1,3,5-TRIMETHYLBENZENE;2,4,6-Trimethylanilinehydrochloride;Mesidin;Mezidine;MESIDENE;AMINOMESITYLENE;Isotritoluidine
CBNumber:
CB5410640
Molecular Formula:
C9H13N
Molecular Weight:
135.21
MDL Number:
MFCD00007740
MOL File:
88-05-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:41:03
Product description Number Pack Size Price
2,4,6-Trimethylaniline 98% 132179 25ml $51.8
2,4,6-Trimethylaniline 98% 132179 100ml $57.9
2,4,6-Trimethylaniline >99.0%(GC) T0467 25mL $25
2,4,6-Trimethylaniline >99.0%(GC) T0467 100mL $42
2,4,6-Trimethylaniline Asreported 289810 25g $333
More product size
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2,4,6-Trimethylaniline Properties

Melting point -5 °C
Boiling point 108-110 °C11 mm Hg(lit.)
Density 0.963 g/mL at 25 °C(lit.)
refractive index n20/D 1.551(lit.)
Flash point 205 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka pK1:4.38(+1) (25°C)
form liquid (clear)
color clear brown
Water Solubility IMMISCIBLE
BRN 636559
Henry's Law Constant 3.7×100 mol/(m3Pa) at 25℃, HSDB (2015)
InChI 1S/C9H13N/c1-6-4-7(2)9(10)8(3)5-6/h4-5H,10H2,1-3H3
InChIKey KWVPRPSXBZNOHS-UHFFFAOYSA-N
SMILES Cc1cc(C)c(N)c(C)c1
CAS DataBase Reference 88-05-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII YIR5CRL5BG
IARC 3 (Vol. 27, Sup 7) 1987
NIST Chemistry Reference Benzenamine, 2,4,6-trimethyl-(88-05-1)
EPA Substance Registry System 2,4,6-Trimethylaniline (88-05-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H302+H312-H315-H319-H330
Precautionary statements  P260-P280-P301+P312-P302+P352+P312-P304+P340+P310-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  T+,T
Risk Statements  21/22-26-36/38-33-23/24/25
Safety Statements  26-28-36/37-45-28A
RIDADR  UN 2810 6.1/PG 2
WGK Germany  3
RTECS  BZ0700000
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29214980
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 1 Inhalation
Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Hazardous Substances Data 88-05-1(Hazardous Substances Data)
REACH Registrations Active
Limited Quantities 100ml (liquid) or 0.5 Kg (solid)
Excepted Quantities Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
2 0

2,4,6-Trimethylaniline price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 132179 2,4,6-Trimethylaniline 98% 88-05-1 25ml $51.8 2026-04-30 Buy
Sigma-Aldrich 132179 2,4,6-Trimethylaniline 98% 88-05-1 100ml $57.9 2026-04-30 Buy
TCI Chemical T0467 2,4,6-Trimethylaniline >99.0%(GC) 88-05-1 25mL $25 2026-04-30 Buy
TCI Chemical T0467 2,4,6-Trimethylaniline >99.0%(GC) 88-05-1 100mL $42 2026-04-30 Buy
Usbiological 289810 2,4,6-Trimethylaniline Asreported 88-05-1 25g $333 2026-06-03 Buy
Product number Packaging Price Buy
132179 25ml $51.8 Buy
132179 100ml $57.9 Buy
T0467 25mL $25 Buy
T0467 100mL $42 Buy
289810 25g $333 Buy

2,4,6-Trimethylaniline Chemical Properties,Uses,Production

Chemical Properties

clear yellow to brown liquid. Insoluble in water, soluble in organic solvents such as ethanol and ether.

Uses

2,4,6-Trimethylaniline is useful for the preparation of Grubbs' catalyst. It is used as a precursor to dyes. It undergoes condensation reaction with glyoxal to prepare glyoxal-bis(mesitylimine). It is also involved in the preparation of 1,3-diketimines ligands by condensation with 1,3-diketones. Further, it is used for the production of Acid Blue 129 dye, which is useful in histochemistry studies. In addition to this, it serves as a building block to various bulky ligands.

Preparation

2,4,6-Trimethylaniline is prepared by selective mononitration of mesitylene, avoiding oxidation of the methyl groups.
Mix sulfuric acid and nitric acid into mixed acid, nitrify with mesitylene at atmospheric pressure below 10°C for 4 hours, stand for stratification, and let off the waste acid. The obtained 2,4,6-trimethylnitrobenzene, iron powder, hydrochloric acid and water were prepared in a ratio of 1:3.74:0.9:2.22 (mol ratio) for reduction reaction at 100-105°C for 8h. Crude 2,4,6-Trimethylaniline was then distilled off from the reduced material and purified by distillation.

Definition

ChEBI: 2,4,6-Trimethylaniline is a substituted aniline.

General Description

2,4,6-Trimethylaniline is a clear liquid. easily turns light brown when exposed to air and light. It is an intermediate for dyes, organic pigments and pesticides.

Reactivity Profile

2,4,6-Trimethylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

2,4,6-Trimethylaniline is moderately toxic orally. It is also considered highly toxic by unspecified routes. It is a skin and eye irritant. Suspect occupational carcinogen. (Non-Specific -- Aromatic Amines) The danger of acute poisoning is represented by methemoglobinemia leading to adverse effects on the red cells. A number of the amines may act as skin sensitizers.

Fire Hazard

When heated to decomposition, 2,4,6-Trimethylaniline emits toxic fumes of nitrogen oxides. Avoid decomposing heat.

Safety Profile

Poison by inhalation. Moderately toxic by ingestion. A skin and severe eye irritant. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

2,4,6-Trimethylaniline (Mesidine) is synthesised from 2-Nitromesitylene through a reduction reaction. The reaction pathway is as follows:
synthesis of 2,4,6-Trimethylaniline

Potential Exposure

Used on small scale in organic synthesis.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

2,4,6-Trimethylaniline synthesis

36016-39-4
108-67-8
88-05-1
Synthesis of 2,4,6-Trimethylaniline from tert-Butyl (Mesitylsulfonyl)oxycarbaMate and Mesitylene

2,4,6-Trimethylaniline Preparation Products And Raw materials

Raw materials

nitrotoluene Mesitylene

Preparation Products

Acid Blue 129 CAFENSTROLE Solvent Blue 104 Tracid Light Yellow G ACID BLUE 80
(E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile 1,4-DICYANONAPHTHALENE 3-Bromo-2,4,6-trimethylaniline 2,4,6-Trimethyliodobenzene 1,3-BIS(2,4,6-TRIMETHYLPHENYL)-IMIDAZOLIDINIUM-CHLORIDE
Acid Violet 48 Acid Blue 129 Solvent Blue 104 Acid Blue 129:1 Acid Violet 126
ACID BLUE 80 Grubbs catalyst 2nd generation

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2,4,6-Trimethylaniline Suppliers

Global( 435)Suppliers
Supplier Tel Email Country ProdList Advantage
changzhou huayang technology co., ltd
+8615250961469 2571773637@qq.com China 9653 58
ANHUI CHICO CHEMICAL CO., LTD.
+8613057662806 kirsten@chicopharm.com China 2620 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5229 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 923 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2950 58
Supplier Advantage
changzhou huayang technology co., ltd
58
ANHUI CHICO CHEMICAL CO., LTD.
58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Jinan Finer Chemical Co., Ltd 		58

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View Lastest Price from 2,4,6-Trimethylaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4,6-Trimethylaniline pictures 2026-05-28 2,4,6-Trimethylaniline
88-05-1
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
2,4,6-Trimethylaniline pictures 2026-04-27 2,4,6-Trimethylaniline
88-05-1
 1kg 98% 100tons Shandong Vital Biotechnology Co., Ltd.
2,4,6-Trimethylaniline pictures 2025-04-15 2,4,6-Trimethylaniline
88-05-1
 $120.00 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd

2,4,6-Trimethylaniline Spectrum

2,4,6-Trimethylaniline(88-05-1)MS2,4,6-Trimethylaniline(88-05-1)1HNMR2,4,6-Trimethylaniline(88-05-1)13CNMR2,4,6-Trimethylaniline(88-05-1)IR12,4,6-Trimethylaniline(88-05-1)IR22,4,6-Trimethylaniline(88-05-1)Raman

88-05-1(2,4,6-Trimethylaniline)Related Search:

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2,4,6-Trimethylanyline 2,4,6-Trimethylaniline,97% 2,4,6-trimethylaniline98% 2,4,6-Trimethylanili 2,4,6-TriMethylaniline, 97% 100GR Aminomesitylene 2-Amino-1,3,5-trimethylbenzene Mesidine Mesitylamine 2,4,6-TRIMETHYLANILINE FOR SYNTHESIS 2 Minus 2-3 Methylaniline 2,4,6-Trimethylaniline (Mesidine), ND25=1,4959 1-amino-2,4,6-trimethylbenzen Mezidine MESIDENE MESITYLAMINE LABOTEST-BB LTBB000742 2,4,6-TRIMETHYLANILINE 2-AMINOMESITYLENE AMINOMESITYLENE AKOS BBS-00003561 2,4,6-Trimethylaniline (mesidine) 2,4,6-TrimethylanilineHCl 1-amino-2,4,6-trimethylbenzen(czech) 1-Amino-2,4,6-trimethylbenzene 2,4,6-trimethyl-anilin 2,4,6-trimethyl-benzenamin 2,4,6-Trimethylphenylamine 2-amino-mesitylen Aniline, 2,4,6-trimethyl- aniline,2,4,6-trimethyl- Benzenamine,2,4,6-trimethyl- Benzeneamine, 2,4,6-trimethyl- Mesidin Mesitylene, 2-amino- 2,4,6-Trimethylaniline > Isotritoluidine Ensifen Group Impurities 55 2,4,6-trimethylbenzenamine 2,4,6-Trimethylanilinehydrochloride 2-AMINO-1,3,5-TRIMETHYLBENZENE MESIDINE 88-05-1 1988-05-1 1988-5-1 1988-05-01 CAS:88-5-1 C9H1N CH32C6H3CH2NH2 CH33C6H2NH2 Organic Building Blocks Nitrogen Compounds Building Blocks Amines C9 to C10 API intermediates Intermediates of Dyes and Pigments bc0001