4-HYDROXYPHTHALIC ANHYDRIDE
- CAS No.
- 27550-59-0
- Chemical Name:
- 4-HYDROXYPHTHALIC ANHYDRIDE
- Synonyms
- 5-hydroxyisobenzofuran-1,3-dione;Hydroxyisobenzofuran4-Hydroxy-phthalicanhydrid;4-HYDROXYPHTHALIC ANHYDRIDE;5-hydroxy-2-benzofuran-1,3-dione;1,3-Isobenzofurandione,5-hydroxy-;5-Hydroxy-1,3-isobenzofurandione, 98+%;5-hydroxy-1,3-dihydro-2-benzofuran-1,3-dione
- CBNumber:
- CB5411627
- Molecular Formula:
- C8H4O4
- Molecular Weight:
- 164.12
- MDL Number:
- MFCD00997252
- MOL File:
- 27550-59-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Hydroxyisobenzofuran-1,3-dione 97% | OR72403 | 1g | $21 |
| 5-Hydroxyisobenzofuran-1,3-dione 97% | OR72403 | 5g | $39 |
| 5-Hydroxyisobenzofuran-1,3-dione 97% | OR72403 | 25g | $184 |
| 5-Hydroxyisobenzofuran-1,3-dione 97% | OR72403 | 100g | $734 |
| 5-Hydroxyisobenzofuran-1,3-dione 97% | OR72403 | 1g | $21 |
| More product size | |||
| Melting point | 171-173 °C(Solv: acetic acid (64-19-7)) |
|---|---|
| Boiling point | 407.8±28.0 °C(Predicted) |
| Density | 1.624±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 6.52±0.20(Predicted) |
| Appearance | Off-white to light brown Solid |
| InChI | InChI=1S/C8H4O4/c9-4-1-2-5-6(3-4)8(11)12-7(5)10/h1-3,9H |
| InChIKey | PXHIYFMTRHEUHZ-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=C(O)C=C2)C(=O)O1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H315-H335 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
4-HYDROXYPHTHALIC ANHYDRIDE price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR72403 | 5-Hydroxyisobenzofuran-1,3-dione 97% | 27550-59-0 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR72403 | 5-Hydroxyisobenzofuran-1,3-dione 97% | 27550-59-0 | 5g | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR72403 | 5-Hydroxyisobenzofuran-1,3-dione 97% | 27550-59-0 | 25g | $184 | 2026-06-04 | Buy |
| Apolloscientific | OR72403 | 5-Hydroxyisobenzofuran-1,3-dione 97% | 27550-59-0 | 100g | $734 | 2026-06-04 | Buy |
| Apolloscientific | OR72403 | 5-Hydroxyisobenzofuran-1,3-dione 97% | 27550-59-0 | 1g | $21 | 2026-06-04 | Buy |
4-HYDROXYPHTHALIC ANHYDRIDE Chemical Properties,Uses,Production
Uses
4-Hydroxyphthalic anhydride is a derivative of 3-hydroxyphthalic anhydride and can be used to modify proteins for in vitro biologics studies.
Synthesis
610-35-5
27550-59-0
The sublimation reaction was carried out at 220 °C and under vacuum conditions (~10 mbar) using 4-hydroxyphthalic acid (1 g, 5.49 mmol) as the raw material. Upon completion of the reaction, the resulting white solid 5-hydroxyisobenzofuran-1,3-dione (675 mg, 4.11 mmol, 74.9% yield, MS/ESI+ 164.9 [MH]+) was collected. The product is to be stored under vacuum and used directly in subsequent reaction steps.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 20, p. 4427 - 4431
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 1, p. 342 - 353
[3] Patent: CN104910113, 2017, B. Location in patent: Page/Page column 0041; 0044-0046
[4] European Journal of Medicinal Chemistry, 1987, vol. 22, p. 229 - 238
[5] Patent: US2013/102576, 2013, A1. Location in patent: Paragraph 0607
4-HYDROXYPHTHALIC ANHYDRIDE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from 4-HYDROXYPHTHALIC ANHYDRIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-20 | 4-HYDROXYPHTHALIC ANHYDRIDE
27550-59-0
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-04 | 4-HYDROXYPHTHALIC ANHYDRIDE
27550-59-0
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
||
 |
2019-07-06 | 4-HYDROXYPHTHALIC ANHYDRIDE
27550-59-0
|
$8.00 | 1kg | 99% | 100MT | Career Henan Chemical Co |
-
- 4-HYDROXYPHTHALIC ANHYDRIDE
27550-59-0
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-HYDROXYPHTHALIC ANHYDRIDE
27550-59-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-HYDROXYPHTHALIC ANHYDRIDE
27550-59-0
- $8.00
- 99%
- Career Henan Chemical Co
