Carbendazim
- CAS No.
- 10605-21-7
- Chemical Name:
- Carbendazim
- Synonyms
- BCM;MBC;CARBENDAZIN;spin;carbendazime;agrizim;BAVISTIN;carbendazole;METHYL 2-BENZIMIDAZOLECARBAMATE;a118
- CBNumber:
- CB5416930
- Molecular Formula:
- C9H9N3O2
- Molecular Weight:
- 191.19
- MDL Number:
- MFCD00055390
- MOL File:
- 10605-21-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| BCMA human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | SRP3010 | 20μG | $394 |
| Fenbendazole Related Compound A certified reference material, pharmaceutical secondary standard | PHR2862 | 50MG | $563 |
| Fenbendazole impurity A European Pharmacopoeia (EP) Reference Standard | F0040010 | 25 mg | $241 |
| Carbendazim 97% | 378674 | 100g | $55 |
| Fenbendazole Related Compound A United States Pharmacopeia (USP) Reference Standard | 1269414 | 30mg | $1340 |
| More product size | |||
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 326.92°C (rough estimate) |
| Density | 1.4500 |
| vapor pressure | 1.5 x 10-4 Pa (25 °C) |
| refractive index | 1.6500 (estimate) |
| Flash point | 11 °C |
| storage temp. | -20°C |
| solubility | pyridine: soluble1%, clear, very faintly brownish-yellow |
| pka | 4.48(at 25℃) |
| form | Solid |
| color | White to off-white |
| biological source | human |
| Water Solubility | <0.1 g/100 mL at 21 ºC |
| Merck | 13,1799 |
| BRN | 649044 |
| Henry's Law Constant | 4.7×105 mol/(m3Pa) at 25℃, HSDB (2015) |
| Major Application |
agriculture cleaning products cosmetics environmental food and beverages personal care |
| InChI | 1S/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13) |
| InChIKey | TWFZGCMQGLPBSX-UHFFFAOYSA-N |
| SMILES | COC(=O)Nc1nc2ccccc2[nH]1 |
| LogP | 1.4-1.5 at 25℃ and pH5-9 |
| CAS DataBase Reference | 10605-21-7(CAS DataBase Reference) |
| EWG's Food Scores | 5 |
| NCI Dictionary of Cancer Terms | carbendazim |
| FDA UNII | H75J14AA89 |
| Pesticides Freedom of Information Act (FOIA) | Carbendazim |
| EPA Substance Registry System | Carbendazim (10605-21-7) |
| UNSPSC Code | 41116107 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H340-H360FD-H410 |
| Precautionary statements | P202-P273-P280-P308+P313-P391-P405 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T,N,F,Xn |
| Risk Statements | 46-60-61-50/53-39/23/24/25-23/24/25-11-52/53 |
| Safety Statements | 53-45-60-61-36/37-16 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | DD6500000 |
| TSCA | TSCA listed |
| HS Code | 29339900 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Muta. 1B Repr. 1B Skin Sens. 1 |
| Hazardous Substances Data | 10605-21-7(Hazardous Substances Data) |
| Toxicity | LD50 oral in rabbit: 8160mg/kg |
| REACH Registrations | Active |
Carbendazim price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP3010 | BCMA human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | 10605-21-7 | 20μG | $394 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2862 | Fenbendazole Related Compound A certified reference material, pharmaceutical secondary standard | 10605-21-7 | 50MG | $563 | 2026-04-30 | Buy |
| Sigma-Aldrich | F0040010 | Fenbendazole impurity A European Pharmacopoeia (EP) Reference Standard | 10605-21-7 | 25 mg | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | 378674 | Carbendazim 97% | 10605-21-7 | 100g | $55 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1269414 | Fenbendazole Related Compound A United States Pharmacopeia (USP) Reference Standard | 10605-21-7 | 30mg | $1340 | 2026-04-30 | Buy |
Carbendazim Chemical Properties,Uses,Production
Description
Carbendazim is the degradation product and active ingredient of the carbamate fungicide benomyl. Carbendazim (100 μM) disrupts the growth of S. cerevisiae by inhibiting microtubule polymerization. It impairs meiosis and steroidogenesis in an ex vivo rat model of seminiferous tubules and increases prostate weight in rats when administered at a dose of 100 mg/kg but does not affect other testosterone-dependent or estrogen-dependent tissues.
Chemical Properties
Colorless crystalline solid or light-gray powder. Commercially supplied as dry concentrate that is mixed with water for spraying.
Uses
Carbendazim is the most widely used active ingredient in the benzimidazole class of fungicides. It is a systemic fungicide with both protective and curative activities against a wide range of fungal diseases, especially caused by most Ascomycetes spp. and some Basidiomycetes and Deuteromycetes spp. in a wide variety of crop and ornamental uses.
Definition
ChEBI: A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomy etes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.
Production Methods
Carbendazim is produced commercially through a multi-step chemical synthesis that builds its benzimidazole core and introduces a carbamate group. O-phenylenediamine is reacted with a carbonyl compound to form the benzimidazole nucleus. The benzimidazole intermediate is then reacted with methyl chloroformate or dimethyl carbonate to introduce the methyl carbamate group at the 2-position.
General Description
Light gray or beige powder.
Air & Water Reactions
Insoluble in water. Carbendazim slowly decomposes in alkaline solution. .
Reactivity Profile
Carbendazim is a carbamate ester-amine. Amines behave as chemical bases. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Carbendazim emits toxic fumes of NOx.
Fire Hazard
Literature sources indicate that Carbendazim is probably nonflammable.
Agricultural Uses
Fungicide: Carbendazim is a systemic fungicide used as a drench to control a broad range of fungi in cereals, vegetables, oilseed rape, sugar beets, grapes, tomatoes, pome fruit and stone fruit. It is also used in post-harvest storage and as treatment in seed pre-planting, frequently in combination with other fungicides. In some areas, it has been used to combat Dutch elm disease.
Trade name
ABACOL®; AIMCOZIM; BAS® 3460; BAS® 67054; BATTAL®; BAVISTIN®; BENDAZIM®; CARBATE®; CARBENDAZIME®; CARBENDAZOL®; CARBENDAZOLE®; CARBENDAZYM®; CARBENDOR; CEKUDAZIM®; CORBEL; CTR® 6669; CUSTOS®; DEFENSOR®; DELSENE®; DEROSAL®; E-965®; DERROPRENE®; EQUITDAZIN®; FUNGISOL®; HOE 17411®; LIGNASAN®; IMISOL®; KEMDAZIN®; MERGAL®; PILLARSTIN®; POLYPHASE®; RODAZIM®; STEMPOR®; SUPERCARB, TRITICOL®; TRITICOL®; U-32.104®
Biochem/physiol Actions
B-cell maturation antigen (BCMA) or tumor necrosis factor receptor superfamily member 17 (TNFRSF17) plays an important role in B cell development, function and regulation. BCMA also has the capability to activate nuclear factor-κB (NF-κB), janus kinase (JNK) and mitogen activated protein kinases (MAPKs). The protein is expressed in certain cancers like glioblastoma, chronic lymphocytic leukemia, Hodgkin lymphoma and multiple myeloma. It has a role in the maintenance of survival of long-lived plasma cells in bone marrow.
Mechanism of action
Systemic with curative and protectant activity. Inhibition of mitosis and cell division (Beta-tubulin assembly in mitosis).
Safety Profile
Moderately toxic by skin contact. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. An agricultural chemical and pesticide. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES.
Potential Exposure
Carbendazim is a benzimidazole/carbamate systemic fungicide used as a drench to control a broad range of fungi in cereals, vegetables, oilseed rape, sugar beets, grapes, tomatoes, pome fruit, and stone fruit. It is also used in postharvest storage and as treatment in seed preplanting, frequently in combination with other fungicides. In some areas, it has been used to combat Dutch Elm disease.
Metabolic pathway
When the mites are exposed to 14C-carbendazim, the major carbendazim metabolite identified in the bulb mites is 5-hydroxy-2-aminobenzimidazole. Low levels of 2-aminobenzimidazole and 5-hydroxy-2- benzimidazole carbamate are also identified.
Shipping
UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required
Degradation
Carbendazim (MBC, 1) was stable in acidic and neutral solutions (pH 5-7,
DT50≥57 days at 22°C), but decomposed rapidly with a DT50 of 22
days (WHO, 1993b) to yield 2-aminobenzimidazole (2, Watluns, 1976;
Zbozinek, 1984) under alkaline conditions (pH 9). An increase in the
salinity of the water accelerated the degradation rate of MBC in water
(Deshpande and Patil, 1987).
Photolysis of MBC in natural sunlight is not a significant dissipation
mechanism in the environment. Significant degradation did not occur
either on leaf surfaces exposed to natural sunlight or in unamended dilute
aqueous solution. Degradation occurred in solution under natural sunlight
if photoinitiators such as riboflavin or acetone were present (Fleeker
and Lacy, 1977).
Incompatibilities
Carbamates are incompatible with reducing agents, strong acids, oxidizing acids, peroxides, and bases. Contact with active metals or nitrides cause the release of flammable, and potentially explosive, hydrogen gas.
Waste Disposal
Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Incineration with effluent gas scrubbing is recommended. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
References
[1] JEAN P. ROUCHAUD. Metabolism of benomyl in carrot, strawberry and apple[J]. Pest Management Science, 1977, 8 1: 23-30. DOI: 10.1002/ps.2780080104
[2] HAN SOL LEE . An effective methodology for simultaneous quantification of thiophanate-methyl, and its metabolite carbendazim in pear, using LC-MS/MS[J]. Journal of Chromatography B, 2018, 1095: Pages 1-7. DOI: 10.1016/j.jchromb.2018.07.010
[3] MIKIO CHIBA Darrell F V. Fate of benomyl and its degradation compound methyl 2-benzimidazolecarbamate on apple foliage[J]. Journal of Agricultural and Food Chemistry, 1981, 29 3: 588-590. DOI: 10.1021/jf00105a038
[4] NICHOLAS T AMPONSAH. Evaluation of fungicides for the management of Botryosphaeria dieback diseases of grapevines[J]. Pest Management Science, 2012, 68 5: 676-683. DOI: 10.1002/ps.2309
[5] R A QUINLAN K G C I Pogson. The influence of the microtubule inhibitor, methyl benzimidazol-2-yl-carbamate (MBC) on nuclear division and the cell cycle in Saccharomyces cerevisiae.[J]. Journal of cell science, 1980, 46: 341-352. DOI: 10.1242/jcs.46.1.341
[6] CéDRIC PISANI. Ex vivo assessment of testicular toxicity induced by carbendazim and iprodione, alone or in a mixture.[J]. Altex-Alternatives To Animal Experimentation, 2016, 33 4: 393-413. DOI: 10.14573/altex.1601253
[7] ELKIANE MACEDO RAMA . Reproductive and possible hormonal effects of carbendazim[J]. Regulatory Toxicology and Pharmacology, 2014, 69 3: Pages 476-486. DOI: 10.1016/j.yrtph.2014.05.016
[8] YASSINE MAKNI . Optimisation and implementation of QuEChERS-based sample preparation for identification and semi-quantification of 694 targeted contaminants in honey, jam, jelly, and syrup by UHPLC-Q/ToF high-resolution mass spectrometry[J]. Food Chemistry, 2023, 425: Article 136448. DOI: 10.1016/j.foodchem.2023.136448
Pesticide Type
Fungicide; Metabolite
Carbendazim Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| .GZ HONESTCHEM CO.,LTD | +86-15013270415 | honestchemical@foxmail.com | China | 273 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3970 | 58 |
| Qingdao Trust Agri Chemical Co.,Ltd | +86-008615963231493 +86-008613573296305 | trustagri@hotmail.com | China | 298 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5216 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2984 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6339 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 |
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View Lastest Price from Carbendazim manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | BMK
27053-08-5
|
$1.00 | 300g | 99.8% | 20 TONS | .GZ HONESTCHEM CO.,LTD | |
 |
2026-08-20 | Carbendazim
10605-21-7
|
$62.00 | 99.82% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-14 | carbendazim
10605-21-7
|
1kg | 99 | 20tons | Qingdao Trust Agri Chemical Co.,Ltd |
-
- BMK
27053-08-5
- $1.00
- 99.8%
- .GZ HONESTCHEM CO.,LTD
-
- Carbendazim
10605-21-7
- $62.00
- 99.82%
- TargetMol Chemicals Inc.
-
- carbendazim
10605-21-7
- $0.00
- 99
- Qingdao Trust Agri Chemical Co.,Ltd
