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5-AMINO-3-METHYL-1,2,4-THIADIAZOLE

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE structure

CAS No.: 17467-35-5

Chemical Name:: 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE

Synonyms: 3-methyl-1,2,4-thiadiazol-5-amine;TIMTEC-BB SBB005481;5-Amino-3-Methyl-1,2,4-thiadizole;5-Amino-3-Methyl-1,3,4-Thiadiazole;5-AMINO-3-METHYL-1,2,4-THIADIAZOLE;3-METHYL-1,2,4-THIADIAZOL-5-YLAMINE;1,2,4-Thiadiazol-5-amine, 3-methyl-;5-Amino-3-methyl-1,2,4-thiadiazole ,99%;5-aMino-3-Methyl-1,2,4-thiadiazole, 98%+

CBNumber:: CB5423134

Molecular Formula:: C3H5N3S

Molecular Weight:: 115.16

MDL Number:: MFCD01114751

MOL File:: 17467-35-5.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:46

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5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Properties

Melting point	202 °C
Boiling point	261.2±23.0 °C(Predicted)
Density	1.372±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	4.56±0.50(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C3H5N3S/c1-2-5-3(4)7-6-2/h1H3,(H2,4,5,6)
InChIKey	DJKUIGPCSNRFRK-UHFFFAOYSA-N
SMILES	S1C(N)=NC(C)=N1
CAS DataBase Reference	17467-35-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes	Xi,Xn
Risk Statements	20/21/22-36/37/38-22
Safety Statements	26-36
HazardClass	IRRITANT
HS Code	2934999090

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B485953	3-Methyl-1,2,4-thiadiazol-5-amine	17467-35-5	100mg	$60	2021-12-16	Buy
Biosynth Carbosynth	FA55393	5-Amino-3-methyl-1,2,4-thiadiazole	17467-35-5	2g	$70.7	2021-12-16	Buy
Matrix Scientific	047478	3-Methyl-1,2,4-thiadiazol-5-amine >95%	17467-35-5	25g	$98	2021-12-16	Buy
SynQuest Laboratories	7H30-1-08	5-Amino-3-methyl-1,2,4-thiadiazole	17467-35-5	1g	$112	2021-12-16	Buy
Biosynth Carbosynth	FA55393	5-Amino-3-methyl-1,2,4-thiadiazole	17467-35-5	5G	$148.8	2021-12-16	Buy

Product number	Packaging	Price	Buy
B485953	100mg	$60	Buy
FA55393	2g	$70.7	Buy
047478	25g	$98	Buy
7H30-1-08	1g	$112	Buy
FA55393	5G	$148.8	Buy

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Chemical Properties,Uses,Production

Chemical Properties

prism

Uses

3-methyl-1,2,4-thiadiazol-5-amine is a useful intermediate used in the preparation of 1,2,4-thiadiazole analogue that functions as a non-peptide inhibitor of beta-secretase.

Synthesis

333-20-0

20846-52-0

17467-35-5

The general procedure for the synthesis of 5-amino-3-methyl-1,2,4-thiadiazole from potassium thiocyanate and chloroacetamidine was as follows: chloroacetamidine (5.1 g, 55 mmol) was dissolved in methanol (250 mL) and the resulting solution was cooled to 0 °C. Subsequently, potassium thiocyanate (5.3 g, 55 mmol) was added to the solution. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure, diluted with ethyl acetate (200 mL) and insoluble solids were removed by filtration under reduced pressure. The filtrate was further concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (silica gel, n-hexane:ethyl acetate = 4:1) to afford finally 5-amino-3-methyl-1,2,4-thiadiazole (2 g, 32% yield). The structure of the product was confirmed by 1H NMR (600 MHz, CD3OD), δ 3.27 (s, 3H).

References

[1] Patent: US2012/264727, 2012, A1. Location in patent: Page/Page column 53
[2] Patent: EP2706062, 2014, A2. Location in patent: Paragraph 0199

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE synthesis

Synthesis of 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE from Potassium thiocyanate and 2-chloroacetimidamide

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Preparation Products And Raw materials

Raw materials

Potassium thiocyanate 2-chloroacetimidamide

Preparation Products

5-bromo-3-methyl-1,2,4-thiadiazole

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Suppliers

Global( 179)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5744	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	9029	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58
Win-Win Chemical CO., Limited	0086-577-64498589	sales@win-winchemical.com	CHINA	998	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	1382	58

Supplier	Advantage
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Win-Win Chemical CO., Limited	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Shanghai Worldyang Chemical Co.,Ltd.	58

View Lastest Price from 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-25	5-AMINO-3-METHYL-1,2,4-THIADIAZOLE 17467-35-5	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-06-17	5-Amino-3-methyl-1,2,4-thiadiazole 17467-35-5	US $2.20-8.80 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2019-07-06	5-AMINO-3-METHYL-1,2,4-THIADIAZOLE 17467-35-5	US $1.00 / kg	1kg	99%	100KG	Career Henan Chemical Co

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE
17467-35-5
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

5-Amino-3-methyl-1,2,4-thiadiazole
17467-35-5
US $2.20-8.80 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE
17467-35-5
US $1.00 / kg
99%
Career Henan Chemical Co

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE Spectrum

5-AMINO-3-METHYL-1,2,4-THIADIAZOLE(17467-35-5)¹HNMR

17467-35-5(5-AMINO-3-METHYL-1,2,4-THIADIAZOLE)Related Search:

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TIMTEC-BB SBB005481 5-Amino-3-Methyl-1,3,4-Thiadiazole 3-METHYL-1,2,4-THIADIAZOL-5-YLAMINE 5-AMINO-3-METHYL-1,2,4-THIADIAZOLE 1,2,4-Thiadiazol-5-amine, 3-methyl- 5-Amino-3-methyl-1,2,4-thiadiazole ,99% 5-aMino-3-Methyl-1,2,4-thiadiazole, 98%+ 3-methyl-1,2,4-thiadiazol-5-amine 5-Amino-3-Methyl-1,2,4-thiadizole 17467-35-5 C3H5N3S Heterocyclic Compounds Thiadiazol Amines