3-Fluoro-4-methylphenylboronic acid
- CAS No.
- 168267-99-0
- Chemical Name:
- 3-Fluoro-4-methylphenylboronic acid
- Synonyms
- AKOS BRN-0218;CHEMBRDG-BB 4003301;3-FLUORO-P-TOLYLBORONIC ACID;3-Fluoro-4-Methylphenylboronic;3-Fluoro-4-methylphenylboronicaci;3-Fluoro-4-methlbenzeneboronicacid;3-Fluoro-4-methbenzene boronic acid;3-FLUORO-4-METHYLPHENYLBORONIC ACID;3-FLUORO-4-METHYLBENZENEBORONIC ACID;B-(3-fluoro-4-Methylphenyl)-Boronicacid
- CBNumber:
- CB5429479
- Molecular Formula:
- C7H8BFO2
- Molecular Weight:
- 153.95
- MDL Number:
- MFCD02683115
- MOL File:
- 168267-99-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Fluoro-4-methylphenylboronic Acid (contains varying amounts of Anhydride) >97.0%(T) | F0712 | 1g | $28 |
| 3-Fluoro-4-methylphenylboronic Acid (contains varying amounts of Anhydride) >97.0%(T) | F0712 | 5g | $81 |
| 3-Fluoro-4-methylphenylboronic acid | F596515 | 100mg | $45 |
| 3-Fluoro-4-methylphenylboronic acid 99.94% | CS-W009262 | 25g | $67 |
| 3-Fluoro-4-methylphenylboronicacid,97-105%(Assaybytitration) 97-105%(Assaybytitration) | 40208 | 1G | $31.45 |
| More product size | |||
| Melting point | 232-237 °C (lit.) |
|---|---|
| Boiling point | 278.7±50.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 7.76±0.10(Predicted) |
| form | Crystalline Powder |
| color | White |
| BRN | 8544594 |
| InChI | 1S/C7H8BFO2/c1-5-2-3-6(8(10)11)4-7(5)9/h2-4,10-11H,1H3 |
| InChIKey | WPVBHUUZDFUIJA-UHFFFAOYSA-N |
| SMILES | Cc1ccc(cc1F)B(O)O |
| CAS DataBase Reference | 168267-99-0(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38-25 | |||||||||
| Safety Statements | 26-36/37/39-45-37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3-Fluoro-4-methylphenylboronic acid price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0712 | 3-Fluoro-4-methylphenylboronic Acid (contains varying amounts of Anhydride) >97.0%(T) | 168267-99-0 | 1g | $28 | 2026-04-30 | Buy |
| TCI Chemical | F0712 | 3-Fluoro-4-methylphenylboronic Acid (contains varying amounts of Anhydride) >97.0%(T) | 168267-99-0 | 5g | $81 | 2026-04-30 | Buy |
| TRC | F596515 | 3-Fluoro-4-methylphenylboronic acid | 168267-99-0 | 100mg | $45 | 2021-12-16 | Buy |
| ChemScene | CS-W009262 | 3-Fluoro-4-methylphenylboronic acid 99.94% | 168267-99-0 | 25g | $67 | 2021-12-16 | Buy |
| Chem-Impex | 40208 | 3-Fluoro-4-methylphenylboronicacid,97-105%(Assaybytitration) 97-105%(Assaybytitration) | 168267-99-0 | 1G | $31.45 | 2021-12-16 | Buy |
3-Fluoro-4-methylphenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
Off-white Cryst
Uses
Reactant for:• ;Regioselective Suzuki coupling1,2
Uses
suzuki reaction
Uses
3-Fluoro-4-methylphenylboronic acid is an inhibitor of bacterial quorum sensing in Vibrio harveyi.
Synthesis
39998-81-7
168267-99-0
General procedure for the synthesis of 3-fluoro-4-methylphenylboronic acid from 2-fluoro-4-iodotoluene: In a 50 mL round-bottomed flask (equipped with a side arm, condenser, and stirring bar) triphenylphosphine (0.131 g, 0.5 mmol, 20 mol%), 2-fluoro-4-iodotoluene (0.585 g, 2.5 mmol), and triethylamine (1.78 mL, 12.5 mmol). The reaction system was degassed by alternating vacuum and argon filling three times. Palladium dichloride (0.023 g, 0.13 mmol, 5 mol%) was added under positive argon atmosphere. After stirring for 15 minutes at room temperature, diisopropylaminoborane (5 mL, 1 M THF solution, 5 mmol) was added and the reaction mixture was again degassed by alternating vacuum and argon filling three times. The reaction mixture was heated to reflux and kept at reflux for 12 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and methanol (6 mL, note: this is an exothermic reaction accompanied by hydrogen release) was slowly added. After stirring for 15 minutes, all solvent was removed by distillation under reduced pressure to give a black solid. The solid was dissolved in 3M sodium hydroxide solution (8 mL) and washed with hexane (3 x 10 mL). The aqueous phase was cooled to 0°C (ice bath) and acidified with concentrated hydrochloric acid to pH ≤ 1, at which point 3-fluoro-4-methylphenylboronic acid precipitated as a white solid. The aqueous phase was extracted with ether (3 x 10 mL), the organic phases were combined, dried with magnesium sulfate and filtered. The solvent was removed by distillation under reduced pressure to give a white solid product.
References
[1] Tetrahedron, 2011, vol. 67, # 3, p. 576 - 583
3-Fluoro-4-methylphenylboronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9080 | 58 |
View Lastest Price from 3-Fluoro-4-methylphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | 3-Fluoro-4-methylphenylboronic acid
168267-99-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | 3-Fluoro-4-methylphenylboronic acid
168267-99-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-02 | 3-Fluoro-4-methylphenylboronic acid
168267-99-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3-Fluoro-4-methylphenylboronic acid
168267-99-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-Fluoro-4-methylphenylboronic acid
168267-99-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-Fluoro-4-methylphenylboronic acid
168267-99-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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