Ammonium thioglycolate
- CAS No.
- 5421-46-5
- Chemical Name:
- Ammonium thioglycolate
- Synonyms
- ATG;Ammoniumthioglykolat;GSA;Perm salt;AMMONIUM MERCAPTOACETATE;Ammonium 2-mercaptoacetate;GSA7;NESP;GPSA;PHP1A
- CBNumber:
- CB5445341
- Molecular Formula:
- C2H4O2S.H3N
- Molecular Weight:
- 109.15
- MDL Number:
- MFCD00137451
- MOL File:
- 5421-46-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ammonium thioglycolate solution ~60% in H2O | 10010 | 1l | $93.2 |
| Ammonium Thioglycolate (ca. 60% in Water) | A2217 | 25g | $17 |
| Ammonium Thioglycolate (ca. 60% in Water) | A2217 | 500g | $32 |
| Ammonium thioglycolate solution 70%inwater | AA003NSX | 25g | $16 |
| Ammonium thioglycolate solution 70%inwater | AA003NSX | 100g | $23 |
| More product size | |||
| Melting point | 139-139.5 °C |
|---|---|
| Boiling point | 115℃[at 101 325 Pa] |
| Density | 1.22 |
| vapor pressure | 0.001Pa at 25℃ |
| storage temp. | 2-8°C, stored under nitrogen |
| form | Solution |
| Specific Gravity | 1.245 (25℃) |
| color | Clear colorless |
| Odor | strong skunk-like odor |
| Viscosity | 9.06mm2/s |
| Water Solubility | Miscible |
| Cosmetics Ingredients Functions |
HAIR WAVING OR STRAIGHTENING REDUCING DEPILATORY |
| Cosmetic Ingredient Review (CIR) | Ammonium thioglycolate (5421-46-5) |
| InChI | InChI=1S/C2H4O2S.H3N/c3-2(4)1-5;/h5H,1H2,(H,3,4);1H3 |
| InChIKey | JYAVWXRMOOCSOD-UHFFFAOYSA-N |
| SMILES | C([O-])(=O)CS.[NH4+] |
| LogP | -2.99 at 20℃ |
| CAS DataBase Reference | 5421-46-5(CAS DataBase Reference) |
| EWG's Food Scores | 2-4 |
| FDA UNII | 6P9E788VZZ |
| EPA Substance Registry System | Acetic acid, 2-mercapto-, ammonium salt (1:1) (5421-46-5) |
| Cosmetics Info | Ammonium Thioglycolate |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H301-H317 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352 | |||||||||
| PPE | Eyeshields, Gloves | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-43 | |||||||||
| Safety Statements | 36/37-45-37-24 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | AI7525000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Met. Corr. 1 Skin Sens. 1 |
|||||||||
| Hazardous Substances Data | 5421-46-5(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 ipr-rat: 165 mg/kg JPETAB 97,349,49 | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Ammonium thioglycolate price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 10010 | Ammonium thioglycolate solution ~60% in H2O | 5421-46-5 | 1l | $93.2 | 2026-04-30 | Buy |
| TCI Chemical | A2217 | Ammonium Thioglycolate (ca. 60% in Water) | 5421-46-5 | 25g | $17 | 2026-04-30 | Buy |
| TCI Chemical | A2217 | Ammonium Thioglycolate (ca. 60% in Water) | 5421-46-5 | 500g | $32 | 2026-04-30 | Buy |
| aablocks | AA003NSX | Ammonium thioglycolate solution 70%inwater | 5421-46-5 | 25g | $16 | 2026-05-28 | Buy |
| aablocks | AA003NSX | Ammonium thioglycolate solution 70%inwater | 5421-46-5 | 100g | $23 | 2026-05-28 | Buy |
Ammonium thioglycolate Chemical Properties,Uses,Production
Description
Ammonium thioglycolate, also known as perm salt, is the chemical compound with the formula HSCH2CO2NH4. Being the salt of a weak acid and weak base, ammonium thioglycolic acid exists in solution as an equilibrium mixture of the salt itself as well as the free carboxylic acid thioglycolic acid (HSCH2CO2H) and ammonia : HSCH2COO- + NH4+ HSCH2COOH + NH3.
Chemical Properties
Clear colorless solution with characteristic odor
Uses
Solutions of various strengths are used for hair waving and for hair removal.
Uses
acts as a reducing agent in permanent-waving formulations for hair treatment and in shrink-resistant treatment of wool.
Uses
Ammonium thioglycolate is contained in permanent waves solutions and causes contact dermatitis in hairdressers.
Definition
ChEBI: Ammonium thioglycolate is an organic ammonium salt having thioglycolate(1-) as the counterion. Also known as perm salt, it has use in perming hair. It has a role as a reducing agent and an allergen. It contains a thioglycolate(1-).
General Description
Colorless to faint pink liquid with a repulsive, skunk-like odor.
Air & Water Reactions
Water soluble.
Reactivity Profile
Ammonium thioglycolate may be sensitive to heat. Ammonium thioglycolate is incompatible with acids.
Health Hazard
Exposure to this compound may cause sensitivity dermatitis of scalp or hands, with edema, erythema, subcutaneous lesions, burning of skin, papular rash and itching. It may also cause hypoglycemia. Other symptoms include central nervous system depression, convulsions and dyspnea.
Fire Hazard
Flash point data for Ammonium thioglycolate are not available. Ammonium thioglycolate is combustible.
Flammability and Explosibility
Not classified
Contact allergens
This substance is contained in “basic” permanent waves solutions and causes contact dermatitis in hairdressers.
Safety Profile
Poison by intravenous and intraperitoneal routes. An allergen; can cause contact dermatitis. Emits hydrogen sulfide. See also SULFIDES. When heated to decomposition it emits very toxic NOx, SOx, and NH3.
The actual chemistry of perms
A solution containing ammonium thioglycolate contains a lot of free ammonia, which swells hair, rendering it permeable. The thioglycolic acid in the perm solution reduces the disulfide cystine bonds in the cortex of the hair. In a sense, the thioglycolate removes crosslinks. After washing, the hair is treated with a mild solution of hydrogen peroxide, which oxidizes the cysteines back to cystine. These new chemical bonds impart the structural rigidity necessary for a successful perm. The rigidification process is akin to the vulcanization of rubber, where commonly polysulfide linkages are used to crosslink the polymer chains. However, not as many disulfide bonds are reformed as there were before the permanent. As a result, the hair is weaker than before the permanent was applied and repeated applications over the same spot may eventually cause strand breakage.
Chemical concepts related to perms
When discussing the chemistry of perms, one should consider two chemical facts. First is the thiol-disulfide equilibrium:
RSH + R'SSR' R'SH + RSSR'
where R and R' are organic substituents such as methyl (-CH3), ethyl (-C2H5), or -CH2COO-.
The thiol-disulfide exchange reaction is accelerated by bases such as ammonia, because the base generates some thiolate anion (RS- ), which attacks the disulfide. Thus the ammonia plays multiple roles (and more, see below) in this application.
The second chemical fact is that polar molecules are less volatile than nonpolar ones. So the glycolate substituent makes the thiol nonvolatile and hence non-odorous. An added advantage is that the glycolate confers some solubility in water. One could almost certainly use HSCH3 and ammonia to give a perm, but there would be serious olfactory consequences.
Ammonium thioglycolate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qingdao Zhongke Huatai Industrail Co., Ltd. | +86-532-86898076 +86-15153292017 | zkhtchem@163.com | China | 25 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5838 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5216 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | 13343047651 | admin@zlchemi.com | China | 3689 | 58 |
| Shandong Deshang Chemical Co., Ltd. | +86-0531-8875-2665 +86-13153039501 | info@deshangchem.com | China | 659 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5898 | 58 |
| Lotusland Life Sciences | +8615821988213 | info@longyupharma.com | China | 2411 | 58 |
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- Nov 6，2024
View Lastest Price from Ammonium thioglycolate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-11 | Ammonium thioglycolate
5421-46-5
|
1kg /Drum | ≥98% | 50 T/Month | Hebei Qujie Technology Co., Ltd. | ||
 |
2026-06-30 | Ammonium thioglycolate
5421-46-5
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | Ammonium thioglycolate
5421-46-5
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Ammonium thioglycolate
5421-46-5
- $0.00
- ≥98%
- Hebei Qujie Technology Co., Ltd.
-
- Ammonium thioglycolate
5421-46-5
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- Ammonium thioglycolate
5421-46-5
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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