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ChemicalBook >> CAS DataBase List >>1,2,4,5-Tetrafluorobenzene

1,2,4,5-Tetrafluorobenzene

1,2,4,5-Tetrafluorobenzene Structure
1,2,4,5-Tetrafluorobenzene structure
CAS No.
327-54-8
Chemical Name:
1,2,4,5-Tetrafluorobenzene
Synonyms
1,2,4,5-TetrafL;p-Tetrafluorobenzene;1,2,4,5-Tetrafluorbenzol;1,2,4,5-Tetrafluorobenzyl;1,2,4,5-TETRAFLUOROBENZENE;2,3,5,6-Tetrafluorobenzene;benzene,1,2,4,5-tetrafluoro-;1,2,4,5-Tetrafluorobenzene,98%;1,2,4,5-Tetrafluorobenzene 99%;1,2,4,5-TETRAFLUOROBENZENE, 99+%
CBNumber:
CB5454897
Molecular Formula:
C6H2F4
Molecular Weight:
150.07
MDL Number:
MFCD00000307
MOL File:
327-54-8.mol
MSDS File:
SDS
Last updated:2026-01-29 09:46:11
Product description Number Pack Size Price
1,2,4,5-Tetrafluorobenzene ≥99% T11657 5g $111
1,2,4,5-Tetrafluorobenzene >99.0%(GC) T1029 5g $18
1,2,4,5-Tetrafluorobenzene >99.0%(GC) T1029 25g $47
1,2,4,5-Tetrafluorobenzene T310995 1g $45
1,2,4,5-TETRAFLUOROBENZENE 95.00% HCH0015502 10G $1054.05
More product size
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1,2,4,5-Tetrafluorobenzene Properties

Melting point 4 °C (lit.)
Boiling point 90 °C (lit.)
Density 1.344 g/mL at 25 °C (lit.)
refractive index n20/D 1.407(lit.)
Flash point 61 °F
storage temp. Sealed in dry,2-8°C
form clear liquid
color Colorless to Almost colorless
Specific Gravity 1.344
Water Solubility Not miscible or difficult to mix in water.
BRN 1909052
InChI InChI=1S/C6H2F4/c7-3-1-4(8)6(10)2-5(3)9/h1-2H
InChIKey SDXUIOOHCIQXRP-UHFFFAOYSA-N
SMILES C1(F)=CC(F)=C(F)C=C1F
CAS DataBase Reference 327-54-8(CAS DataBase Reference)
FDA UNII AB3CL8US2H
NIST Chemistry Reference Benzene, 1,2,4,5-tetrafluoro-(327-54-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H315-H319-H335
Precautionary statements  P210-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  F,Xi
Risk Statements  11-36/37/38
Safety Statements  16-26-36/37/39-37/39-33-7/9
RIDADR  UN 1993 3/PG 2
WGK Germany  3
Hazard Note  Flammable/Irritant
HazardClass  3
PackingGroup  II
HS Code  29039990
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2
STOT SE 3
Limited Quantities 1.0 L (0.3 gallon) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
1 0

1,2,4,5-Tetrafluorobenzene price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T11657 1,2,4,5-Tetrafluorobenzene ≥99% 327-54-8 5g $111 2025-07-31 Buy
TCI Chemical T1029 1,2,4,5-Tetrafluorobenzene >99.0%(GC) 327-54-8 5g $18 2025-07-31 Buy
TCI Chemical T1029 1,2,4,5-Tetrafluorobenzene >99.0%(GC) 327-54-8 25g $47 2025-07-31 Buy
TRC T310995 1,2,4,5-Tetrafluorobenzene 327-54-8 1g $45 2021-12-16 Buy
American Custom Chemicals Corporation HCH0015502 1,2,4,5-TETRAFLUOROBENZENE 95.00% 327-54-8 10G $1054.05 2021-12-16 Buy
Product number Packaging Price Buy
T11657 5g $111 Buy
T1029 5g $18 Buy
T1029 25g $47 Buy
T310995 1g $45 Buy
HCH0015502 10G $1054.05 Buy

1,2,4,5-Tetrafluorobenzene Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

It is employed as intermediate in organic synthesis. It is also used as pharmaceutical intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 29, p. 3042, 1964 DOI: 10.1021/jo01033a061

Synthesis

First, 2,4-dichlorofluorobenzene was used as a raw material and nitrated in the presence of 98% concentrated sulfuric acid at 20-40℃ to introduce a nitro group at a specific position on the benzene ring, generating 2,4-dichloro-5-fluoronitrobenzene. After purification by toluene extraction, solvent recovery under normal pressure, and vacuum distillation (120-130℃/8 mmHg), anhydrous potassium fluoride was used as the fluorinating agent to carry out a nucleophilic aromatic substitution reaction (Halex reaction) in a polar aprotic solvent at a high temperature of 180-200℃. The fraction with a boiling point of 88-92℃ was collected in time by "reaction-distillation". Through the simultaneous substitution of two chlorine atoms and the nitro group by fluorine atoms, 1,2,4,5-tetrafluorobenzene was finally obtained.

1,2,4,5-Tetrafluorobenzene Preparation Products And Raw materials

Raw materials

Fluoroboric acid Hydrochloric acid 1,2,3,5-Tetrafluorobenzene 1,2,3,4-Tetrafluorobenzene Pentafluorobenzene
hexafluorobenzene

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Preparation Products

2,3,5,6-tetrafluoro-4-mercapto-Benzoic acid 1,2,4,5-Benzenetetrathiol 4H,4'H-OCTAFLUOROBIPHENYL 1,4-DIIODOTETRAFLUOROBENZENE 1,3,5-Trifluorobenzene

1,2,4,5-Tetrafluorobenzene Suppliers

Global( 270)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29833 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Richest Group Ltd 		18017061086 oled@richest-group.com CHINA 5600 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 9983 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5742 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8830 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Fluoropharm Co., Ltd. 		60
career henan chemical co 		58
CONIER CHEM AND PHARMA LIMITED 		58
Richest Group Ltd 		58
Fuxin Pharmaceutical 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58

View Lastest Price from 1,2,4,5-Tetrafluorobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,4,5-Tetrafluorobenzene pictures 2025-12-01 1,2,4,5-Tetrafluorobenzene
327-54-8
 US $0.00 / kg 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
1,2,4,5-Tetrafluorobenzene pictures 2025-09-25 1,2,4,5-Tetrafluorobenzene
327-54-8
 US $100.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
1,2,4,5-Tetrafluorobenzene pictures 2025-04-04 1,2,4,5-Tetrafluorobenzene
327-54-8
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

1,2,4,5-Tetrafluorobenzene Spectrum

1,2,4,5-Tetrafluorobenzene(327-54-8)1HNMR1,2,4,5-Tetrafluorobenzene(327-54-8)Raman1,2,4,5-Tetrafluorobenzene(327-54-8)IR1,2,4,5-Tetrafluorobenzene(327-54-8)FT-IR

327-54-8(1,2,4,5-Tetrafluorobenzene)Related Search:

Florfenicol 4-Fluorobenzaldehyde 2,3,4,5,6-PENTAFLUOROSTYRENE 1,4-DIBROMOTETRAFLUOROBENZENE 2,3,5,6-TETRAFLUOROANISOLE
2',3',4',5',6'-PENTAFLUOROACETOPHENONE 2,3,4,5,6-PENTAFLUOROBENZOPHENONE Decafluorobiphenyl DECAFLUOROBENZOPHENONE Bromopentafluorobenzene
tetrafluorobenzene Transfluthrin FENFLURAMINE DIPHENYL(PENTAFLUOROPHENYL)PHOSPHINE hexafluorobenzene
Pentafluorobenzene 2,3,4,5,6-PENTAFLUOROANISOLE 2,3,5,6-TETRAFLUOROTOLUENE

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2,3,5,6-Tetrafluorobenzene benzene,1,2,4,5-tetrafluoro- p-Tetrafluorobenzene 1,2,4,5-TETRAFLUOROBENZENE 1,2,4,5-TETRAFLUOROBENZENE, 99+% 1,2,4,5-Tetrafluorobenzene 99% 1,2,4,5-Tetrafluorbenzol 1,2,4,5-Tetrafluorobenzene,98% 1,2,4,5-Tetrafluorobenzyl 1,2,4,5-tetrafluorobenzene cation 1,2,4,5-TetrafL 1,2,4,5-Tetrafluorobenzene ISO 9001：2015 REACH 327-54-8 Building Blocks Aryl Organic Building Blocks Halogenated Hydrocarbons C6 Aryl Halogenated Hydrocarbons bc0001 C6